Prediction of esophagogastric varices associated with oxaliplatin administration
Abstract Background Oxaliplatin is a key drug for the chemotherapy of colorectal cancer; however, it is also known to cause non‐cirrhotic portal hypertension. We aimed to identify the characteristics of patients who developed esophagogastric varices (EGVs) after treatment with oxaliplatin. Methods T...
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2021
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oai:doaj.org-article:7fd3aed9460141969828ad58921c58222021-11-18T11:25:44ZPrediction of esophagogastric varices associated with oxaliplatin administration2397-907010.1002/jgh3.12668https://doaj.org/article/7fd3aed9460141969828ad58921c58222021-11-01T00:00:00Zhttps://doi.org/10.1002/jgh3.12668https://doaj.org/toc/2397-9070Abstract Background Oxaliplatin is a key drug for the chemotherapy of colorectal cancer; however, it is also known to cause non‐cirrhotic portal hypertension. We aimed to identify the characteristics of patients who developed esophagogastric varices (EGVs) after treatment with oxaliplatin. Methods This study retrospectively analyzed patients with colorectal cancer who were treated with chemotherapy including oxaliplatin between 2010 and 2016. All patients were evaluated by contrast‐enhanced computed tomography (CE‐CT) every 3 months both during and after treatment; and endoscopy was performed when appearance of portal hypertension was suspected. Results A total of 106 patients were divided into two groups: EGV formation (n = 6) and EGV non‐formation (n = 100). In the EGV group, platelet counts decreased and the size of the spleen calculated by CT (CT spleen index; CT‐SI) increased markedly. The highest area under the receiver operating characteristic curve (AUC) for the change in platelet counts was 0.81 (80% sensitivity and 83% specificity) at 3 months post treatment, and the maximum AUC for CT‐SI was 0.89 (79% sensitivity and 83% specificity) at 6 months post treatment. Conclusions EGV formation could be predicted by the assessment of platelet counts and spleen size. If progressive splenomegaly and thrombocytopenia are observed not only during but also after completion of the oxaliplatin‐containing chemotherapy, EGVs should be confirmed by endoscopy for avoiding subsequent rupture.Yosuke SattaRyuta ShigefukuTsunamasa WatanabeTakuro MizukamiTakashi TsudaTatsuya SuzukiTakuya EhiraNobuhiro HattoriHirofumi KiyokawaKazunari NakaharaHiroki IkedaKotaro MatsunagaHideaki TakahashiNobuyuki MatsumotoChiaki OkuseMichihiro SuzukiYu SunakawaHiroshi YasudaFumio ItohWileyarticleesophagogastric varicesoxaliplatinporto‐sinusoidal vascular diseasesplenomegalythrombocytopeniaDiseases of the digestive system. GastroenterologyRC799-869ENJGH Open, Vol 5, Iss 11, Pp 1289-1297 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
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esophagogastric varices oxaliplatin porto‐sinusoidal vascular disease splenomegaly thrombocytopenia Diseases of the digestive system. Gastroenterology RC799-869 |
| spellingShingle |
esophagogastric varices oxaliplatin porto‐sinusoidal vascular disease splenomegaly thrombocytopenia Diseases of the digestive system. Gastroenterology RC799-869 Yosuke Satta Ryuta Shigefuku Tsunamasa Watanabe Takuro Mizukami Takashi Tsuda Tatsuya Suzuki Takuya Ehira Nobuhiro Hattori Hirofumi Kiyokawa Kazunari Nakahara Hiroki Ikeda Kotaro Matsunaga Hideaki Takahashi Nobuyuki Matsumoto Chiaki Okuse Michihiro Suzuki Yu Sunakawa Hiroshi Yasuda Fumio Itoh Prediction of esophagogastric varices associated with oxaliplatin administration |
| description |
Abstract Background Oxaliplatin is a key drug for the chemotherapy of colorectal cancer; however, it is also known to cause non‐cirrhotic portal hypertension. We aimed to identify the characteristics of patients who developed esophagogastric varices (EGVs) after treatment with oxaliplatin. Methods This study retrospectively analyzed patients with colorectal cancer who were treated with chemotherapy including oxaliplatin between 2010 and 2016. All patients were evaluated by contrast‐enhanced computed tomography (CE‐CT) every 3 months both during and after treatment; and endoscopy was performed when appearance of portal hypertension was suspected. Results A total of 106 patients were divided into two groups: EGV formation (n = 6) and EGV non‐formation (n = 100). In the EGV group, platelet counts decreased and the size of the spleen calculated by CT (CT spleen index; CT‐SI) increased markedly. The highest area under the receiver operating characteristic curve (AUC) for the change in platelet counts was 0.81 (80% sensitivity and 83% specificity) at 3 months post treatment, and the maximum AUC for CT‐SI was 0.89 (79% sensitivity and 83% specificity) at 6 months post treatment. Conclusions EGV formation could be predicted by the assessment of platelet counts and spleen size. If progressive splenomegaly and thrombocytopenia are observed not only during but also after completion of the oxaliplatin‐containing chemotherapy, EGVs should be confirmed by endoscopy for avoiding subsequent rupture. |
| format |
article |
| author |
Yosuke Satta Ryuta Shigefuku Tsunamasa Watanabe Takuro Mizukami Takashi Tsuda Tatsuya Suzuki Takuya Ehira Nobuhiro Hattori Hirofumi Kiyokawa Kazunari Nakahara Hiroki Ikeda Kotaro Matsunaga Hideaki Takahashi Nobuyuki Matsumoto Chiaki Okuse Michihiro Suzuki Yu Sunakawa Hiroshi Yasuda Fumio Itoh |
| author_facet |
Yosuke Satta Ryuta Shigefuku Tsunamasa Watanabe Takuro Mizukami Takashi Tsuda Tatsuya Suzuki Takuya Ehira Nobuhiro Hattori Hirofumi Kiyokawa Kazunari Nakahara Hiroki Ikeda Kotaro Matsunaga Hideaki Takahashi Nobuyuki Matsumoto Chiaki Okuse Michihiro Suzuki Yu Sunakawa Hiroshi Yasuda Fumio Itoh |
| author_sort |
Yosuke Satta |
| title |
Prediction of esophagogastric varices associated with oxaliplatin administration |
| title_short |
Prediction of esophagogastric varices associated with oxaliplatin administration |
| title_full |
Prediction of esophagogastric varices associated with oxaliplatin administration |
| title_fullStr |
Prediction of esophagogastric varices associated with oxaliplatin administration |
| title_full_unstemmed |
Prediction of esophagogastric varices associated with oxaliplatin administration |
| title_sort |
prediction of esophagogastric varices associated with oxaliplatin administration |
| publisher |
Wiley |
| publishDate |
2021 |
| url |
https://doaj.org/article/7fd3aed9460141969828ad58921c5822 |
| work_keys_str_mv |
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