Recombinant tissue plasminogen activator in the treatment of suprachoroidal hemorrhage

Nancy Kunjukunju1, Christine R Gonzales2, William S Rodden21Ochsner Medical Center, New Orleans, Louisiana; 2Retina and Vitreous Center of Southern Oregon, Ashland, Oregon, USABackground: Suprachoroidal hemorrhages are a vision-threatening complication, and poor visual outcome is correlated with inc...

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Autores principales:	Nancy Kunjukunju, Christine R Gonzales, William S Rodden
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7fd2b113c69b43aaba4c9d89964f8ea3
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spelling	oai:doaj.org-article:7fd2b113c69b43aaba4c9d89964f8ea32021-12-02T03:59:48ZRecombinant tissue plasminogen activator in the treatment of suprachoroidal hemorrhage1177-54671177-5483https://doaj.org/article/7fd2b113c69b43aaba4c9d89964f8ea32011-02-01T00:00:00Zhttp://www.dovepress.com/recombinant-tissue-plasminogen-activator-in-the-treatment-of-suprachor-a6215https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Nancy Kunjukunju1, Christine R Gonzales2, William S Rodden21Ochsner Medical Center, New Orleans, Louisiana; 2Retina and Vitreous Center of Southern Oregon, Ashland, Oregon, USABackground: Suprachoroidal hemorrhages are a vision-threatening complication, and poor visual outcome is correlated with increasing hemorrhage complexity. The recommended time of surgical drainage is 10&ndash;14 days after the hemorrhage begins to liquefy. We describe a case in which recombinant tissue plasminogen activator (r-tPA), alteplase, is injected within the suprachoroidal space before surgery to assist in the drainage of an organized clot prior to liquefaction. This is a report of a technique in which r-tPA is used in the intrachoroidal space to target the organized clot of suprachoroidal hemorrhage prior to drainage.Case report: A 62-year-old male presented 12 days after retinal detachment repair with sudden ocular pain and vision loss after a Valsalva maneuver. Vision was light perception only, and intraocular pressure was 43 mmHg. Diagnosed with hyphema and suprachoroidal hemorrhage, the patient underwent surgery the following day. An injection of r-tPA 100 &micro;g was given intracamerally, and an additional dose of r-tPA 100 &micro;g was injected into the suprachoroidal space prior to surgery. Liquified by r-tPA, the clot was expressed through the sclerotomies. Best corrected vision in the eye eight months after the drainage procedure was 20/40.Conclusion: To the author&rsquo;s knowledge, this is the first reported case in which r-tPA was successfully injected in the suprachoroidal space to liquefy and drain a suprachoroidal hemorrhage prior to natural dissolution.Keywords: tPA, suprachoroidal hemorrhage, vision loss Nancy KunjukunjuChristine R GonzalesWilliam S RoddenDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 155-157 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Nancy Kunjukunju Christine R Gonzales William S Rodden Recombinant tissue plasminogen activator in the treatment of suprachoroidal hemorrhage
description	Nancy Kunjukunju1, Christine R Gonzales2, William S Rodden21Ochsner Medical Center, New Orleans, Louisiana; 2Retina and Vitreous Center of Southern Oregon, Ashland, Oregon, USABackground: Suprachoroidal hemorrhages are a vision-threatening complication, and poor visual outcome is correlated with increasing hemorrhage complexity. The recommended time of surgical drainage is 10&ndash;14 days after the hemorrhage begins to liquefy. We describe a case in which recombinant tissue plasminogen activator (r-tPA), alteplase, is injected within the suprachoroidal space before surgery to assist in the drainage of an organized clot prior to liquefaction. This is a report of a technique in which r-tPA is used in the intrachoroidal space to target the organized clot of suprachoroidal hemorrhage prior to drainage.Case report: A 62-year-old male presented 12 days after retinal detachment repair with sudden ocular pain and vision loss after a Valsalva maneuver. Vision was light perception only, and intraocular pressure was 43 mmHg. Diagnosed with hyphema and suprachoroidal hemorrhage, the patient underwent surgery the following day. An injection of r-tPA 100 &micro;g was given intracamerally, and an additional dose of r-tPA 100 &micro;g was injected into the suprachoroidal space prior to surgery. Liquified by r-tPA, the clot was expressed through the sclerotomies. Best corrected vision in the eye eight months after the drainage procedure was 20/40.Conclusion: To the author&rsquo;s knowledge, this is the first reported case in which r-tPA was successfully injected in the suprachoroidal space to liquefy and drain a suprachoroidal hemorrhage prior to natural dissolution.Keywords: tPA, suprachoroidal hemorrhage, vision loss
format	article
author	Nancy Kunjukunju Christine R Gonzales William S Rodden
author_facet	Nancy Kunjukunju Christine R Gonzales William S Rodden
author_sort	Nancy Kunjukunju
title	Recombinant tissue plasminogen activator in the treatment of suprachoroidal hemorrhage
title_short	Recombinant tissue plasminogen activator in the treatment of suprachoroidal hemorrhage
title_full	Recombinant tissue plasminogen activator in the treatment of suprachoroidal hemorrhage
title_fullStr	Recombinant tissue plasminogen activator in the treatment of suprachoroidal hemorrhage
title_full_unstemmed	Recombinant tissue plasminogen activator in the treatment of suprachoroidal hemorrhage
title_sort	recombinant tissue plasminogen activator in the treatment of suprachoroidal hemorrhage
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/7fd2b113c69b43aaba4c9d89964f8ea3
work_keys_str_mv	AT nancykunjukunju recombinanttissueplasminogenactivatorinthetreatmentofsuprachoroidalhemorrhage AT christinergonzales recombinanttissueplasminogenactivatorinthetreatmentofsuprachoroidalhemorrhage AT williamsrodden recombinanttissueplasminogenactivatorinthetreatmentofsuprachoroidalhemorrhage
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Recombinant tissue plasminogen activator in the treatment of suprachoroidal hemorrhage

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