Effect of tenofovir Administration And Withdrawl On The Kidney Tissues Of Adult Male Albino Rats And The Protective Role Of Vitamin E

Tenofovir disoproxil fumarate is one of antiretroviral drugs used to treat chronic hepatitis B and HIV. In recent studies many Tenofovir problems were recorded; acute kidney injury (AKI), chronic kidney diseases (CKD) and Fanconi syndrome. Vitamin E is a powerful antioxidant that reduce free radi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Rasha M. Abd El-Fattah, Dorreia M. Zaghloul, Eman A. Abd Elrahim, Salwa M. Ouies
Formato: article
Lenguaje:EN
Publicado: South Valley University 2019
Materias:
S
Acceso en línea:https://doaj.org/article/7fdbf059b23e406882bbb59c3d53751a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:7fdbf059b23e406882bbb59c3d53751a
record_format dspace
spelling oai:doaj.org-article:7fdbf059b23e406882bbb59c3d53751a2021-12-02T09:09:48ZEffect of tenofovir Administration And Withdrawl On The Kidney Tissues Of Adult Male Albino Rats And The Protective Role Of Vitamin E10.21608/SVU.2019.13273.10152535-18262535-1877https://doaj.org/article/7fdbf059b23e406882bbb59c3d53751a2019-07-01T00:00:00Zhttps://svu.journals.ekb.eg/article_40731.htmlhttps://doaj.org/toc/2535-1826https://doaj.org/toc/2535-1877Tenofovir disoproxil fumarate is one of antiretroviral drugs used to treat chronic hepatitis B and HIV. In recent studies many Tenofovir problems were recorded; acute kidney injury (AKI), chronic kidney diseases (CKD) and Fanconi syndrome. Vitamin E is a powerful antioxidant that reduce free radical damage. Vitamin E supplementation can protect kidney tissues and enhances their regeneration if it is added to Tenofovir treatment. The aim of the present study is to describe the changes which occur in the kidney tissues of the adult male albino rats after Tenofovir administration and determine whether these changes are reversible or not after drug withdrawal, Also, whether vitamin E has a protective role or not. A total number of 40 adult male albino rats weighting 200-250 grams were used. Rats were divided into four groups, 10 rats in each group. The first group I (control group), The second group II which was treated with Tenofovir 10 mg/kg/day for two months, the third group III which was treated with Tenofovir10 mg/kg/day for two months, vitamin E also was given 100mg/kg/day for two months. The fourth group IV which was treated with Tenofovir 10 mg/kg/day for two months then withdrawal of Tenofovir for one month. There was marked degeneration of renal glomeruli and tubules in group II which was highly statistically significant than control group (P< 0.001), while in group III there was marked improvement of renal glomeruli and tubules which was highly statistically significant than group II (P<0.001). while in group IV these changes were moderately significant when compared with group II (P<0.01). Therefore, Vitamin E has a protective role if it is added to Tenofovir treatment, also vitamin E enhances regeneration of renal tissues after Tenofovir withdrawal.Rasha M. Abd El-FattahDorreia M. ZaghloulEman A. Abd ElrahimSalwa M. OuiesSouth Valley Universityarticletenofovirkidneyfanconi syndromevitamin eAgricultureSVeterinary medicineSF600-1100ENSVU-International Journal of Veterinary Sciences, Vol 2, Iss 2, Pp 71-80 (2019)
institution DOAJ
collection DOAJ
language EN
topic tenofovir
kidney
fanconi syndrome
vitamin e
Agriculture
S
Veterinary medicine
SF600-1100
spellingShingle tenofovir
kidney
fanconi syndrome
vitamin e
Agriculture
S
Veterinary medicine
SF600-1100
Rasha M. Abd El-Fattah
Dorreia M. Zaghloul
Eman A. Abd Elrahim
Salwa M. Ouies
Effect of tenofovir Administration And Withdrawl On The Kidney Tissues Of Adult Male Albino Rats And The Protective Role Of Vitamin E
description Tenofovir disoproxil fumarate is one of antiretroviral drugs used to treat chronic hepatitis B and HIV. In recent studies many Tenofovir problems were recorded; acute kidney injury (AKI), chronic kidney diseases (CKD) and Fanconi syndrome. Vitamin E is a powerful antioxidant that reduce free radical damage. Vitamin E supplementation can protect kidney tissues and enhances their regeneration if it is added to Tenofovir treatment. The aim of the present study is to describe the changes which occur in the kidney tissues of the adult male albino rats after Tenofovir administration and determine whether these changes are reversible or not after drug withdrawal, Also, whether vitamin E has a protective role or not. A total number of 40 adult male albino rats weighting 200-250 grams were used. Rats were divided into four groups, 10 rats in each group. The first group I (control group), The second group II which was treated with Tenofovir 10 mg/kg/day for two months, the third group III which was treated with Tenofovir10 mg/kg/day for two months, vitamin E also was given 100mg/kg/day for two months. The fourth group IV which was treated with Tenofovir 10 mg/kg/day for two months then withdrawal of Tenofovir for one month. There was marked degeneration of renal glomeruli and tubules in group II which was highly statistically significant than control group (P< 0.001), while in group III there was marked improvement of renal glomeruli and tubules which was highly statistically significant than group II (P<0.001). while in group IV these changes were moderately significant when compared with group II (P<0.01). Therefore, Vitamin E has a protective role if it is added to Tenofovir treatment, also vitamin E enhances regeneration of renal tissues after Tenofovir withdrawal.
format article
author Rasha M. Abd El-Fattah
Dorreia M. Zaghloul
Eman A. Abd Elrahim
Salwa M. Ouies
author_facet Rasha M. Abd El-Fattah
Dorreia M. Zaghloul
Eman A. Abd Elrahim
Salwa M. Ouies
author_sort Rasha M. Abd El-Fattah
title Effect of tenofovir Administration And Withdrawl On The Kidney Tissues Of Adult Male Albino Rats And The Protective Role Of Vitamin E
title_short Effect of tenofovir Administration And Withdrawl On The Kidney Tissues Of Adult Male Albino Rats And The Protective Role Of Vitamin E
title_full Effect of tenofovir Administration And Withdrawl On The Kidney Tissues Of Adult Male Albino Rats And The Protective Role Of Vitamin E
title_fullStr Effect of tenofovir Administration And Withdrawl On The Kidney Tissues Of Adult Male Albino Rats And The Protective Role Of Vitamin E
title_full_unstemmed Effect of tenofovir Administration And Withdrawl On The Kidney Tissues Of Adult Male Albino Rats And The Protective Role Of Vitamin E
title_sort effect of tenofovir administration and withdrawl on the kidney tissues of adult male albino rats and the protective role of vitamin e
publisher South Valley University
publishDate 2019
url https://doaj.org/article/7fdbf059b23e406882bbb59c3d53751a
work_keys_str_mv AT rashamabdelfattah effectoftenofoviradministrationandwithdrawlonthekidneytissuesofadultmalealbinoratsandtheprotectiveroleofvitamine
AT dorreiamzaghloul effectoftenofoviradministrationandwithdrawlonthekidneytissuesofadultmalealbinoratsandtheprotectiveroleofvitamine
AT emanaabdelrahim effectoftenofoviradministrationandwithdrawlonthekidneytissuesofadultmalealbinoratsandtheprotectiveroleofvitamine
AT salwamouies effectoftenofoviradministrationandwithdrawlonthekidneytissuesofadultmalealbinoratsandtheprotectiveroleofvitamine
_version_ 1718398193567268864