The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma

Abstract Anaplastic large-cell lymphoma (ALCL) is a rare type of highly malignant, non-Hodgkin lymphoma (NHL). Currently, only studies on the chimeric oncogene NPM-ALK have reported a link to ALCL progression. However, the specific molecular mechanisms underlying the invasion of ALCL are still uncle...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	I-Hsiao Chung, Pei-Hsuan Lu, Yang-Hsiang Lin, Ming-Ming Tsai, Yun-Wen Lin, Chau-Ting Yeh, Kwang-Huei Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7feebdb2f2dd4812a1e17b38d6d1fef3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7feebdb2f2dd4812a1e17b38d6d1fef3
record_format	dspace
spelling	oai:doaj.org-article:7feebdb2f2dd4812a1e17b38d6d1fef32021-12-02T15:06:21ZThe long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma10.1038/s41598-017-00382-72045-2322https://doaj.org/article/7feebdb2f2dd4812a1e17b38d6d1fef32017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00382-7https://doaj.org/toc/2045-2322Abstract Anaplastic large-cell lymphoma (ALCL) is a rare type of highly malignant, non-Hodgkin lymphoma (NHL). Currently, only studies on the chimeric oncogene NPM-ALK have reported a link to ALCL progression. However, the specific molecular mechanisms underlying the invasion of ALCL are still unclear. Here, we sought to investigate differentially expressed, long non-coding RNAs (lncRNAs) in ALCL and their potential biological function. Our microarray analyses revealed that LINC01013, a novel non-coding RNA gene, was highly expressed in clinical specimens of ALCL and was significantly upregulated in invasive ALCL cell lines. Knockdown of LINC01013 suppressed tumor cell invasion; conversely, its overexpression enhanced tumor cell invasion. LINC01013-induced invasion was mediated by activation of the epithelial-to-mesenchymal transition (EMT)-associated proteins, snail and fibronectin. Specifically, LINC01013 induced snail, resulting in activation of fibronectin and enhanced ALCL cell invasion. Collectively, these findings support a potential role for LINC01013 in cancer cell invasion through the snail-fibronectin activation cascade and suggest that LINC01013 could potentially be utilized as a metastasis marker in ALCL.I-Hsiao ChungPei-Hsuan LuYang-Hsiang LinMing-Ming TsaiYun-Wen LinChau-Ting YehKwang-Huei LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q I-Hsiao Chung Pei-Hsuan Lu Yang-Hsiang Lin Ming-Ming Tsai Yun-Wen Lin Chau-Ting Yeh Kwang-Huei Lin The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma
description	Abstract Anaplastic large-cell lymphoma (ALCL) is a rare type of highly malignant, non-Hodgkin lymphoma (NHL). Currently, only studies on the chimeric oncogene NPM-ALK have reported a link to ALCL progression. However, the specific molecular mechanisms underlying the invasion of ALCL are still unclear. Here, we sought to investigate differentially expressed, long non-coding RNAs (lncRNAs) in ALCL and their potential biological function. Our microarray analyses revealed that LINC01013, a novel non-coding RNA gene, was highly expressed in clinical specimens of ALCL and was significantly upregulated in invasive ALCL cell lines. Knockdown of LINC01013 suppressed tumor cell invasion; conversely, its overexpression enhanced tumor cell invasion. LINC01013-induced invasion was mediated by activation of the epithelial-to-mesenchymal transition (EMT)-associated proteins, snail and fibronectin. Specifically, LINC01013 induced snail, resulting in activation of fibronectin and enhanced ALCL cell invasion. Collectively, these findings support a potential role for LINC01013 in cancer cell invasion through the snail-fibronectin activation cascade and suggest that LINC01013 could potentially be utilized as a metastasis marker in ALCL.
format	article
author	I-Hsiao Chung Pei-Hsuan Lu Yang-Hsiang Lin Ming-Ming Tsai Yun-Wen Lin Chau-Ting Yeh Kwang-Huei Lin
author_facet	I-Hsiao Chung Pei-Hsuan Lu Yang-Hsiang Lin Ming-Ming Tsai Yun-Wen Lin Chau-Ting Yeh Kwang-Huei Lin
author_sort	I-Hsiao Chung
title	The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma
title_short	The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma
title_full	The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma
title_fullStr	The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma
title_full_unstemmed	The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma
title_sort	long non-coding rna linc01013 enhances invasion of human anaplastic large-cell lymphoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7feebdb2f2dd4812a1e17b38d6d1fef3
work_keys_str_mv	AT ihsiaochung thelongnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma AT peihsuanlu thelongnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma AT yanghsianglin thelongnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma AT mingmingtsai thelongnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma AT yunwenlin thelongnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma AT chautingyeh thelongnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma AT kwanghueilin thelongnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma AT ihsiaochung longnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma AT peihsuanlu longnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma AT yanghsianglin longnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma AT mingmingtsai longnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma AT yunwenlin longnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma AT chautingyeh longnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma AT kwanghueilin longnoncodingrnalinc01013enhancesinvasionofhumananaplasticlargecelllymphoma
_version_	1718388524123684864

The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma

Ejemplares similares