Ontogeny of the Projections From the Dorsomedial Division of the Anterior Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei

The bed nucleus of the stria terminalis (BNST) is a telencephalic structure well-connected to hypothalamic regions known to control goal-oriented behaviors such as feeding. In particular, we showed that the dorsomedial division of the anterior BNST innervate neurons of the paraventricular (PVH), dor...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marc Lanzillo, Manon Gervais, Sophie Croizier
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	DiI-based tract tracing ontogeny bed nuclei of the stria terminalis PVH DMH ARH Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/7fd034e21778424a84ed9e24206509ce
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7fd034e21778424a84ed9e24206509ce
record_format	dspace
spelling	oai:doaj.org-article:7fd034e21778424a84ed9e24206509ce2021-12-01T18:16:06ZOntogeny of the Projections From the Dorsomedial Division of the Anterior Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei1662-453X10.3389/fnins.2021.748186https://doaj.org/article/7fd034e21778424a84ed9e24206509ce2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.748186/fullhttps://doaj.org/toc/1662-453XThe bed nucleus of the stria terminalis (BNST) is a telencephalic structure well-connected to hypothalamic regions known to control goal-oriented behaviors such as feeding. In particular, we showed that the dorsomedial division of the anterior BNST innervate neurons of the paraventricular (PVH), dorsomedial (DMH), and arcuate (ARH) hypothalamic nuclei as well as the lateral hypothalamic area (LHA). While the anatomy of these projections has been characterized in mice, their ontogeny has not been studied. In this study, we used the DiI-based tract tracing approach to study the development of BNST projections innervating several hypothalamic areas including the PVH, DMH, ARH, and LHA. These results indicate that projections from the dorsomedial division of the anterior BNST to hypothalamic nuclei are immature at birth and substantially reach the PVH, DMH, and the LHA at P10. In the ARH, only sparse fibers are observed at P10, but their density increased markedly between P12 and P14. Collectively, these findings provide new insight into the ontogeny of hypothalamic circuits, and highlight the importance of considering the developmental context as a direct modulator in their proper formation.Marc LanzilloManon GervaisSophie CroizierFrontiers Media S.A.articleDiI-based tract tracingontogenybed nuclei of the stria terminalisPVHDMHARHNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DiI-based tract tracing ontogeny bed nuclei of the stria terminalis PVH DMH ARH Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	DiI-based tract tracing ontogeny bed nuclei of the stria terminalis PVH DMH ARH Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Marc Lanzillo Manon Gervais Sophie Croizier Ontogeny of the Projections From the Dorsomedial Division of the Anterior Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei
description	The bed nucleus of the stria terminalis (BNST) is a telencephalic structure well-connected to hypothalamic regions known to control goal-oriented behaviors such as feeding. In particular, we showed that the dorsomedial division of the anterior BNST innervate neurons of the paraventricular (PVH), dorsomedial (DMH), and arcuate (ARH) hypothalamic nuclei as well as the lateral hypothalamic area (LHA). While the anatomy of these projections has been characterized in mice, their ontogeny has not been studied. In this study, we used the DiI-based tract tracing approach to study the development of BNST projections innervating several hypothalamic areas including the PVH, DMH, ARH, and LHA. These results indicate that projections from the dorsomedial division of the anterior BNST to hypothalamic nuclei are immature at birth and substantially reach the PVH, DMH, and the LHA at P10. In the ARH, only sparse fibers are observed at P10, but their density increased markedly between P12 and P14. Collectively, these findings provide new insight into the ontogeny of hypothalamic circuits, and highlight the importance of considering the developmental context as a direct modulator in their proper formation.
format	article
author	Marc Lanzillo Manon Gervais Sophie Croizier
author_facet	Marc Lanzillo Manon Gervais Sophie Croizier
author_sort	Marc Lanzillo
title	Ontogeny of the Projections From the Dorsomedial Division of the Anterior Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei
title_short	Ontogeny of the Projections From the Dorsomedial Division of the Anterior Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei
title_full	Ontogeny of the Projections From the Dorsomedial Division of the Anterior Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei
title_fullStr	Ontogeny of the Projections From the Dorsomedial Division of the Anterior Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei
title_full_unstemmed	Ontogeny of the Projections From the Dorsomedial Division of the Anterior Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei
title_sort	ontogeny of the projections from the dorsomedial division of the anterior bed nucleus of the stria terminalis to hypothalamic nuclei
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7fd034e21778424a84ed9e24206509ce
work_keys_str_mv	AT marclanzillo ontogenyoftheprojectionsfromthedorsomedialdivisionoftheanteriorbednucleusofthestriaterminalistohypothalamicnuclei AT manongervais ontogenyoftheprojectionsfromthedorsomedialdivisionoftheanteriorbednucleusofthestriaterminalistohypothalamicnuclei AT sophiecroizier ontogenyoftheprojectionsfromthedorsomedialdivisionoftheanteriorbednucleusofthestriaterminalistohypothalamicnuclei
_version_	1718404701889757184

Ontogeny of the Projections From the Dorsomedial Division of the Anterior Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei

Ejemplares similares