Soluble urokinase plasminogen activator receptor in one-year prediction of major adverse cardiac events in patients after first myocardial infarction treated with primary percutaneous coronary intervention

Introduction Soluble urokinase plasminogen activator receptor (suPAR) level reflects the general condition of the organism and was proved to give independent information in risk stratification of patients. The aim of this study was to assess the usefulness of suPAR in the prediction of adverse cardi...

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Autores principales:	Rafał N. Wlazeł, Marta Migała, Marzenna Zielińska, Lucjan Pawlicki, Kinga Rośniak-Bąk, Iwona Szadkowska
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2018
Materias:	prognostic factors cardiovascular risk serum biomarkers biomarkers cardiovascular risk prediction prognostication after acute myocardial infarction Medicine R
Acceso en línea:	https://doaj.org/article/7fcfa377e41c48a99e99c25d85b8ff4c
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spelling	oai:doaj.org-article:7fcfa377e41c48a99e99c25d85b8ff4c2021-12-02T18:39:09ZSoluble urokinase plasminogen activator receptor in one-year prediction of major adverse cardiac events in patients after first myocardial infarction treated with primary percutaneous coronary intervention1734-19221896-915110.5114/aoms.2016.63596https://doaj.org/article/7fcfa377e41c48a99e99c25d85b8ff4c2018-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Soluble-urokinase-plasminogen-activator-receptor-in-one-year-prediction-of-major,64599,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Soluble urokinase plasminogen activator receptor (suPAR) level reflects the general condition of the organism and was proved to give independent information in risk stratification of patients. The aim of this study was to assess the usefulness of suPAR in the prediction of adverse cardiac events in patients with first myocardial infarction (MI) undergoing primary percutaneous coronary intervention. Additionally, the diagnostic power of suPAR was assessed. Material and methods One hundred and thirty-nine of 150 consecutive patients were included in the study. Serum suPAR level (ELISA, Virogates) as well as C-reactive protein (on admission and at discharge) and maximum troponin T (assessed from successive 6-hour periods of blood collection) were measured. In the 1-year follow-up study the following major adverse cardiac events were observed: myocardial infarction, revascularization, stroke and death. Results Multi-variable analysis revealed prognostic usefulness only for suPAR and glomerular filtration rate: p < 0.0001 and p = 0.018; OR = 2.59 and OR = 0.98 respectively, with area under the curve in receiver operating characteristic analysis for both parameters simultaneously 0.89 (p < 0.0001). There was no correlation between suPAR level and the left ventricular dysfunction parameters or the MI type. Conclusions Soluble urokinase plasminogen activator receptor level appears to be an independent useful biomarker for the prediction of major adverse cardiac events early after first myocardial infarction. The biomarker’s level seems to have more prognostic than diagnostic power.Rafał N. WlazełMarta MigałaMarzenna ZielińskaLucjan PawlickiKinga Rośniak-BąkIwona SzadkowskaTermedia Publishing Housearticleprognostic factorscardiovascular riskserum biomarkersbiomarkerscardiovascular risk predictionprognostication after acute myocardial infarctionMedicineRENArchives of Medical Science, Vol 15, Iss 1, Pp 72-77 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	prognostic factors cardiovascular risk serum biomarkers biomarkers cardiovascular risk prediction prognostication after acute myocardial infarction Medicine R
spellingShingle	prognostic factors cardiovascular risk serum biomarkers biomarkers cardiovascular risk prediction prognostication after acute myocardial infarction Medicine R Rafał N. Wlazeł Marta Migała Marzenna Zielińska Lucjan Pawlicki Kinga Rośniak-Bąk Iwona Szadkowska Soluble urokinase plasminogen activator receptor in one-year prediction of major adverse cardiac events in patients after first myocardial infarction treated with primary percutaneous coronary intervention
description	Introduction Soluble urokinase plasminogen activator receptor (suPAR) level reflects the general condition of the organism and was proved to give independent information in risk stratification of patients. The aim of this study was to assess the usefulness of suPAR in the prediction of adverse cardiac events in patients with first myocardial infarction (MI) undergoing primary percutaneous coronary intervention. Additionally, the diagnostic power of suPAR was assessed. Material and methods One hundred and thirty-nine of 150 consecutive patients were included in the study. Serum suPAR level (ELISA, Virogates) as well as C-reactive protein (on admission and at discharge) and maximum troponin T (assessed from successive 6-hour periods of blood collection) were measured. In the 1-year follow-up study the following major adverse cardiac events were observed: myocardial infarction, revascularization, stroke and death. Results Multi-variable analysis revealed prognostic usefulness only for suPAR and glomerular filtration rate: p < 0.0001 and p = 0.018; OR = 2.59 and OR = 0.98 respectively, with area under the curve in receiver operating characteristic analysis for both parameters simultaneously 0.89 (p < 0.0001). There was no correlation between suPAR level and the left ventricular dysfunction parameters or the MI type. Conclusions Soluble urokinase plasminogen activator receptor level appears to be an independent useful biomarker for the prediction of major adverse cardiac events early after first myocardial infarction. The biomarker’s level seems to have more prognostic than diagnostic power.
format	article
author	Rafał N. Wlazeł Marta Migała Marzenna Zielińska Lucjan Pawlicki Kinga Rośniak-Bąk Iwona Szadkowska
author_facet	Rafał N. Wlazeł Marta Migała Marzenna Zielińska Lucjan Pawlicki Kinga Rośniak-Bąk Iwona Szadkowska
author_sort	Rafał N. Wlazeł
title	Soluble urokinase plasminogen activator receptor in one-year prediction of major adverse cardiac events in patients after first myocardial infarction treated with primary percutaneous coronary intervention
title_short	Soluble urokinase plasminogen activator receptor in one-year prediction of major adverse cardiac events in patients after first myocardial infarction treated with primary percutaneous coronary intervention
title_full	Soluble urokinase plasminogen activator receptor in one-year prediction of major adverse cardiac events in patients after first myocardial infarction treated with primary percutaneous coronary intervention
title_fullStr	Soluble urokinase plasminogen activator receptor in one-year prediction of major adverse cardiac events in patients after first myocardial infarction treated with primary percutaneous coronary intervention
title_full_unstemmed	Soluble urokinase plasminogen activator receptor in one-year prediction of major adverse cardiac events in patients after first myocardial infarction treated with primary percutaneous coronary intervention
title_sort	soluble urokinase plasminogen activator receptor in one-year prediction of major adverse cardiac events in patients after first myocardial infarction treated with primary percutaneous coronary intervention
publisher	Termedia Publishing House
publishDate	2018
url	https://doaj.org/article/7fcfa377e41c48a99e99c25d85b8ff4c
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Soluble urokinase plasminogen activator receptor in one-year prediction of major adverse cardiac events in patients after first myocardial infarction treated with primary percutaneous coronary intervention

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