Targeted nonviral gene therapy in prostate cancer

Najla Altwaijry, Sukrut Somani, Christine Dufès Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK Abstract: Prostate cancer is the second-most widespread cancer in men worldwide. Treatment choices are limited to prostatectomy, hormonal the...

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Autores principales: Altwaijry N, Somani S, Dufès C
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Lenguaje:EN
Publicado: Dove Medical Press 2018
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Acceso en línea:https://doaj.org/article/7ff1084383ee4c64a7428c8fbc133b8a
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spelling oai:doaj.org-article:7ff1084383ee4c64a7428c8fbc133b8a2021-12-02T02:58:02ZTargeted nonviral gene therapy in prostate cancer1178-2013https://doaj.org/article/7ff1084383ee4c64a7428c8fbc133b8a2018-09-01T00:00:00Zhttps://www.dovepress.com/targeted-nonviral-gene-therapy-in-prostate-cancer-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Najla Altwaijry, Sukrut Somani, Christine Dufès Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK Abstract: Prostate cancer is the second-most widespread cancer in men worldwide. Treatment choices are limited to prostatectomy, hormonal therapy, and radiotherapy, which commonly have deleterious side effects and vary in their efficacy, depending on the stage of the disease. Among novel experimental strategies, gene therapy holds great promise for the treatment of prostate cancer. However, its use is currently limited by the lack of delivery systems able to selectively deliver the therapeutic genes to the tumors after intravenous administration without major drawbacks. To remediate this problem, a wide range of nonviral delivery approaches have been developed to specifically deliver DNA-based therapeutic agents to their site of action. This review provides an overview of the various nonviral delivery strategies and gene therapy concepts used to deliver therapeutic DNA to prostate cancer cells, and focuses on recent therapeutic advances made so far. Keywords: prostate cancer therapy, gene delivery, tumor targeting, nanomedicineAltwaijry NSomani SDufès CDove Medical PressarticleProstate cancer therapygene deliverytumor targetingnanomedicineMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5753-5767 (2018)
institution DOAJ
collection DOAJ
language EN
topic Prostate cancer therapy
gene delivery
tumor targeting
nanomedicine
Medicine (General)
R5-920
spellingShingle Prostate cancer therapy
gene delivery
tumor targeting
nanomedicine
Medicine (General)
R5-920
Altwaijry N
Somani S
Dufès C
Targeted nonviral gene therapy in prostate cancer
description Najla Altwaijry, Sukrut Somani, Christine Dufès Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK Abstract: Prostate cancer is the second-most widespread cancer in men worldwide. Treatment choices are limited to prostatectomy, hormonal therapy, and radiotherapy, which commonly have deleterious side effects and vary in their efficacy, depending on the stage of the disease. Among novel experimental strategies, gene therapy holds great promise for the treatment of prostate cancer. However, its use is currently limited by the lack of delivery systems able to selectively deliver the therapeutic genes to the tumors after intravenous administration without major drawbacks. To remediate this problem, a wide range of nonviral delivery approaches have been developed to specifically deliver DNA-based therapeutic agents to their site of action. This review provides an overview of the various nonviral delivery strategies and gene therapy concepts used to deliver therapeutic DNA to prostate cancer cells, and focuses on recent therapeutic advances made so far. Keywords: prostate cancer therapy, gene delivery, tumor targeting, nanomedicine
format article
author Altwaijry N
Somani S
Dufès C
author_facet Altwaijry N
Somani S
Dufès C
author_sort Altwaijry N
title Targeted nonviral gene therapy in prostate cancer
title_short Targeted nonviral gene therapy in prostate cancer
title_full Targeted nonviral gene therapy in prostate cancer
title_fullStr Targeted nonviral gene therapy in prostate cancer
title_full_unstemmed Targeted nonviral gene therapy in prostate cancer
title_sort targeted nonviral gene therapy in prostate cancer
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/7ff1084383ee4c64a7428c8fbc133b8a
work_keys_str_mv AT altwaijryn targetednonviralgenetherapyinprostatecancer
AT somanis targetednonviralgenetherapyinprostatecancer
AT dufesc targetednonviralgenetherapyinprostatecancer
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