Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

Hydralazine is an FDA approved drug for the treatment of hypertension. Here, Dehghan et al. report that hydralazine triggers the cellular oxidative stress response by activating NRF2/SKN-1 signaling and extends C. elegans healthy lifespan, suggesting hydralazine may have potential to treat age-assoc...

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Autores principales: Esmaeil Dehghan, Yiqiang Zhang, Bahar Saremi, Sivaramakrishna Yadavali, Amirmansoor Hakimi, Maryam Dehghani, Mohammad Goodarzi, Xiaoqin Tu, Scott Robertson, Rueyling Lin, Asish Chudhuri, Hamid Mirzaei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/7fd249672058484eb42b4cddbf922c6e
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spelling oai:doaj.org-article:7fd249672058484eb42b4cddbf922c6e2021-12-02T14:40:56ZHydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway10.1038/s41467-017-02394-32041-1723https://doaj.org/article/7fd249672058484eb42b4cddbf922c6e2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02394-3https://doaj.org/toc/2041-1723Hydralazine is an FDA approved drug for the treatment of hypertension. Here, Dehghan et al. report that hydralazine triggers the cellular oxidative stress response by activating NRF2/SKN-1 signaling and extends C. elegans healthy lifespan, suggesting hydralazine may have potential to treat age-associated diseases more broadly.Esmaeil DehghanYiqiang ZhangBahar SaremiSivaramakrishna YadavaliAmirmansoor HakimiMaryam DehghaniMohammad GoodarziXiaoqin TuScott RobertsonRueyling LinAsish ChudhuriHamid MirzaeiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Esmaeil Dehghan
Yiqiang Zhang
Bahar Saremi
Sivaramakrishna Yadavali
Amirmansoor Hakimi
Maryam Dehghani
Mohammad Goodarzi
Xiaoqin Tu
Scott Robertson
Rueyling Lin
Asish Chudhuri
Hamid Mirzaei
Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway
description Hydralazine is an FDA approved drug for the treatment of hypertension. Here, Dehghan et al. report that hydralazine triggers the cellular oxidative stress response by activating NRF2/SKN-1 signaling and extends C. elegans healthy lifespan, suggesting hydralazine may have potential to treat age-associated diseases more broadly.
format article
author Esmaeil Dehghan
Yiqiang Zhang
Bahar Saremi
Sivaramakrishna Yadavali
Amirmansoor Hakimi
Maryam Dehghani
Mohammad Goodarzi
Xiaoqin Tu
Scott Robertson
Rueyling Lin
Asish Chudhuri
Hamid Mirzaei
author_facet Esmaeil Dehghan
Yiqiang Zhang
Bahar Saremi
Sivaramakrishna Yadavali
Amirmansoor Hakimi
Maryam Dehghani
Mohammad Goodarzi
Xiaoqin Tu
Scott Robertson
Rueyling Lin
Asish Chudhuri
Hamid Mirzaei
author_sort Esmaeil Dehghan
title Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway
title_short Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway
title_full Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway
title_fullStr Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway
title_full_unstemmed Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway
title_sort hydralazine induces stress resistance and extends c. elegans lifespan by activating the nrf2/skn-1 signalling pathway
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/7fd249672058484eb42b4cddbf922c6e
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