Mayaro Virus Induction of Oxidative Stress is Associated With Liver Pathology in a Non-Lethal Mouse Model
Abstract Mayaro virus (MAYV) causes Mayaro fever in humans, a self-limiting acute disease, with persistent arthralgia and arthritis. Although MAYV has a remerging potential, its pathogenic mechanisms remain unclear. Here, we characterized a model of MAYV infection in 3–4-week BALB/c mice. We investi...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/7ff575f4738741d8aade49ceaa0747af |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:7ff575f4738741d8aade49ceaa0747af |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:7ff575f4738741d8aade49ceaa0747af2021-12-02T15:10:02ZMayaro Virus Induction of Oxidative Stress is Associated With Liver Pathology in a Non-Lethal Mouse Model10.1038/s41598-019-51713-92045-2322https://doaj.org/article/7ff575f4738741d8aade49ceaa0747af2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-51713-9https://doaj.org/toc/2045-2322Abstract Mayaro virus (MAYV) causes Mayaro fever in humans, a self-limiting acute disease, with persistent arthralgia and arthritis. Although MAYV has a remerging potential, its pathogenic mechanisms remain unclear. Here, we characterized a model of MAYV infection in 3–4-week BALB/c mice. We investigated whether the liver acts as a site of viral replication and if the infection could cause histopathological alterations and an imbalance in redox homeostasis, culminating with oxidative stress. MAYV-infected mice revealed lower weight gain; however, the disease was self-resolving. High virus titre, neutralizing antibodies, and increased levels of aspartate and alanine aminotransferases were detected in the serum. Infectious viral particles were recovered in the liver of infected animals and the histological examination of liver tissues revealed significant increase in the inflammatory infiltrate. MAYV induced significant oxidative stress in the liver of infected animals, as well as a deregulation of enzymatic antioxidant components. Collectively, this is the first study to report that oxidative stress occurs in MAYV infection in vivo, and that it may be crucial in virus pathogenesis. Future studies are warranted to address the alternative therapeutic strategies for Mayaro fever, such as those based on antioxidant compounds.Camila Carla da Silva CaetanoFernanda Caetano CaminiLetícia Trindade AlmeidaAriane Coelho FerrazTales Fernando da SilvaRafaela Lameira Souza LimaMayara Medeiros de Freitas CarvalhoThalles de Freitas CastroCláudia Martins CarneiroBreno de Mello SilvaSilvana de Queiroz SilvaJosé Carlos de MagalhãesCintia Lopes de Brito MagalhãesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Camila Carla da Silva Caetano Fernanda Caetano Camini Letícia Trindade Almeida Ariane Coelho Ferraz Tales Fernando da Silva Rafaela Lameira Souza Lima Mayara Medeiros de Freitas Carvalho Thalles de Freitas Castro Cláudia Martins Carneiro Breno de Mello Silva Silvana de Queiroz Silva José Carlos de Magalhães Cintia Lopes de Brito Magalhães Mayaro Virus Induction of Oxidative Stress is Associated With Liver Pathology in a Non-Lethal Mouse Model |
| description |
Abstract Mayaro virus (MAYV) causes Mayaro fever in humans, a self-limiting acute disease, with persistent arthralgia and arthritis. Although MAYV has a remerging potential, its pathogenic mechanisms remain unclear. Here, we characterized a model of MAYV infection in 3–4-week BALB/c mice. We investigated whether the liver acts as a site of viral replication and if the infection could cause histopathological alterations and an imbalance in redox homeostasis, culminating with oxidative stress. MAYV-infected mice revealed lower weight gain; however, the disease was self-resolving. High virus titre, neutralizing antibodies, and increased levels of aspartate and alanine aminotransferases were detected in the serum. Infectious viral particles were recovered in the liver of infected animals and the histological examination of liver tissues revealed significant increase in the inflammatory infiltrate. MAYV induced significant oxidative stress in the liver of infected animals, as well as a deregulation of enzymatic antioxidant components. Collectively, this is the first study to report that oxidative stress occurs in MAYV infection in vivo, and that it may be crucial in virus pathogenesis. Future studies are warranted to address the alternative therapeutic strategies for Mayaro fever, such as those based on antioxidant compounds. |
| format |
article |
| author |
Camila Carla da Silva Caetano Fernanda Caetano Camini Letícia Trindade Almeida Ariane Coelho Ferraz Tales Fernando da Silva Rafaela Lameira Souza Lima Mayara Medeiros de Freitas Carvalho Thalles de Freitas Castro Cláudia Martins Carneiro Breno de Mello Silva Silvana de Queiroz Silva José Carlos de Magalhães Cintia Lopes de Brito Magalhães |
| author_facet |
Camila Carla da Silva Caetano Fernanda Caetano Camini Letícia Trindade Almeida Ariane Coelho Ferraz Tales Fernando da Silva Rafaela Lameira Souza Lima Mayara Medeiros de Freitas Carvalho Thalles de Freitas Castro Cláudia Martins Carneiro Breno de Mello Silva Silvana de Queiroz Silva José Carlos de Magalhães Cintia Lopes de Brito Magalhães |
| author_sort |
Camila Carla da Silva Caetano |
| title |
Mayaro Virus Induction of Oxidative Stress is Associated With Liver Pathology in a Non-Lethal Mouse Model |
| title_short |
Mayaro Virus Induction of Oxidative Stress is Associated With Liver Pathology in a Non-Lethal Mouse Model |
| title_full |
Mayaro Virus Induction of Oxidative Stress is Associated With Liver Pathology in a Non-Lethal Mouse Model |
| title_fullStr |
Mayaro Virus Induction of Oxidative Stress is Associated With Liver Pathology in a Non-Lethal Mouse Model |
| title_full_unstemmed |
Mayaro Virus Induction of Oxidative Stress is Associated With Liver Pathology in a Non-Lethal Mouse Model |
| title_sort |
mayaro virus induction of oxidative stress is associated with liver pathology in a non-lethal mouse model |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/7ff575f4738741d8aade49ceaa0747af |
| work_keys_str_mv |
AT camilacarladasilvacaetano mayarovirusinductionofoxidativestressisassociatedwithliverpathologyinanonlethalmousemodel AT fernandacaetanocamini mayarovirusinductionofoxidativestressisassociatedwithliverpathologyinanonlethalmousemodel AT leticiatrindadealmeida mayarovirusinductionofoxidativestressisassociatedwithliverpathologyinanonlethalmousemodel AT arianecoelhoferraz mayarovirusinductionofoxidativestressisassociatedwithliverpathologyinanonlethalmousemodel AT talesfernandodasilva mayarovirusinductionofoxidativestressisassociatedwithliverpathologyinanonlethalmousemodel AT rafaelalameirasouzalima mayarovirusinductionofoxidativestressisassociatedwithliverpathologyinanonlethalmousemodel AT mayaramedeirosdefreitascarvalho mayarovirusinductionofoxidativestressisassociatedwithliverpathologyinanonlethalmousemodel AT thallesdefreitascastro mayarovirusinductionofoxidativestressisassociatedwithliverpathologyinanonlethalmousemodel AT claudiamartinscarneiro mayarovirusinductionofoxidativestressisassociatedwithliverpathologyinanonlethalmousemodel AT brenodemellosilva mayarovirusinductionofoxidativestressisassociatedwithliverpathologyinanonlethalmousemodel AT silvanadequeirozsilva mayarovirusinductionofoxidativestressisassociatedwithliverpathologyinanonlethalmousemodel AT josecarlosdemagalhaes mayarovirusinductionofoxidativestressisassociatedwithliverpathologyinanonlethalmousemodel AT cintialopesdebritomagalhaes mayarovirusinductionofoxidativestressisassociatedwithliverpathologyinanonlethalmousemodel |
| _version_ |
1718387762048008192 |