Choroidal thickness and choriocapillaris vascular density in myopic anisometropia

Abstract Background This study aims to examine interocular differences in the choroidal thickness and vascular density of the choriocapillaris in anisometropic myopes and to further explore the relationship between choroidal blood flow and myopia. Methods The sample comprised 44 participants with an...

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Autores principales:	Xinting Liu, Zhiyi Lin, Feifu Wang, Xiaoyi Peng, Wenwen He, Dan Chen, Meixiao Shen, Fan Lu, Jun Jiang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Myopic anisometropia Choroidal choriocapillaris Choroidal thickness Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7febdfbc500142b287764c0727c7af0c
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spelling	oai:doaj.org-article:7febdfbc500142b287764c0727c7af0c2021-12-05T12:16:35ZChoroidal thickness and choriocapillaris vascular density in myopic anisometropia10.1186/s40662-021-00269-92326-0254https://doaj.org/article/7febdfbc500142b287764c0727c7af0c2021-12-01T00:00:00Zhttps://doi.org/10.1186/s40662-021-00269-9https://doaj.org/toc/2326-0254Abstract Background This study aims to examine interocular differences in the choroidal thickness and vascular density of the choriocapillaris in anisometropic myopes and to further explore the relationship between choroidal blood flow and myopia. Methods The sample comprised 44 participants with anisometropic myopia, aged 9 to 18 years, with normal best-corrected visual acuity. All participants underwent a series of examinations, including spherical equivalent refraction (SER) and axial length (AL), measured by a Lenstar optical biometer and optical coherence tomography angiography (OCTA) scanner. OCT measured the choroidal thickness, vascular density, and flow voids of the choriocapillaris, and a customized algorithm was implemented in MATLAB R2017a with the post-correction of AL. The choroidal thickness was measured at the fovea and 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 mm nasally, temporally, inferiorly, and superiorly to the fovea. The vascular density and the flow voids of the choriocapillaris were measured at a 0.6-mm-diameter central circle, and the 0.6–2.5 mm diameter circle in the nasal, temporal, inferior, and superior regions. Repeated-measured ANOVAs were used to analyze the interocular differences. Partial correlations with the K value and age adjustments were used to study the relationships between the choroidal thickness, the choriocapillaris vascular density and flow voids, the SER and AL. Results The choroidal thickness of the more myopic eyes was significantly thinner than less myopic eyes (P ≤ 0.001), and the flow voids in the more myopic eyes were more than less myopic eyes (P = 0.002). There was no significant difference in the vascular density of the choriocapillaris between the more and less myopic eyes (P = 0.525). However, when anisometropia was more than 1.50 D, the vascular density of choriocapillaris in the more myopic eyes was significantly less than the less myopic eyes (P = 0.026). The interocular difference of the choroidal thickness was significantly correlated with the interocular difference in SER and AL in the center, superior, and inferior regions but not in the nasal or temporal regions. The interocular differences of the vascular density and the flow voids of the choriocapillaris were not correlated with the interocular difference of SER and AL. Conclusions The choroidal thickness is thinner in the more myopic eyes. The flow void is increased, and the vascular density of the choriocapillaris is reduced in the more myopic eyes of children with anisometropia exceeding 1.50 D.Xinting LiuZhiyi LinFeifu WangXiaoyi PengWenwen HeDan ChenMeixiao ShenFan LuJun JiangBMCarticleMyopic anisometropiaChoroidal choriocapillarisChoroidal thicknessOphthalmologyRE1-994ENEye and Vision, Vol 8, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Myopic anisometropia Choroidal choriocapillaris Choroidal thickness Ophthalmology RE1-994
spellingShingle	Myopic anisometropia Choroidal choriocapillaris Choroidal thickness Ophthalmology RE1-994 Xinting Liu Zhiyi Lin Feifu Wang Xiaoyi Peng Wenwen He Dan Chen Meixiao Shen Fan Lu Jun Jiang Choroidal thickness and choriocapillaris vascular density in myopic anisometropia
description	Abstract Background This study aims to examine interocular differences in the choroidal thickness and vascular density of the choriocapillaris in anisometropic myopes and to further explore the relationship between choroidal blood flow and myopia. Methods The sample comprised 44 participants with anisometropic myopia, aged 9 to 18 years, with normal best-corrected visual acuity. All participants underwent a series of examinations, including spherical equivalent refraction (SER) and axial length (AL), measured by a Lenstar optical biometer and optical coherence tomography angiography (OCTA) scanner. OCT measured the choroidal thickness, vascular density, and flow voids of the choriocapillaris, and a customized algorithm was implemented in MATLAB R2017a with the post-correction of AL. The choroidal thickness was measured at the fovea and 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 mm nasally, temporally, inferiorly, and superiorly to the fovea. The vascular density and the flow voids of the choriocapillaris were measured at a 0.6-mm-diameter central circle, and the 0.6–2.5 mm diameter circle in the nasal, temporal, inferior, and superior regions. Repeated-measured ANOVAs were used to analyze the interocular differences. Partial correlations with the K value and age adjustments were used to study the relationships between the choroidal thickness, the choriocapillaris vascular density and flow voids, the SER and AL. Results The choroidal thickness of the more myopic eyes was significantly thinner than less myopic eyes (P ≤ 0.001), and the flow voids in the more myopic eyes were more than less myopic eyes (P = 0.002). There was no significant difference in the vascular density of the choriocapillaris between the more and less myopic eyes (P = 0.525). However, when anisometropia was more than 1.50 D, the vascular density of choriocapillaris in the more myopic eyes was significantly less than the less myopic eyes (P = 0.026). The interocular difference of the choroidal thickness was significantly correlated with the interocular difference in SER and AL in the center, superior, and inferior regions but not in the nasal or temporal regions. The interocular differences of the vascular density and the flow voids of the choriocapillaris were not correlated with the interocular difference of SER and AL. Conclusions The choroidal thickness is thinner in the more myopic eyes. The flow void is increased, and the vascular density of the choriocapillaris is reduced in the more myopic eyes of children with anisometropia exceeding 1.50 D.
format	article
author	Xinting Liu Zhiyi Lin Feifu Wang Xiaoyi Peng Wenwen He Dan Chen Meixiao Shen Fan Lu Jun Jiang
author_facet	Xinting Liu Zhiyi Lin Feifu Wang Xiaoyi Peng Wenwen He Dan Chen Meixiao Shen Fan Lu Jun Jiang
author_sort	Xinting Liu
title	Choroidal thickness and choriocapillaris vascular density in myopic anisometropia
title_short	Choroidal thickness and choriocapillaris vascular density in myopic anisometropia
title_full	Choroidal thickness and choriocapillaris vascular density in myopic anisometropia
title_fullStr	Choroidal thickness and choriocapillaris vascular density in myopic anisometropia
title_full_unstemmed	Choroidal thickness and choriocapillaris vascular density in myopic anisometropia
title_sort	choroidal thickness and choriocapillaris vascular density in myopic anisometropia
publisher	BMC
publishDate	2021
url	https://doaj.org/article/7febdfbc500142b287764c0727c7af0c
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Choroidal thickness and choriocapillaris vascular density in myopic anisometropia

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