Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.

Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bun...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jonathan S Towner, Tara K Sealy, Marina L Khristova, César G Albariño, Sean Conlan, Serena A Reeder, Phenix-Lan Quan, W Ian Lipkin, Robert Downing, Jordan W Tappero, Samuel Okware, Julius Lutwama, Barnabas Bakamutumaho, John Kayiwa, James A Comer, Pierre E Rollin, Thomas G Ksiazek, Stuart T Nichol
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7fcf63c145cd4ba6baad36d61015e9d3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7fcf63c145cd4ba6baad36d61015e9d3
record_format	dspace
spelling	oai:doaj.org-article:7fcf63c145cd4ba6baad36d61015e9d32021-11-25T05:47:27ZNewly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.1553-73661553-737410.1371/journal.ppat.1000212https://doaj.org/article/7fcf63c145cd4ba6baad36d61015e9d32008-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19023410/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Western Uganda. Laboratory investigation of the initial 29 suspect-case blood specimens by classic methods (antigen capture, IgM and IgG ELISA) and a recently developed random-primed pyrosequencing approach quickly identified this to be an Ebola HF outbreak associated with a newly discovered ebolavirus species (Bundibugyo ebolavirus) distantly related to the Côte d'Ivoire ebolavirus found in western Africa. Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines.Jonathan S TownerTara K SealyMarina L KhristovaCésar G AlbariñoSean ConlanSerena A ReederPhenix-Lan QuanW Ian LipkinRobert DowningJordan W TapperoSamuel OkwareJulius LutwamaBarnabas BakamutumahoJohn KayiwaJames A ComerPierre E RollinThomas G KsiazekStuart T NicholPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 11, p e1000212 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Jonathan S Towner Tara K Sealy Marina L Khristova César G Albariño Sean Conlan Serena A Reeder Phenix-Lan Quan W Ian Lipkin Robert Downing Jordan W Tappero Samuel Okware Julius Lutwama Barnabas Bakamutumaho John Kayiwa James A Comer Pierre E Rollin Thomas G Ksiazek Stuart T Nichol Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.
description	Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Western Uganda. Laboratory investigation of the initial 29 suspect-case blood specimens by classic methods (antigen capture, IgM and IgG ELISA) and a recently developed random-primed pyrosequencing approach quickly identified this to be an Ebola HF outbreak associated with a newly discovered ebolavirus species (Bundibugyo ebolavirus) distantly related to the Côte d'Ivoire ebolavirus found in western Africa. Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines.
format	article
author	Jonathan S Towner Tara K Sealy Marina L Khristova César G Albariño Sean Conlan Serena A Reeder Phenix-Lan Quan W Ian Lipkin Robert Downing Jordan W Tappero Samuel Okware Julius Lutwama Barnabas Bakamutumaho John Kayiwa James A Comer Pierre E Rollin Thomas G Ksiazek Stuart T Nichol
author_facet	Jonathan S Towner Tara K Sealy Marina L Khristova César G Albariño Sean Conlan Serena A Reeder Phenix-Lan Quan W Ian Lipkin Robert Downing Jordan W Tappero Samuel Okware Julius Lutwama Barnabas Bakamutumaho John Kayiwa James A Comer Pierre E Rollin Thomas G Ksiazek Stuart T Nichol
author_sort	Jonathan S Towner
title	Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.
title_short	Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.
title_full	Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.
title_fullStr	Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.
title_full_unstemmed	Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.
title_sort	newly discovered ebola virus associated with hemorrhagic fever outbreak in uganda.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/7fcf63c145cd4ba6baad36d61015e9d3
work_keys_str_mv	AT jonathanstowner newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT taraksealy newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT marinalkhristova newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT cesargalbarino newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT seanconlan newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT serenaareeder newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT phenixlanquan newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT wianlipkin newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT robertdowning newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT jordanwtappero newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT samuelokware newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT juliuslutwama newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT barnabasbakamutumaho newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT johnkayiwa newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT jamesacomer newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT pierreerollin newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT thomasgksiazek newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda AT stuarttnichol newlydiscoveredebolavirusassociatedwithhemorrhagicfeveroutbreakinuganda
_version_	1718414465750269952

Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.

Ejemplares similares