Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses

Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses

Yukiko Nagahara,1 Shizuka Koh,1 Kohji Nishida,1 Hitoshi Watanabe1,2 1Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, 2Kansai Rosai Hospital, Amagasaki, Hyogo, Japan Purpose: This study aimed to evaluate the increase in tear meniscus height (TMH) in...

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Autores principales: Nagahara Y, Koh S, Nishida K, Watanabe H
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/7fdef64b1d7b4989adc19b8758d4c6d4
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spelling oai:doaj.org-article:7fdef64b1d7b4989adc19b8758d4c6d42021-12-02T03:59:46ZProlonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses1177-5483https://doaj.org/article/7fdef64b1d7b4989adc19b8758d4c6d42015-06-01T00:00:00Zhttp://www.dovepress.com/prolonged-increase-in-tear-meniscus-height-bynbsp3nbspdiquafosol-ophth-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Yukiko Nagahara,1 Shizuka Koh,1 Kohji Nishida,1 Hitoshi Watanabe1,2 1Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, 2Kansai Rosai Hospital, Amagasaki, Hyogo, Japan Purpose: This study aimed to evaluate the increase in tear meniscus height (TMH) induced by 3% diquafosol ophthalmic solution in eyes with contact lens (CL).Methods: Ten healthy subjects wearing high-water-content CLs received topical instillation of two ophthalmic solutions – 3% diquafosol ophthalmic solution in one eye and artificial tears in the other eye. Lower TMH was measured at 5 minutes, 10 minutes, 15 minutes, 30 minutes, and 60 minutes after instillation by anterior segment optical coherence tomography.Results: TMH increased significantly (P<0.001) at 5 minutes and 15 minutes after instillation of saline compared with the baseline values. After instillation of 3% diquafosol ophthalmic solution, TMH significantly increased (P<0.05) at 5 minutes, 15 minutes, 30 minutes, and 60 minutes compared with the baseline values. Increases in TMH after diquafosol instillation were significantly greater (P<0.05) at 15 minutes, 30 minutes, and 60 minutes than increases in TMH after saline instillation.Conclusion: Topical instillation of 3% diquafosol ophthalmic solution increases TMH for up to 60 minutes in eyes with high-water-content CLs. Keywords: diquafosol ophthalmic solution, tear meniscus height, dry eye, contact lenses, tear filmNagahara YKoh SNishida KWatanabe HDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1029-1031 (2015)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Nagahara Y
Koh S
Nishida K
Watanabe H
Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses
description Yukiko Nagahara,1 Shizuka Koh,1 Kohji Nishida,1 Hitoshi Watanabe1,2 1Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, 2Kansai Rosai Hospital, Amagasaki, Hyogo, Japan Purpose: This study aimed to evaluate the increase in tear meniscus height (TMH) induced by 3% diquafosol ophthalmic solution in eyes with contact lens (CL).Methods: Ten healthy subjects wearing high-water-content CLs received topical instillation of two ophthalmic solutions – 3% diquafosol ophthalmic solution in one eye and artificial tears in the other eye. Lower TMH was measured at 5 minutes, 10 minutes, 15 minutes, 30 minutes, and 60 minutes after instillation by anterior segment optical coherence tomography.Results: TMH increased significantly (P<0.001) at 5 minutes and 15 minutes after instillation of saline compared with the baseline values. After instillation of 3% diquafosol ophthalmic solution, TMH significantly increased (P<0.05) at 5 minutes, 15 minutes, 30 minutes, and 60 minutes compared with the baseline values. Increases in TMH after diquafosol instillation were significantly greater (P<0.05) at 15 minutes, 30 minutes, and 60 minutes than increases in TMH after saline instillation.Conclusion: Topical instillation of 3% diquafosol ophthalmic solution increases TMH for up to 60 minutes in eyes with high-water-content CLs. Keywords: diquafosol ophthalmic solution, tear meniscus height, dry eye, contact lenses, tear film
format article
author Nagahara Y
Koh S
Nishida K
Watanabe H
author_facet Nagahara Y
Koh S
Nishida K
Watanabe H
author_sort Nagahara Y
title Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses
title_short Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses
title_full Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses
title_fullStr Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses
title_full_unstemmed Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses
title_sort prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/7fdef64b1d7b4989adc19b8758d4c6d4
work_keys_str_mv AT nagaharay prolongedincreaseintearmeniscusheightbynbsp3nbspdiquafosolophthalmicsolutionineyeswithnbspcontactlenses
AT kohs prolongedincreaseintearmeniscusheightbynbsp3nbspdiquafosolophthalmicsolutionineyeswithnbspcontactlenses
AT nishidak prolongedincreaseintearmeniscusheightbynbsp3nbspdiquafosolophthalmicsolutionineyeswithnbspcontactlenses
AT watanabeh prolongedincreaseintearmeniscusheightbynbsp3nbspdiquafosolophthalmicsolutionineyeswithnbspcontactlenses
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