Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial

Abstract Low vitamin D status is associated with increased risk of pneumonia, greater disease severity and poorer outcome. However, no trials have examined the effect of adjunctive vitamin D therapy on outcomes in adults with community-acquired pneumonia (CAP). We conducted a randomised, double-blin...

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Autores principales:	Sandy Slow, Michael Epton, Malina Storer, Rennae Thiessen, Steven Lim, James Wong, Paul Chin, Pleayo Tovaranonte, John Pearson, Stephen T. Chambers, David R. Murdoch, VIDCAPS Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Community-acquired Pneumonia (CAP) Post-treatment Studies Adjunctive Vitamin 25OHD Concentrations Pulmonary Inflammatory Infiltrates Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7ff8b5f79a054564985962657976a4d6
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spelling	oai:doaj.org-article:7ff8b5f79a054564985962657976a4d62021-12-02T15:07:59ZEffect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial10.1038/s41598-018-32162-22045-2322https://doaj.org/article/7ff8b5f79a054564985962657976a4d62018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32162-2https://doaj.org/toc/2045-2322Abstract Low vitamin D status is associated with increased risk of pneumonia, greater disease severity and poorer outcome. However, no trials have examined the effect of adjunctive vitamin D therapy on outcomes in adults with community-acquired pneumonia (CAP). We conducted a randomised, double-blind, placebo-controlled trial examining the effects of adjunctive vitamin D in adults hospitalised with CAP. Participants were randomised to either a single oral dose of 200,000 IU vitamin D3 or placebo. The primary outcome was the complete resolution of chest radiograph infiltrate at 6 weeks post-study treatment. Secondary outcomes included length of hospital stay, intensive care admission and return to normal activity. Only participants who completed the study or died within the 6 week period were included in the analysis (n = 60 vitamin D, n = 57 placebo). Adjunctive vitamin D did not have any effect on the primary outcome (OR 0.78, 95% CI 0.31 to 1.86, p = 0.548). However, there was evidence it increased the complete resolution of pneumonia in participants with baseline vitamin D levels <25 nmol/L (OR 17.0, 95% CI 1.40–549.45, P = 0.043), but this did not reach statistical significance using exact methods (OR 13.0, 95%CI 0.7–960.4, P = 0.083). There were no significant effects for any secondary outcome.Sandy SlowMichael EptonMalina StorerRennae ThiessenSteven LimJames WongPaul ChinPleayo TovaranonteJohn PearsonStephen T. ChambersDavid R. MurdochVIDCAPS GroupNature PortfolioarticleCommunity-acquired Pneumonia (CAP)Post-treatment StudiesAdjunctive Vitamin25OHD ConcentrationsPulmonary Inflammatory InfiltratesMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Community-acquired Pneumonia (CAP) Post-treatment Studies Adjunctive Vitamin 25OHD Concentrations Pulmonary Inflammatory Infiltrates Medicine R Science Q
spellingShingle	Community-acquired Pneumonia (CAP) Post-treatment Studies Adjunctive Vitamin 25OHD Concentrations Pulmonary Inflammatory Infiltrates Medicine R Science Q Sandy Slow Michael Epton Malina Storer Rennae Thiessen Steven Lim James Wong Paul Chin Pleayo Tovaranonte John Pearson Stephen T. Chambers David R. Murdoch VIDCAPS Group Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial
description	Abstract Low vitamin D status is associated with increased risk of pneumonia, greater disease severity and poorer outcome. However, no trials have examined the effect of adjunctive vitamin D therapy on outcomes in adults with community-acquired pneumonia (CAP). We conducted a randomised, double-blind, placebo-controlled trial examining the effects of adjunctive vitamin D in adults hospitalised with CAP. Participants were randomised to either a single oral dose of 200,000 IU vitamin D3 or placebo. The primary outcome was the complete resolution of chest radiograph infiltrate at 6 weeks post-study treatment. Secondary outcomes included length of hospital stay, intensive care admission and return to normal activity. Only participants who completed the study or died within the 6 week period were included in the analysis (n = 60 vitamin D, n = 57 placebo). Adjunctive vitamin D did not have any effect on the primary outcome (OR 0.78, 95% CI 0.31 to 1.86, p = 0.548). However, there was evidence it increased the complete resolution of pneumonia in participants with baseline vitamin D levels <25 nmol/L (OR 17.0, 95% CI 1.40–549.45, P = 0.043), but this did not reach statistical significance using exact methods (OR 13.0, 95%CI 0.7–960.4, P = 0.083). There were no significant effects for any secondary outcome.
format	article
author	Sandy Slow Michael Epton Malina Storer Rennae Thiessen Steven Lim James Wong Paul Chin Pleayo Tovaranonte John Pearson Stephen T. Chambers David R. Murdoch VIDCAPS Group
author_facet	Sandy Slow Michael Epton Malina Storer Rennae Thiessen Steven Lim James Wong Paul Chin Pleayo Tovaranonte John Pearson Stephen T. Chambers David R. Murdoch VIDCAPS Group
author_sort	Sandy Slow
title	Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial
title_short	Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial
title_full	Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial
title_fullStr	Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial
title_full_unstemmed	Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial
title_sort	effect of adjunctive single high-dose vitamin d3 on outcome of community-acquired pneumonia in hospitalised adults: the vidcaps randomised controlled trial
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7ff8b5f79a054564985962657976a4d6
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Effect of adjunctive single high-dose vitamin D3 on outcome of community-acquired pneumonia in hospitalised adults: The VIDCAPS randomised controlled trial

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