The use of preexposure treatments for HIV prophylaxis

Adrian Majid, Robert R Redfield, Bruce L GilliamInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USAAbstract: Infection with human immunodeficiency virus remains a global concern with a significant number of incident infections still reported worldwide. The use...

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Autores principales:	Majid A, Redfield RR, Gilliam BL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7fd00fe5705e40828f9a16f7d7a1ac5e
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spelling	oai:doaj.org-article:7fd00fe5705e40828f9a16f7d7a1ac5e2021-12-02T06:09:38ZThe use of preexposure treatments for HIV prophylaxis1179-1373https://doaj.org/article/7fd00fe5705e40828f9a16f7d7a1ac5e2012-02-01T00:00:00Zhttp://www.dovepress.com/the-use-of-preexposure-treatments-for-hiv-prophylaxis-a9204https://doaj.org/toc/1179-1373Adrian Majid, Robert R Redfield, Bruce L GilliamInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USAAbstract: Infection with human immunodeficiency virus remains a global concern with a significant number of incident infections still reported worldwide. The use of prophylaxis prior to exposure to the virus to prevent infection has been a growing area of recent research. Results in nonhuman primates and clinical trials in high-risk patient populations using preexposure prophylaxis have shown promising results in terms of efficacy and safety, especially relating to oral preexposure prophylaxis. The potential use of oral antiretroviral agents traditionally used for human immunodeficiency virus treatment as prophylaxis raises interesting considerations, such as the best agents available for such a role, long-term safety in healthy individuals, and the potential development of resistance to these agents should infection occur. From a public health perspective, the cost-effectiveness of implementing this preventive strategy has not been fully defined at this point in time.Keywords: preexposure prophylaxis, human immunodeficiency virus, tenofovir, maravirocMajid ARedfield RRGilliam BLDove Medical PressarticleImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol 2012, Iss default, Pp 17-28 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607
spellingShingle	Immunologic diseases. Allergy RC581-607 Majid A Redfield RR Gilliam BL The use of preexposure treatments for HIV prophylaxis
description	Adrian Majid, Robert R Redfield, Bruce L GilliamInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USAAbstract: Infection with human immunodeficiency virus remains a global concern with a significant number of incident infections still reported worldwide. The use of prophylaxis prior to exposure to the virus to prevent infection has been a growing area of recent research. Results in nonhuman primates and clinical trials in high-risk patient populations using preexposure prophylaxis have shown promising results in terms of efficacy and safety, especially relating to oral preexposure prophylaxis. The potential use of oral antiretroviral agents traditionally used for human immunodeficiency virus treatment as prophylaxis raises interesting considerations, such as the best agents available for such a role, long-term safety in healthy individuals, and the potential development of resistance to these agents should infection occur. From a public health perspective, the cost-effectiveness of implementing this preventive strategy has not been fully defined at this point in time.Keywords: preexposure prophylaxis, human immunodeficiency virus, tenofovir, maraviroc
format	article
author	Majid A Redfield RR Gilliam BL
author_facet	Majid A Redfield RR Gilliam BL
author_sort	Majid A
title	The use of preexposure treatments for HIV prophylaxis
title_short	The use of preexposure treatments for HIV prophylaxis
title_full	The use of preexposure treatments for HIV prophylaxis
title_fullStr	The use of preexposure treatments for HIV prophylaxis
title_full_unstemmed	The use of preexposure treatments for HIV prophylaxis
title_sort	use of preexposure treatments for hiv prophylaxis
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/7fd00fe5705e40828f9a16f7d7a1ac5e
work_keys_str_mv	AT majida theuseofpreexposuretreatmentsforhivprophylaxis AT redfieldrr theuseofpreexposuretreatmentsforhivprophylaxis AT gilliambl theuseofpreexposuretreatmentsforhivprophylaxis AT majida useofpreexposuretreatmentsforhivprophylaxis AT redfieldrr useofpreexposuretreatmentsforhivprophylaxis AT gilliambl useofpreexposuretreatmentsforhivprophylaxis
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The use of preexposure treatments for HIV prophylaxis

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