Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes

The spike protein of coronaviruses (S-protein) is an envelope-anchored trimeric type I transmembrane glycoprotein that mediates receptor binding and the fusion of the viral and host cell membranes. Here the authors report the conformational states of HCoV-229E S trimer and observe the conformational...

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Autores principales:	Xiyong Song, Yuejun Shi, Wei Ding, Tongxin Niu, Limeng Sun, Yubei Tan, Yong Chen, Jiale Shi, Qiqi Xiong, Xiaojun Huang, Shaobo Xiao, Yanping Zhu, Chongyun Cheng, Zhen F. Fu, Zhi-Jie Liu, Guiqing Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ffb884ec3014efeb8e143e4317d77ea
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spelling	oai:doaj.org-article:7ffb884ec3014efeb8e143e4317d77ea2021-12-02T15:08:00ZCryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes10.1038/s41467-020-20401-y2041-1723https://doaj.org/article/7ffb884ec3014efeb8e143e4317d77ea2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20401-yhttps://doaj.org/toc/2041-1723The spike protein of coronaviruses (S-protein) is an envelope-anchored trimeric type I transmembrane glycoprotein that mediates receptor binding and the fusion of the viral and host cell membranes. Here the authors report the conformational states of HCoV-229E S trimer and observe the conformational changes in S1 subunit from closed state to activated state for receptor binding.Xiyong SongYuejun ShiWei DingTongxin NiuLimeng SunYubei TanYong ChenJiale ShiQiqi XiongXiaojun HuangShaobo XiaoYanping ZhuChongyun ChengZhen F. FuZhi-Jie LiuGuiqing PengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiyong Song Yuejun Shi Wei Ding Tongxin Niu Limeng Sun Yubei Tan Yong Chen Jiale Shi Qiqi Xiong Xiaojun Huang Shaobo Xiao Yanping Zhu Chongyun Cheng Zhen F. Fu Zhi-Jie Liu Guiqing Peng Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes
description	The spike protein of coronaviruses (S-protein) is an envelope-anchored trimeric type I transmembrane glycoprotein that mediates receptor binding and the fusion of the viral and host cell membranes. Here the authors report the conformational states of HCoV-229E S trimer and observe the conformational changes in S1 subunit from closed state to activated state for receptor binding.
format	article
author	Xiyong Song Yuejun Shi Wei Ding Tongxin Niu Limeng Sun Yubei Tan Yong Chen Jiale Shi Qiqi Xiong Xiaojun Huang Shaobo Xiao Yanping Zhu Chongyun Cheng Zhen F. Fu Zhi-Jie Liu Guiqing Peng
author_facet	Xiyong Song Yuejun Shi Wei Ding Tongxin Niu Limeng Sun Yubei Tan Yong Chen Jiale Shi Qiqi Xiong Xiaojun Huang Shaobo Xiao Yanping Zhu Chongyun Cheng Zhen F. Fu Zhi-Jie Liu Guiqing Peng
author_sort	Xiyong Song
title	Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes
title_short	Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes
title_full	Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes
title_fullStr	Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes
title_full_unstemmed	Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes
title_sort	cryo-em analysis of the hcov-229e spike glycoprotein reveals dynamic prefusion conformational changes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7ffb884ec3014efeb8e143e4317d77ea
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Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes

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