ArfB can displace mRNA to rescue stalled ribosomes

Alternative rescue factor B (ArfB) is an enzyme that releases peptides from stalled ribosomes to allow ribosome recycling. Here the authors carry-out cryo-EM analyses of 70S ribosomes complexed with ArfB on either a short or longer mRNA to reveal distinct modes of ArfB function.

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Detalles Bibliográficos
Autores principales: Christine E. Carbone, Gabriel Demo, Rohini Madireddy, Egor Svidritskiy, Andrei A. Korostelev
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/7ffabda129144820b3a56d356ee51d8b
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Descripción
Sumario:Alternative rescue factor B (ArfB) is an enzyme that releases peptides from stalled ribosomes to allow ribosome recycling. Here the authors carry-out cryo-EM analyses of 70S ribosomes complexed with ArfB on either a short or longer mRNA to reveal distinct modes of ArfB function.