Targeted nonviral gene therapy in prostate cancer

Najla Altwaijry, Sukrut Somani, Christine Dufès Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK Abstract: Prostate cancer is the second-most widespread cancer in men worldwide. Treatment choices are limited to prostatectomy, hormonal the...

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Main Authors:	Altwaijry N, Somani S, Dufès C
Format:	article
Language:	EN
Published:	Dove Medical Press 2018
Subjects:	Prostate cancer therapy gene delivery tumor targeting nanomedicine Medicine (General) R5-920
Online Access:	https://doaj.org/article/7ff1084383ee4c64a7428c8fbc133b8a
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id	oai:doaj.org-article:7ff1084383ee4c64a7428c8fbc133b8a
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spelling	oai:doaj.org-article:7ff1084383ee4c64a7428c8fbc133b8a2021-12-02T02:58:02ZTargeted nonviral gene therapy in prostate cancer1178-2013https://doaj.org/article/7ff1084383ee4c64a7428c8fbc133b8a2018-09-01T00:00:00Zhttps://www.dovepress.com/targeted-nonviral-gene-therapy-in-prostate-cancer-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Najla Altwaijry, Sukrut Somani, Christine Dufès Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK Abstract: Prostate cancer is the second-most widespread cancer in men worldwide. Treatment choices are limited to prostatectomy, hormonal therapy, and radiotherapy, which commonly have deleterious side effects and vary in their efficacy, depending on the stage of the disease. Among novel experimental strategies, gene therapy holds great promise for the treatment of prostate cancer. However, its use is currently limited by the lack of delivery systems able to selectively deliver the therapeutic genes to the tumors after intravenous administration without major drawbacks. To remediate this problem, a wide range of nonviral delivery approaches have been developed to specifically deliver DNA-based therapeutic agents to their site of action. This review provides an overview of the various nonviral delivery strategies and gene therapy concepts used to deliver therapeutic DNA to prostate cancer cells, and focuses on recent therapeutic advances made so far. Keywords: prostate cancer therapy, gene delivery, tumor targeting, nanomedicineAltwaijry NSomani SDufès CDove Medical PressarticleProstate cancer therapygene deliverytumor targetingnanomedicineMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5753-5767 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prostate cancer therapy gene delivery tumor targeting nanomedicine Medicine (General) R5-920
spellingShingle	Prostate cancer therapy gene delivery tumor targeting nanomedicine Medicine (General) R5-920 Altwaijry N Somani S Dufès C Targeted nonviral gene therapy in prostate cancer
description	Najla Altwaijry, Sukrut Somani, Christine Dufès Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK Abstract: Prostate cancer is the second-most widespread cancer in men worldwide. Treatment choices are limited to prostatectomy, hormonal therapy, and radiotherapy, which commonly have deleterious side effects and vary in their efficacy, depending on the stage of the disease. Among novel experimental strategies, gene therapy holds great promise for the treatment of prostate cancer. However, its use is currently limited by the lack of delivery systems able to selectively deliver the therapeutic genes to the tumors after intravenous administration without major drawbacks. To remediate this problem, a wide range of nonviral delivery approaches have been developed to specifically deliver DNA-based therapeutic agents to their site of action. This review provides an overview of the various nonviral delivery strategies and gene therapy concepts used to deliver therapeutic DNA to prostate cancer cells, and focuses on recent therapeutic advances made so far. Keywords: prostate cancer therapy, gene delivery, tumor targeting, nanomedicine
format	article
author	Altwaijry N Somani S Dufès C
author_facet	Altwaijry N Somani S Dufès C
author_sort	Altwaijry N
title	Targeted nonviral gene therapy in prostate cancer
title_short	Targeted nonviral gene therapy in prostate cancer
title_full	Targeted nonviral gene therapy in prostate cancer
title_fullStr	Targeted nonviral gene therapy in prostate cancer
title_full_unstemmed	Targeted nonviral gene therapy in prostate cancer
title_sort	targeted nonviral gene therapy in prostate cancer
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/7ff1084383ee4c64a7428c8fbc133b8a
work_keys_str_mv	AT altwaijryn targetednonviralgenetherapyinprostatecancer AT somanis targetednonviralgenetherapyinprostatecancer AT dufesc targetednonviralgenetherapyinprostatecancer
_version_	1718402051579314176

Targeted nonviral gene therapy in prostate cancer

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