Long Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer

Non-coding RNAs (ncRNAs), or RNA molecules that do not code for proteins, are generally categorized as either small or long ncRNA (lncRNA) and are involved in the pathogenesis of several diseases including many cancers. Identification of a large number of ncRNAs could help to elucidate previously un...

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Autores principales:	Kenji Takahashi, Kenzui Taniue, Yusuke Ono, Mikihiro Fujiya, Yusuke Mizukami, Toshikatsu Okumura
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	long non-coding RNA (lncRNA) extracellular vesicles (EVs) pancreatic ductal adenocarcinoma (PDAC) epithelial-mesenchymal transition (EMT) liquid biopsy microRNA (miRNA) Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7fd1327cec76467c828e3da70c75aa6f
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spelling	oai:doaj.org-article:7fd1327cec76467c828e3da70c75aa6f2021-11-08T06:07:55ZLong Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer2296-889X10.3389/fmolb.2021.717890https://doaj.org/article/7fd1327cec76467c828e3da70c75aa6f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.717890/fullhttps://doaj.org/toc/2296-889XNon-coding RNAs (ncRNAs), or RNA molecules that do not code for proteins, are generally categorized as either small or long ncRNA (lncRNA) and are involved in the pathogenesis of several diseases including many cancers. Identification of a large number of ncRNAs could help to elucidate previously unknown mechanisms in phenotype regulation. Some ncRNAs are encapsulated by extracellular vesicles (EVs) and transferred to recipient cells to regulate cellular processes, including epigenetic and post-transcriptional regulations. Recent studies have uncovered novel molecular mechanisms and functions of lncRNAs in pancreatic ductal adenocarcinoma (PDAC), one of the most intractable cancers that is highly invasive and metastatic. As the epithelial-mesenchymal transition (EMT) triggers tumor cell invasion and migration, clarification of the roles of lncRNA in EMT and tumor cell stemness would be critical for improving diagnostic and therapeutic approaches in metastatic cancers. This review provides an overview of relevant studies on lncRNA and its involvement with EMT in PDAC. Emerging knowledge offers evidence for the dysregulated expression of lncRNAs and essential insights into the potential contribution of both lncRNAs and EVs in the pathogenesis of PDAC. Future directions and new clinical applications for PDAC are also discussed.Kenji TakahashiKenzui TaniueKenzui TaniueYusuke OnoMikihiro FujiyaYusuke MizukamiYusuke MizukamiToshikatsu OkumuraFrontiers Media S.A.articlelong non-coding RNA (lncRNA)extracellular vesicles (EVs)pancreatic ductal adenocarcinoma (PDAC)epithelial-mesenchymal transition (EMT)liquid biopsymicroRNA (miRNA)Biology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	long non-coding RNA (lncRNA) extracellular vesicles (EVs) pancreatic ductal adenocarcinoma (PDAC) epithelial-mesenchymal transition (EMT) liquid biopsy microRNA (miRNA) Biology (General) QH301-705.5
spellingShingle	long non-coding RNA (lncRNA) extracellular vesicles (EVs) pancreatic ductal adenocarcinoma (PDAC) epithelial-mesenchymal transition (EMT) liquid biopsy microRNA (miRNA) Biology (General) QH301-705.5 Kenji Takahashi Kenzui Taniue Kenzui Taniue Yusuke Ono Mikihiro Fujiya Yusuke Mizukami Yusuke Mizukami Toshikatsu Okumura Long Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer
description	Non-coding RNAs (ncRNAs), or RNA molecules that do not code for proteins, are generally categorized as either small or long ncRNA (lncRNA) and are involved in the pathogenesis of several diseases including many cancers. Identification of a large number of ncRNAs could help to elucidate previously unknown mechanisms in phenotype regulation. Some ncRNAs are encapsulated by extracellular vesicles (EVs) and transferred to recipient cells to regulate cellular processes, including epigenetic and post-transcriptional regulations. Recent studies have uncovered novel molecular mechanisms and functions of lncRNAs in pancreatic ductal adenocarcinoma (PDAC), one of the most intractable cancers that is highly invasive and metastatic. As the epithelial-mesenchymal transition (EMT) triggers tumor cell invasion and migration, clarification of the roles of lncRNA in EMT and tumor cell stemness would be critical for improving diagnostic and therapeutic approaches in metastatic cancers. This review provides an overview of relevant studies on lncRNA and its involvement with EMT in PDAC. Emerging knowledge offers evidence for the dysregulated expression of lncRNAs and essential insights into the potential contribution of both lncRNAs and EVs in the pathogenesis of PDAC. Future directions and new clinical applications for PDAC are also discussed.
format	article
author	Kenji Takahashi Kenzui Taniue Kenzui Taniue Yusuke Ono Mikihiro Fujiya Yusuke Mizukami Yusuke Mizukami Toshikatsu Okumura
author_facet	Kenji Takahashi Kenzui Taniue Kenzui Taniue Yusuke Ono Mikihiro Fujiya Yusuke Mizukami Yusuke Mizukami Toshikatsu Okumura
author_sort	Kenji Takahashi
title	Long Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer
title_short	Long Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer
title_full	Long Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer
title_fullStr	Long Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer
title_full_unstemmed	Long Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer
title_sort	long non-coding rnas in epithelial-mesenchymal transition of pancreatic cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7fd1327cec76467c828e3da70c75aa6f
work_keys_str_mv	AT kenjitakahashi longnoncodingrnasinepithelialmesenchymaltransitionofpancreaticcancer AT kenzuitaniue longnoncodingrnasinepithelialmesenchymaltransitionofpancreaticcancer AT kenzuitaniue longnoncodingrnasinepithelialmesenchymaltransitionofpancreaticcancer AT yusukeono longnoncodingrnasinepithelialmesenchymaltransitionofpancreaticcancer AT mikihirofujiya longnoncodingrnasinepithelialmesenchymaltransitionofpancreaticcancer AT yusukemizukami longnoncodingrnasinepithelialmesenchymaltransitionofpancreaticcancer AT yusukemizukami longnoncodingrnasinepithelialmesenchymaltransitionofpancreaticcancer AT toshikatsuokumura longnoncodingrnasinepithelialmesenchymaltransitionofpancreaticcancer
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Long Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer

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