Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

SREBP transcription factors activate lipid synthesis and generate raw materials to lipidate various proteins. Here, the authors show that a stiff cellular environment causes RhoA lipidation and acto-myosin contraction, which inhibits SREBP1 and connects the extracellular matrix to lipid metabolism.

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Detalles Bibliográficos
Autores principales:	Rebecca Bertolio, Francesco Napoletano, Miguel Mano, Sebastian Maurer-Stroh, Marco Fantuz, Alessandro Zannini, Silvio Bicciato, Giovanni Sorrentino, Giannino Del Sal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7fe5dfbc24b447fdbd0f7459337489fa
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spelling	oai:doaj.org-article:7fe5dfbc24b447fdbd0f7459337489fa2021-12-02T14:40:01ZSterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism10.1038/s41467-019-09152-72041-1723https://doaj.org/article/7fe5dfbc24b447fdbd0f7459337489fa2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09152-7https://doaj.org/toc/2041-1723SREBP transcription factors activate lipid synthesis and generate raw materials to lipidate various proteins. Here, the authors show that a stiff cellular environment causes RhoA lipidation and acto-myosin contraction, which inhibits SREBP1 and connects the extracellular matrix to lipid metabolism.Rebecca BertolioFrancesco NapoletanoMiguel ManoSebastian Maurer-StrohMarco FantuzAlessandro ZanniniSilvio BicciatoGiovanni SorrentinoGiannino Del SalNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca Bertolio Francesco Napoletano Miguel Mano Sebastian Maurer-Stroh Marco Fantuz Alessandro Zannini Silvio Bicciato Giovanni Sorrentino Giannino Del Sal Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
description	SREBP transcription factors activate lipid synthesis and generate raw materials to lipidate various proteins. Here, the authors show that a stiff cellular environment causes RhoA lipidation and acto-myosin contraction, which inhibits SREBP1 and connects the extracellular matrix to lipid metabolism.
format	article
author	Rebecca Bertolio Francesco Napoletano Miguel Mano Sebastian Maurer-Stroh Marco Fantuz Alessandro Zannini Silvio Bicciato Giovanni Sorrentino Giannino Del Sal
author_facet	Rebecca Bertolio Francesco Napoletano Miguel Mano Sebastian Maurer-Stroh Marco Fantuz Alessandro Zannini Silvio Bicciato Giovanni Sorrentino Giannino Del Sal
author_sort	Rebecca Bertolio
title	Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
title_short	Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
title_full	Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
title_fullStr	Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
title_full_unstemmed	Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
title_sort	sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7fe5dfbc24b447fdbd0f7459337489fa
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Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

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