The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes

Abstract Background Cornelia de Lange (CdLS), Fragile X (FXS) and Rubinstein–Taybi syndromes (RTS) evidence unique profiles of autistic characteristics. To delineate these profiles further, the development of early social cognitive abilities in children with CdLS, FXS and RTS was compared to that ob...

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Autores principales:	Katherine Ellis, Jo Moss, Chrysi Stefanidou, Chris Oliver, Ian Apperly
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Development Intellectual disability Rare systemic diseases Autism Cornelia de Lange syndrome Fragile X syndrome Medicine R
Acceso en línea:	https://doaj.org/article/7fcc59ffb57f47c88bf32a9f28b07faf
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spelling	oai:doaj.org-article:7fcc59ffb57f47c88bf32a9f28b07faf2021-11-28T12:22:45ZThe development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes10.1186/s13023-021-02117-41750-1172https://doaj.org/article/7fcc59ffb57f47c88bf32a9f28b07faf2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13023-021-02117-4https://doaj.org/toc/1750-1172Abstract Background Cornelia de Lange (CdLS), Fragile X (FXS) and Rubinstein–Taybi syndromes (RTS) evidence unique profiles of autistic characteristics. To delineate these profiles further, the development of early social cognitive abilities in children with CdLS, FXS and RTS was compared to that observed in typically developing (TD) and autistic (AUT) children. Methods Children with CdLS (N = 22), FXS (N = 19) and RTS (N = 18), completed the Early Social Cognition Scale (ESCogS). Extant data from AUT (N = 19) and TD (N = 86) children were used for comparison. Results Similar to AUT children, children with CdLS, FXS and RTS showed an overall delay in passing ESCogS tasks. Children with CdLS showed a similar degree of delay to AUT children and greater delay than children with FXS and RTS. The CdLS, FXS and RTS groups did not pass tasks in the same sequence observed in TD and AUT children. Children with CdLS (p = 0.04), FXS (p = 0.02) and RTS (p = 0.04) performed better on tasks requiring understanding simple intentions in others significantly more than tasks requiring joint attention skills. Conclusions An underlying mechanism other than general cognitive delay may be disrupting early social cognitive development in children with CdLS, FXS and RTS. Factors that may disrupt early social cognitive development within these syndromes are discussed.Katherine EllisJo MossChrysi StefanidouChris OliverIan ApperlyBMCarticleDevelopmentIntellectual disabilityRare systemic diseasesAutismCornelia de Lange syndromeFragile X syndromeMedicineRENOrphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Development Intellectual disability Rare systemic diseases Autism Cornelia de Lange syndrome Fragile X syndrome Medicine R
spellingShingle	Development Intellectual disability Rare systemic diseases Autism Cornelia de Lange syndrome Fragile X syndrome Medicine R Katherine Ellis Jo Moss Chrysi Stefanidou Chris Oliver Ian Apperly The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes
description	Abstract Background Cornelia de Lange (CdLS), Fragile X (FXS) and Rubinstein–Taybi syndromes (RTS) evidence unique profiles of autistic characteristics. To delineate these profiles further, the development of early social cognitive abilities in children with CdLS, FXS and RTS was compared to that observed in typically developing (TD) and autistic (AUT) children. Methods Children with CdLS (N = 22), FXS (N = 19) and RTS (N = 18), completed the Early Social Cognition Scale (ESCogS). Extant data from AUT (N = 19) and TD (N = 86) children were used for comparison. Results Similar to AUT children, children with CdLS, FXS and RTS showed an overall delay in passing ESCogS tasks. Children with CdLS showed a similar degree of delay to AUT children and greater delay than children with FXS and RTS. The CdLS, FXS and RTS groups did not pass tasks in the same sequence observed in TD and AUT children. Children with CdLS (p = 0.04), FXS (p = 0.02) and RTS (p = 0.04) performed better on tasks requiring understanding simple intentions in others significantly more than tasks requiring joint attention skills. Conclusions An underlying mechanism other than general cognitive delay may be disrupting early social cognitive development in children with CdLS, FXS and RTS. Factors that may disrupt early social cognitive development within these syndromes are discussed.
format	article
author	Katherine Ellis Jo Moss Chrysi Stefanidou Chris Oliver Ian Apperly
author_facet	Katherine Ellis Jo Moss Chrysi Stefanidou Chris Oliver Ian Apperly
author_sort	Katherine Ellis
title	The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes
title_short	The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes
title_full	The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes
title_fullStr	The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes
title_full_unstemmed	The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes
title_sort	development of early social cognitive skills in neurogenetic syndromes associated with autism: cornelia de lange, fragile x and rubinstein–taybi syndromes
publisher	BMC
publishDate	2021
url	https://doaj.org/article/7fcc59ffb57f47c88bf32a9f28b07faf
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The development of early social cognitive skills in neurogenetic syndromes associated with autism: Cornelia de Lange, fragile X and Rubinstein–Taybi syndromes

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