Disability weight of Clonorchis sinensis infection: captured from community study and model simulation.
<h4>Background</h4>Clonorchiasis is among the most neglected tropical diseases. It is caused by ingesting raw or undercooked fish or shrimp containing the larval of Clonorchis sinensis and mainly endemic in Southeast Asia including China, Korea and Vietnam. The global estimations for pop...
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oai:doaj.org-article:7fde62f42efa48f1bb30eba347cc931e2021-11-18T09:14:39ZDisability weight of Clonorchis sinensis infection: captured from community study and model simulation.1935-27271935-273510.1371/journal.pntd.0001377https://doaj.org/article/7fde62f42efa48f1bb30eba347cc931e2011-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22180791/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Clonorchiasis is among the most neglected tropical diseases. It is caused by ingesting raw or undercooked fish or shrimp containing the larval of Clonorchis sinensis and mainly endemic in Southeast Asia including China, Korea and Vietnam. The global estimations for population at risk and infected are 601 million and 35 million, respectively. However, it is still not listed among the Global Burden of Disease (GBD) and no disability weight is available for it. Disability weight reflects the average degree of loss of life value due to certain chronic disease condition and ranges between 0 (complete health) and 1 (death). It is crucial parameter for calculating the morbidity part of any disease burden in terms of disability-adjusted life years (DALYs).<h4>Methodology/principal findings</h4>According to the probability and disability weight of single sequelae caused by C. sinensis infection, the overall disability weight could be captured through Monte Carlo simulation. The probability of single sequelae was gained from one community investigation, while the corresponding disability weight was searched from the literatures in evidence-based approach. The overall disability weights of the male and female were 0.101 and 0.050, respectively. The overall disability weights of the age group of 5-14, 15-29, 30-44, 45-59 and 60+ were 0.022, 0.052, 0.072, 0.094 and 0.118, respectively. There was some evidence showing that the disability weight and geometric mean of eggs per gram of feces (GMEPG) fitted a logarithmic equation.<h4>Conclusion/significance</h4>The overall disability weights of C. sinensis infection are differential in different sex and age groups. The disability weight captured here may be referred for estimating the disease burden of C. sinensis infection.Men-Bao QianYing-Dan ChenYue-Yi FangLong-Qi XuTing-Jun ZhuTan TanChang-Hai ZhouGuo-Fei WangTie-Wu JiaGuo-Jing YangXiao-Nong ZhouPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 5, Iss 12, p e1377 (2011) |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Men-Bao Qian Ying-Dan Chen Yue-Yi Fang Long-Qi Xu Ting-Jun Zhu Tan Tan Chang-Hai Zhou Guo-Fei Wang Tie-Wu Jia Guo-Jing Yang Xiao-Nong Zhou Disability weight of Clonorchis sinensis infection: captured from community study and model simulation. |
| description |
<h4>Background</h4>Clonorchiasis is among the most neglected tropical diseases. It is caused by ingesting raw or undercooked fish or shrimp containing the larval of Clonorchis sinensis and mainly endemic in Southeast Asia including China, Korea and Vietnam. The global estimations for population at risk and infected are 601 million and 35 million, respectively. However, it is still not listed among the Global Burden of Disease (GBD) and no disability weight is available for it. Disability weight reflects the average degree of loss of life value due to certain chronic disease condition and ranges between 0 (complete health) and 1 (death). It is crucial parameter for calculating the morbidity part of any disease burden in terms of disability-adjusted life years (DALYs).<h4>Methodology/principal findings</h4>According to the probability and disability weight of single sequelae caused by C. sinensis infection, the overall disability weight could be captured through Monte Carlo simulation. The probability of single sequelae was gained from one community investigation, while the corresponding disability weight was searched from the literatures in evidence-based approach. The overall disability weights of the male and female were 0.101 and 0.050, respectively. The overall disability weights of the age group of 5-14, 15-29, 30-44, 45-59 and 60+ were 0.022, 0.052, 0.072, 0.094 and 0.118, respectively. There was some evidence showing that the disability weight and geometric mean of eggs per gram of feces (GMEPG) fitted a logarithmic equation.<h4>Conclusion/significance</h4>The overall disability weights of C. sinensis infection are differential in different sex and age groups. The disability weight captured here may be referred for estimating the disease burden of C. sinensis infection. |
| format |
article |
| author |
Men-Bao Qian Ying-Dan Chen Yue-Yi Fang Long-Qi Xu Ting-Jun Zhu Tan Tan Chang-Hai Zhou Guo-Fei Wang Tie-Wu Jia Guo-Jing Yang Xiao-Nong Zhou |
| author_facet |
Men-Bao Qian Ying-Dan Chen Yue-Yi Fang Long-Qi Xu Ting-Jun Zhu Tan Tan Chang-Hai Zhou Guo-Fei Wang Tie-Wu Jia Guo-Jing Yang Xiao-Nong Zhou |
| author_sort |
Men-Bao Qian |
| title |
Disability weight of Clonorchis sinensis infection: captured from community study and model simulation. |
| title_short |
Disability weight of Clonorchis sinensis infection: captured from community study and model simulation. |
| title_full |
Disability weight of Clonorchis sinensis infection: captured from community study and model simulation. |
| title_fullStr |
Disability weight of Clonorchis sinensis infection: captured from community study and model simulation. |
| title_full_unstemmed |
Disability weight of Clonorchis sinensis infection: captured from community study and model simulation. |
| title_sort |
disability weight of clonorchis sinensis infection: captured from community study and model simulation. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/7fde62f42efa48f1bb30eba347cc931e |
| work_keys_str_mv |
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