Adherence to Antiretroviral Treatment for Prevention of Mother-to-Child Transmission of HIV in Eastern Ethiopia: A Cross-Sectional Study

Anwar Fedlu,1 Birhanu Alie,1 Ammas Siraj Mohammed,2 Fuad Adem,2 Abduselam Hassen1 1School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Department of Clinical Pharmacy, School of Pharmacy, College of Health and Medical Sciences, Haramaya University,...

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Autores principales:	Fedlu A, Alie B, Siraj Mohammed A, Adem F, Hassen A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	pregnant and lactating women medication adherence pmtct harar ethiopia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7fd872b975734e91bb7fef81dde3d818
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spelling	oai:doaj.org-article:7fd872b975734e91bb7fef81dde3d8182021-12-02T15:28:09ZAdherence to Antiretroviral Treatment for Prevention of Mother-to-Child Transmission of HIV in Eastern Ethiopia: A Cross-Sectional Study1179-1373https://doaj.org/article/7fd872b975734e91bb7fef81dde3d8182020-11-01T00:00:00Zhttps://www.dovepress.com/adherence-to-antiretroviral-treatment-for-prevention-of-mother-to-chil-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Anwar Fedlu,1 Birhanu Alie,1 Ammas Siraj Mohammed,2 Fuad Adem,2 Abduselam Hassen1 1School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Department of Clinical Pharmacy, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaCorrespondence: Ammas Siraj MohammedDepartment of Clinical Pharmacy, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaEmail ammassiraj2337@gmail.comIntroduction: Even though PMTCT (prevention of mother-to-child transmission) is the most effective option to prevent vertical transmission of HIV, achieving optimal adherence has been a universal challenge to PMTCT, including Ethiopia.Objective: To assess levels of adherence and associated factors among pregnant and lactating mothers on PMTCT at public health facilities in Harar town, Harari region, Eastern Ethiopia.Methods: A facility-based cross-sectional study was conducted from April 01 to April 30, 2019, at the selected public health facilities of Harar town, Harari regional state, Eastern Ethiopia. Adherence was measured using a multi-method tool that includes pill counting and self-reporting method. Binary logistic regression analysis was used to determine factors associated with PMTCT adherence. The results were adjusted for possible confounding variables and P-value < 0.05 or CI not including 1 was considered statistically significant.Results: Of the 190 included patients, 83.2% of them had good adherence to PMTCT. Forgetfulness (79%) and being busy (71%) were among the main reasons for non-adherence to PMTCT. In multivariate logistic regression, participants who have received counseling on side effects were 3.4 times more likely to have good adherence [AOR=3.4, 95% CI: 2.1– 9.2]; those with previously known HIV status were 2.1 times more likely to have good adherence to PMTCT [AOR=2.1, 95% CI: 1.6– 7.1] and women who were knowledgeable on PMTCT were 5.2 times more likely to have good adherence [AOR=5.2, 95% CI: 1.6– 6.28].Conclusion: In this study, the overall level of adherence to PMTCT care and support was 83.2%. Counseling on side effects, knowledge about PMTCT, and pregnancy status during initiation of ART were the factors that determine adherence of pregnant and lactating women towards PMTCT service. Thus, it is recommended to raise awareness about PMTCT among all reproductive-age women by stressing the benefit of the early initiation of ART and by providing information on the possible side effect of the drugs.Keywords: pregnant and lactating women, medication adherence, PMTCT, Harar, EthiopiaFedlu AAlie BSiraj Mohammed AAdem FHassen ADove Medical Pressarticlepregnant and lactating womenmedication adherencepmtcthararethiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 725-733 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	pregnant and lactating women medication adherence pmtct harar ethiopia Immunologic diseases. Allergy RC581-607
spellingShingle	pregnant and lactating women medication adherence pmtct harar ethiopia Immunologic diseases. Allergy RC581-607 Fedlu A Alie B Siraj Mohammed A Adem F Hassen A Adherence to Antiretroviral Treatment for Prevention of Mother-to-Child Transmission of HIV in Eastern Ethiopia: A Cross-Sectional Study
description	Anwar Fedlu,1 Birhanu Alie,1 Ammas Siraj Mohammed,2 Fuad Adem,2 Abduselam Hassen1 1School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Department of Clinical Pharmacy, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaCorrespondence: Ammas Siraj MohammedDepartment of Clinical Pharmacy, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaEmail ammassiraj2337@gmail.comIntroduction: Even though PMTCT (prevention of mother-to-child transmission) is the most effective option to prevent vertical transmission of HIV, achieving optimal adherence has been a universal challenge to PMTCT, including Ethiopia.Objective: To assess levels of adherence and associated factors among pregnant and lactating mothers on PMTCT at public health facilities in Harar town, Harari region, Eastern Ethiopia.Methods: A facility-based cross-sectional study was conducted from April 01 to April 30, 2019, at the selected public health facilities of Harar town, Harari regional state, Eastern Ethiopia. Adherence was measured using a multi-method tool that includes pill counting and self-reporting method. Binary logistic regression analysis was used to determine factors associated with PMTCT adherence. The results were adjusted for possible confounding variables and P-value < 0.05 or CI not including 1 was considered statistically significant.Results: Of the 190 included patients, 83.2% of them had good adherence to PMTCT. Forgetfulness (79%) and being busy (71%) were among the main reasons for non-adherence to PMTCT. In multivariate logistic regression, participants who have received counseling on side effects were 3.4 times more likely to have good adherence [AOR=3.4, 95% CI: 2.1– 9.2]; those with previously known HIV status were 2.1 times more likely to have good adherence to PMTCT [AOR=2.1, 95% CI: 1.6– 7.1] and women who were knowledgeable on PMTCT were 5.2 times more likely to have good adherence [AOR=5.2, 95% CI: 1.6– 6.28].Conclusion: In this study, the overall level of adherence to PMTCT care and support was 83.2%. Counseling on side effects, knowledge about PMTCT, and pregnancy status during initiation of ART were the factors that determine adherence of pregnant and lactating women towards PMTCT service. Thus, it is recommended to raise awareness about PMTCT among all reproductive-age women by stressing the benefit of the early initiation of ART and by providing information on the possible side effect of the drugs.Keywords: pregnant and lactating women, medication adherence, PMTCT, Harar, Ethiopia
format	article
author	Fedlu A Alie B Siraj Mohammed A Adem F Hassen A
author_facet	Fedlu A Alie B Siraj Mohammed A Adem F Hassen A
author_sort	Fedlu A
title	Adherence to Antiretroviral Treatment for Prevention of Mother-to-Child Transmission of HIV in Eastern Ethiopia: A Cross-Sectional Study
title_short	Adherence to Antiretroviral Treatment for Prevention of Mother-to-Child Transmission of HIV in Eastern Ethiopia: A Cross-Sectional Study
title_full	Adherence to Antiretroviral Treatment for Prevention of Mother-to-Child Transmission of HIV in Eastern Ethiopia: A Cross-Sectional Study
title_fullStr	Adherence to Antiretroviral Treatment for Prevention of Mother-to-Child Transmission of HIV in Eastern Ethiopia: A Cross-Sectional Study
title_full_unstemmed	Adherence to Antiretroviral Treatment for Prevention of Mother-to-Child Transmission of HIV in Eastern Ethiopia: A Cross-Sectional Study
title_sort	adherence to antiretroviral treatment for prevention of mother-to-child transmission of hiv in eastern ethiopia: a cross-sectional study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/7fd872b975734e91bb7fef81dde3d818
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Adherence to Antiretroviral Treatment for Prevention of Mother-to-Child Transmission of HIV in Eastern Ethiopia: A Cross-Sectional Study

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