Transcriptional activators of human genes with programmable DNA-specificity.

TAL (transcription activator-like) effectors are translocated by Xanthomonas bacteria into plant cells where they activate transcription of target genes. DNA target sequence recognition occurs in a unique mode involving a central domain of tandem repeats. Each repeat recognizes a single base pair in...

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Autores principales: René Geissler, Heidi Scholze, Simone Hahn, Jana Streubel, Ulla Bonas, Sven-Erik Behrens, Jens Boch
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/7ff6afeaea36486f9008c321137fc741
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