Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning

It is challenging to extract structural information from EM density maps at intermediate or low resolutions. Here, the authors present Emap2sec+, a program for detecting nucleotides and protein secondary structures in EM density maps at 5 to 10 Å resolution.

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Autores principales:	Xiao Wang, Eman Alnabati, Tunde W. Aderinwale, Sai Raghavendra Maddhuri Venkata Subramaniya, Genki Terashi, Daisuke Kihara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7fdf26b480c34d9188c773c5752a3afa
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spelling	oai:doaj.org-article:7fdf26b480c34d9188c773c5752a3afa2021-12-02T18:02:56ZDetecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning10.1038/s41467-021-22577-32041-1723https://doaj.org/article/7fdf26b480c34d9188c773c5752a3afa2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22577-3https://doaj.org/toc/2041-1723It is challenging to extract structural information from EM density maps at intermediate or low resolutions. Here, the authors present Emap2sec+, a program for detecting nucleotides and protein secondary structures in EM density maps at 5 to 10 Å resolution.Xiao WangEman AlnabatiTunde W. AderinwaleSai Raghavendra Maddhuri Venkata SubramaniyaGenki TerashiDaisuke KiharaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiao Wang Eman Alnabati Tunde W. Aderinwale Sai Raghavendra Maddhuri Venkata Subramaniya Genki Terashi Daisuke Kihara Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning
description	It is challenging to extract structural information from EM density maps at intermediate or low resolutions. Here, the authors present Emap2sec+, a program for detecting nucleotides and protein secondary structures in EM density maps at 5 to 10 Å resolution.
format	article
author	Xiao Wang Eman Alnabati Tunde W. Aderinwale Sai Raghavendra Maddhuri Venkata Subramaniya Genki Terashi Daisuke Kihara
author_facet	Xiao Wang Eman Alnabati Tunde W. Aderinwale Sai Raghavendra Maddhuri Venkata Subramaniya Genki Terashi Daisuke Kihara
author_sort	Xiao Wang
title	Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning
title_short	Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning
title_full	Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning
title_fullStr	Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning
title_full_unstemmed	Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning
title_sort	detecting protein and dna/rna structures in cryo-em maps of intermediate resolution using deep learning
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7fdf26b480c34d9188c773c5752a3afa
work_keys_str_mv	AT xiaowang detectingproteinanddnarnastructuresincryoemmapsofintermediateresolutionusingdeeplearning AT emanalnabati detectingproteinanddnarnastructuresincryoemmapsofintermediateresolutionusingdeeplearning AT tundewaderinwale detectingproteinanddnarnastructuresincryoemmapsofintermediateresolutionusingdeeplearning AT sairaghavendramaddhurivenkatasubramaniya detectingproteinanddnarnastructuresincryoemmapsofintermediateresolutionusingdeeplearning AT genkiterashi detectingproteinanddnarnastructuresincryoemmapsofintermediateresolutionusingdeeplearning AT daisukekihara detectingproteinanddnarnastructuresincryoemmapsofintermediateresolutionusingdeeplearning
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Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning

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