Continuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea

Chung-Chieh Yu,1–3 Chih-Yu Huang,1–3 Wei-Ke Kuo,1–3 Chung-Yao Chen2,4 1Division of Pulmonary Critical Care and Sleep Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan; 2Department of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Tai...

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Autores principales:	Yu CC, Huang CY, Kuo WK, Chen CY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Obstructive sleep apnea ischemic stroke nocturia Continuous positive airway pressure Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7ff712c4465446a795d9c1ebe05bebaa
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spelling	oai:doaj.org-article:7ff712c4465446a795d9c1ebe05bebaa2021-12-02T02:22:47ZContinuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea1178-1998https://doaj.org/article/7ff712c4465446a795d9c1ebe05bebaa2019-01-01T00:00:00Zhttps://www.dovepress.com/continuous-positive-airway-pressure-improves-nocturnal-polyuria-in-isc-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Chung-Chieh Yu,1–3 Chih-Yu Huang,1–3 Wei-Ke Kuo,1–3 Chung-Yao Chen2,4 1Division of Pulmonary Critical Care and Sleep Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan; 2Department of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan; 3Department of Respiratory Therapy, Chang Gung Memorial Hospital, Keelung, Taiwan; 4Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Keelung, Taiwan Objectives: To assess the effect of continuous positive airway pressure (CPAP) on nocturia in ischemic stroke patients with obstructive sleep apnea (OSA).Methods: This was a prospective and non-randomized controlled study in which ischemic stroke patients with OSA being treated in a rehabilitation ward were enrolled. The participants who tolerated CPAP were classified as the CPAP group, while those who refused or could not tolerate CPAP were classified as the control group. The percentage change of nocturia before and after 2 weeks of CPAP therapy between the two groups were compared.Results: A total of 44 participants were enrolled in and 35 participants (mean age=59.8±11.7 years old; mean apnea hypopnea index=42.9±16.7/h) completed the study (control group: 14, CPAP group: 21). Overall, 69% of the participants had nocturnal polyuria and 69% of them had more than one nocturia episode per night. The baseline and initial nocturia characteristics did not differ significantly between the two groups. As compared to the control group, CPAP therapy significantly decreased the nocturnal polyuria index (mean percentage change: 9% vs -21% (P=0.005)) and nocturnal urine output (mean percentage change: 6% vs -26% (P=0.04)), but not the nocturia episodes or 24-hours total urine output.Conclusion: Nocturia due to nocturnal polyuria is very common in post-stroke patients with OSA. Treating OSA by CPAP significantly reduces nocturnal polyuria, but not nocturia frequency, in ischemic stroke patients. Keywords: nocturia, nocturnal polyuria index, nocturnal urine output, multiple comorbidities  Yu CCHuang CYKuo WKChen CYDove Medical PressarticleObstructive sleep apneaischemic strokenocturiaContinuous positive airway pressureGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 241-247 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obstructive sleep apnea ischemic stroke nocturia Continuous positive airway pressure Geriatrics RC952-954.6
spellingShingle	Obstructive sleep apnea ischemic stroke nocturia Continuous positive airway pressure Geriatrics RC952-954.6 Yu CC Huang CY Kuo WK Chen CY Continuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea
description	Chung-Chieh Yu,1–3 Chih-Yu Huang,1–3 Wei-Ke Kuo,1–3 Chung-Yao Chen2,4 1Division of Pulmonary Critical Care and Sleep Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan; 2Department of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan; 3Department of Respiratory Therapy, Chang Gung Memorial Hospital, Keelung, Taiwan; 4Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Keelung, Taiwan Objectives: To assess the effect of continuous positive airway pressure (CPAP) on nocturia in ischemic stroke patients with obstructive sleep apnea (OSA).Methods: This was a prospective and non-randomized controlled study in which ischemic stroke patients with OSA being treated in a rehabilitation ward were enrolled. The participants who tolerated CPAP were classified as the CPAP group, while those who refused or could not tolerate CPAP were classified as the control group. The percentage change of nocturia before and after 2 weeks of CPAP therapy between the two groups were compared.Results: A total of 44 participants were enrolled in and 35 participants (mean age=59.8±11.7 years old; mean apnea hypopnea index=42.9±16.7/h) completed the study (control group: 14, CPAP group: 21). Overall, 69% of the participants had nocturnal polyuria and 69% of them had more than one nocturia episode per night. The baseline and initial nocturia characteristics did not differ significantly between the two groups. As compared to the control group, CPAP therapy significantly decreased the nocturnal polyuria index (mean percentage change: 9% vs -21% (P=0.005)) and nocturnal urine output (mean percentage change: 6% vs -26% (P=0.04)), but not the nocturia episodes or 24-hours total urine output.Conclusion: Nocturia due to nocturnal polyuria is very common in post-stroke patients with OSA. Treating OSA by CPAP significantly reduces nocturnal polyuria, but not nocturia frequency, in ischemic stroke patients. Keywords: nocturia, nocturnal polyuria index, nocturnal urine output, multiple comorbidities
format	article
author	Yu CC Huang CY Kuo WK Chen CY
author_facet	Yu CC Huang CY Kuo WK Chen CY
author_sort	Yu CC
title	Continuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea
title_short	Continuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea
title_full	Continuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea
title_fullStr	Continuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea
title_full_unstemmed	Continuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea
title_sort	continuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/7ff712c4465446a795d9c1ebe05bebaa
work_keys_str_mv	AT yucc continuouspositiveairwaypressureimprovesnocturnalpolyuriainischemicstrokepatientswithobstructivesleepapnea AT huangcy continuouspositiveairwaypressureimprovesnocturnalpolyuriainischemicstrokepatientswithobstructivesleepapnea AT kuowk continuouspositiveairwaypressureimprovesnocturnalpolyuriainischemicstrokepatientswithobstructivesleepapnea AT chency continuouspositiveairwaypressureimprovesnocturnalpolyuriainischemicstrokepatientswithobstructivesleepapnea
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Continuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea

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