Fatigue after acquired brain injury impacts health-related quality of life: an exploratory cohort study

Abstract This study aimed to identify the consequences of fatigue, fatigability, cognitive and executive functioning, and emotional state on health-related quality of life (HRQoL) in a clinical group of outpatients after acquired brain injury (ABI). This cross-sectional retrospective study included...

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Autores principales:	Elisabeth Åkerlund, Katharina S. Sunnerhagen, Hanna C. Persson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7fd32cb24e804d5f81978b6a4e8fc5bd
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spelling	oai:doaj.org-article:7fd32cb24e804d5f81978b6a4e8fc5bd2021-11-14T12:18:11ZFatigue after acquired brain injury impacts health-related quality of life: an exploratory cohort study10.1038/s41598-021-01617-42045-2322https://doaj.org/article/7fd32cb24e804d5f81978b6a4e8fc5bd2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01617-4https://doaj.org/toc/2045-2322Abstract This study aimed to identify the consequences of fatigue, fatigability, cognitive and executive functioning, and emotional state on health-related quality of life (HRQoL) in a clinical group of outpatients after acquired brain injury (ABI). This cross-sectional retrospective study included assessing outpatients at a rehabilitation clinic with WAIS-III working memory and coding subtests, and self-rating scales (Fatigue Impact Scale, Dysexecutive Questionnaire, Hospital Anxiety and Depression Scale, and the dimension of health-related quality of life from EQ-5D-3L). The predictive variables were investigated using a binary logistic regression with HRQoL as the dependent variable. Descriptive statistics and correlations were analyzed. Participants reported a lower than average HRQoL (95%), fatigue (90%), and executive dysfunction (75%). Fatigue had a significant impact and explained 20–33% of the variance in HRQoL with a moderate significance on depression (p = 0.579) and executive dysfunction (p = 0.555). Cognitive and executive function and emotional state showed no association with HRQoL. A lower HRQoL, as well as fatigue and cognitive and executive dysfunctions, are common after ABI, with fatigue is a partial explanation of a lower HRQoL.Elisabeth ÅkerlundKatharina S. SunnerhagenHanna C. PerssonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elisabeth Åkerlund Katharina S. Sunnerhagen Hanna C. Persson Fatigue after acquired brain injury impacts health-related quality of life: an exploratory cohort study
description	Abstract This study aimed to identify the consequences of fatigue, fatigability, cognitive and executive functioning, and emotional state on health-related quality of life (HRQoL) in a clinical group of outpatients after acquired brain injury (ABI). This cross-sectional retrospective study included assessing outpatients at a rehabilitation clinic with WAIS-III working memory and coding subtests, and self-rating scales (Fatigue Impact Scale, Dysexecutive Questionnaire, Hospital Anxiety and Depression Scale, and the dimension of health-related quality of life from EQ-5D-3L). The predictive variables were investigated using a binary logistic regression with HRQoL as the dependent variable. Descriptive statistics and correlations were analyzed. Participants reported a lower than average HRQoL (95%), fatigue (90%), and executive dysfunction (75%). Fatigue had a significant impact and explained 20–33% of the variance in HRQoL with a moderate significance on depression (p = 0.579) and executive dysfunction (p = 0.555). Cognitive and executive function and emotional state showed no association with HRQoL. A lower HRQoL, as well as fatigue and cognitive and executive dysfunctions, are common after ABI, with fatigue is a partial explanation of a lower HRQoL.
format	article
author	Elisabeth Åkerlund Katharina S. Sunnerhagen Hanna C. Persson
author_facet	Elisabeth Åkerlund Katharina S. Sunnerhagen Hanna C. Persson
author_sort	Elisabeth Åkerlund
title	Fatigue after acquired brain injury impacts health-related quality of life: an exploratory cohort study
title_short	Fatigue after acquired brain injury impacts health-related quality of life: an exploratory cohort study
title_full	Fatigue after acquired brain injury impacts health-related quality of life: an exploratory cohort study
title_fullStr	Fatigue after acquired brain injury impacts health-related quality of life: an exploratory cohort study
title_full_unstemmed	Fatigue after acquired brain injury impacts health-related quality of life: an exploratory cohort study
title_sort	fatigue after acquired brain injury impacts health-related quality of life: an exploratory cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7fd32cb24e804d5f81978b6a4e8fc5bd
work_keys_str_mv	AT elisabethakerlund fatigueafteracquiredbraininjuryimpactshealthrelatedqualityoflifeanexploratorycohortstudy AT katharinassunnerhagen fatigueafteracquiredbraininjuryimpactshealthrelatedqualityoflifeanexploratorycohortstudy AT hannacpersson fatigueafteracquiredbraininjuryimpactshealthrelatedqualityoflifeanexploratorycohortstudy
_version_	1718429297023123456

Fatigue after acquired brain injury impacts health-related quality of life: an exploratory cohort study

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