Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Amiodarone Toxicity

Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans. It has previously been demonstrated that amiodarone and its metabolite (desethylamiodarone, DEA) can inhibit mitochondrial function, particularly complexes I (CI) and II (CII) of the electron transport syst...

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Autores principales: Alina M. Bețiu, Imen Chamkha, Ellen Gustafsson, Elna Meijer, Vlad F. Avram, Eleonor Åsander Frostner, Johannes K. Ehinger, Lucian Petrescu, Danina M. Muntean, Eskil Elmér
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/7fda1e668c234b2e996f3e85b34b882d
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