Potential Biomarkers of Metastasizing Paragangliomas and Pheochromocytomas

Paragangliomas and pheochromocytomas (PPGLs) are rare neuroendocrine tumors originating from paraganglionic tissue in many sites of the body. Most PPGLs are characterized by nonaggressive behavior but all of them have the potential to metastasize. PPGLs represent a great diagnostic dilemma as it is...

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Autores principales:	Anastasiya Snezhkina, Vladislav Pavlov, Alexey Dmitriev, Nataliya Melnikova, Anna Kudryavtseva
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	paragangliomas and pheochromocytomas head and neck paragangliomas malignancy diagnostic and prognostic markers Science Q
Acceso en línea:	https://doaj.org/article/7ff12d2a350945e09674cd7bf5492b9b
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spelling	oai:doaj.org-article:7ff12d2a350945e09674cd7bf5492b9b2021-11-25T18:10:56ZPotential Biomarkers of Metastasizing Paragangliomas and Pheochromocytomas10.3390/life111111792075-1729https://doaj.org/article/7ff12d2a350945e09674cd7bf5492b9b2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1179https://doaj.org/toc/2075-1729Paragangliomas and pheochromocytomas (PPGLs) are rare neuroendocrine tumors originating from paraganglionic tissue in many sites of the body. Most PPGLs are characterized by nonaggressive behavior but all of them have the potential to metastasize. PPGLs represent a great diagnostic dilemma as it is difficult to recognize tumors that are likely to be metastasizing; criteria of malignancy can be found both in benign and metastatic forms. This review aims to analyze the current knowledge of the nature of metastasizing PPGLs paying particular attention to head and neck paragangliomas (HNPGLs). Potential predictors of the malignancy risk for PPGLs were summarized and discussed. These data may also help in the development of diagnostic and prognostic strategies, as well as in the identification of novel potential therapeutic targets for patients with PPGLs.Anastasiya SnezhkinaVladislav PavlovAlexey DmitrievNataliya MelnikovaAnna KudryavtsevaMDPI AGarticleparagangliomas and pheochromocytomashead and neck paragangliomasmalignancydiagnostic and prognostic markersScienceQENLife, Vol 11, Iss 1179, p 1179 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	paragangliomas and pheochromocytomas head and neck paragangliomas malignancy diagnostic and prognostic markers Science Q
spellingShingle	paragangliomas and pheochromocytomas head and neck paragangliomas malignancy diagnostic and prognostic markers Science Q Anastasiya Snezhkina Vladislav Pavlov Alexey Dmitriev Nataliya Melnikova Anna Kudryavtseva Potential Biomarkers of Metastasizing Paragangliomas and Pheochromocytomas
description	Paragangliomas and pheochromocytomas (PPGLs) are rare neuroendocrine tumors originating from paraganglionic tissue in many sites of the body. Most PPGLs are characterized by nonaggressive behavior but all of them have the potential to metastasize. PPGLs represent a great diagnostic dilemma as it is difficult to recognize tumors that are likely to be metastasizing; criteria of malignancy can be found both in benign and metastatic forms. This review aims to analyze the current knowledge of the nature of metastasizing PPGLs paying particular attention to head and neck paragangliomas (HNPGLs). Potential predictors of the malignancy risk for PPGLs were summarized and discussed. These data may also help in the development of diagnostic and prognostic strategies, as well as in the identification of novel potential therapeutic targets for patients with PPGLs.
format	article
author	Anastasiya Snezhkina Vladislav Pavlov Alexey Dmitriev Nataliya Melnikova Anna Kudryavtseva
author_facet	Anastasiya Snezhkina Vladislav Pavlov Alexey Dmitriev Nataliya Melnikova Anna Kudryavtseva
author_sort	Anastasiya Snezhkina
title	Potential Biomarkers of Metastasizing Paragangliomas and Pheochromocytomas
title_short	Potential Biomarkers of Metastasizing Paragangliomas and Pheochromocytomas
title_full	Potential Biomarkers of Metastasizing Paragangliomas and Pheochromocytomas
title_fullStr	Potential Biomarkers of Metastasizing Paragangliomas and Pheochromocytomas
title_full_unstemmed	Potential Biomarkers of Metastasizing Paragangliomas and Pheochromocytomas
title_sort	potential biomarkers of metastasizing paragangliomas and pheochromocytomas
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7ff12d2a350945e09674cd7bf5492b9b
work_keys_str_mv	AT anastasiyasnezhkina potentialbiomarkersofmetastasizingparagangliomasandpheochromocytomas AT vladislavpavlov potentialbiomarkersofmetastasizingparagangliomasandpheochromocytomas AT alexeydmitriev potentialbiomarkersofmetastasizingparagangliomasandpheochromocytomas AT nataliyamelnikova potentialbiomarkersofmetastasizingparagangliomasandpheochromocytomas AT annakudryavtseva potentialbiomarkersofmetastasizingparagangliomasandpheochromocytomas
_version_	1718411506388828160

Potential Biomarkers of Metastasizing Paragangliomas and Pheochromocytomas

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