The effect of local immunity on gastric cancer prognosis

Aim. To study the state of local immunity in patients with gastric adenocarcinoma. Materials and methods. From 2017 to 2018, 45 previously untreated patients with gastric adenocarcinoma (25 with stage IIII, 20 with stage IV) received surgical/combined treatment or chemotherapy, respectively, at t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gulnoz G. Khakimova, Alexey A. Tryakin, Tatyana N. Zabotina, Anna A. Borunova, Olga A. Malikhova, Farruh M. Juraev, Ivan N. Peregorodiev, Elena N. Zaharova, Dmitriy V. Tabakov
Formato:	article
Lenguaje:	RU
Publicado:	IP Habib O.N. 2020
Materias:	gastric adenocarcinoma local immunity subpopulations of lymphocytes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7ffbdcd2936c4c7a845bd8bd1400fcf8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7ffbdcd2936c4c7a845bd8bd1400fcf8
record_format	dspace
spelling	oai:doaj.org-article:7ffbdcd2936c4c7a845bd8bd1400fcf82021-11-30T17:03:34ZThe effect of local immunity on gastric cancer prognosis1815-14341815-144210.26442/18151434.2020.1.200049https://doaj.org/article/7ffbdcd2936c4c7a845bd8bd1400fcf82020-05-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/34174/22586https://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442Aim. To study the state of local immunity in patients with gastric adenocarcinoma. Materials and methods. From 2017 to 2018, 45 previously untreated patients with gastric adenocarcinoma (25 with stage IIII, 20 with stage IV) received surgical/combined treatment or chemotherapy, respectively, at the Blokhin Scientific Research Center of Oncology. Tumor tissue was taken before treatment. By using flow cytometry there were evaluated the percentage of tumor tissue infiltration by lymphocytes (CD45+CD14-TIL); T cells (CD3+CD19-TIL); B cells (CD3-CD19+TIL); NK cell (CD3-CD16+CD56+TIL); effector cells CD16 (CD16+Perforin+TIL) and CD8 (CD8+Perforin+TIL) with their cytotoxic potential active CD16TIL and active CD8TIL; subpopulations of regulatory T cells NKT cells (CD3+CD16+CD56+TIL), regulatory cells CD4 (CD4+CD25+CD127-TIL) and CD8 (CD8+CD11b-CD28-TIL). The prognostic value of immune cells for overall survival (OS) and progression-free survival (PFS) was assessed. Results. A favorable prognosis factor for progression-free survival in patients with local and locally advanced forms of gastric cancer was an increase in the number of CD3-CD19+TIL (HR 0.862, 95% CI 0.7820.957, p=0.005), and an unfavorable prognosis was an increase in NK cells (CD3-CD16+CD56+TIL); HR 1.382, 95% CI 1.0871.758, p=0.008. The negative effect of the relative content of NK cells (CD3-CD16+CD56+TIL) and NKT cells (CD3+CD16+CD56+TIL) on OS of patients with metastatic gastric cancer noted (HR 1.249, 95% CI 0.9971.564, p=0.053; HR 1.127, 95% CI 1.0251.239, p=0.013). At the same time, an increase in the percentage of tumor tissue infiltration by lymphocytes (CD45+CD14-TIL) and an increase in the age of patients (HR 1.005, 95% CI 1.0021.008, p=0.003; HR 1.098, 95% CI 1.0311.170, p=0.004) reduce the incidence of PFS in patients with metastatic gastric carcinoma. Conclusion. Indices of local immunity can serve as additional prognostic factors for gastric carcinoma.Gulnoz G. KhakimovaAlexey A. TryakinTatyana N. ZabotinaAnna A. BorunovaOlga A. MalikhovaFarruh M. JuraevIvan N. PeregorodievElena N. ZaharovaDmitriy V. TabakovIP Habib O.N.articlegastric adenocarcinomalocal immunitysubpopulations of lymphocytesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 22, Iss 1, Pp 60-65 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	gastric adenocarcinoma local immunity subpopulations of lymphocytes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	gastric adenocarcinoma local immunity subpopulations of lymphocytes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Gulnoz G. Khakimova Alexey A. Tryakin Tatyana N. Zabotina Anna A. Borunova Olga A. Malikhova Farruh M. Juraev Ivan N. Peregorodiev Elena N. Zaharova Dmitriy V. Tabakov The effect of local immunity on gastric cancer prognosis
description	Aim. To study the state of local immunity in patients with gastric adenocarcinoma. Materials and methods. From 2017 to 2018, 45 previously untreated patients with gastric adenocarcinoma (25 with stage IIII, 20 with stage IV) received surgical/combined treatment or chemotherapy, respectively, at the Blokhin Scientific Research Center of Oncology. Tumor tissue was taken before treatment. By using flow cytometry there were evaluated the percentage of tumor tissue infiltration by lymphocytes (CD45+CD14-TIL); T cells (CD3+CD19-TIL); B cells (CD3-CD19+TIL); NK cell (CD3-CD16+CD56+TIL); effector cells CD16 (CD16+Perforin+TIL) and CD8 (CD8+Perforin+TIL) with their cytotoxic potential active CD16TIL and active CD8TIL; subpopulations of regulatory T cells NKT cells (CD3+CD16+CD56+TIL), regulatory cells CD4 (CD4+CD25+CD127-TIL) and CD8 (CD8+CD11b-CD28-TIL). The prognostic value of immune cells for overall survival (OS) and progression-free survival (PFS) was assessed. Results. A favorable prognosis factor for progression-free survival in patients with local and locally advanced forms of gastric cancer was an increase in the number of CD3-CD19+TIL (HR 0.862, 95% CI 0.7820.957, p=0.005), and an unfavorable prognosis was an increase in NK cells (CD3-CD16+CD56+TIL); HR 1.382, 95% CI 1.0871.758, p=0.008. The negative effect of the relative content of NK cells (CD3-CD16+CD56+TIL) and NKT cells (CD3+CD16+CD56+TIL) on OS of patients with metastatic gastric cancer noted (HR 1.249, 95% CI 0.9971.564, p=0.053; HR 1.127, 95% CI 1.0251.239, p=0.013). At the same time, an increase in the percentage of tumor tissue infiltration by lymphocytes (CD45+CD14-TIL) and an increase in the age of patients (HR 1.005, 95% CI 1.0021.008, p=0.003; HR 1.098, 95% CI 1.0311.170, p=0.004) reduce the incidence of PFS in patients with metastatic gastric carcinoma. Conclusion. Indices of local immunity can serve as additional prognostic factors for gastric carcinoma.
format	article
author	Gulnoz G. Khakimova Alexey A. Tryakin Tatyana N. Zabotina Anna A. Borunova Olga A. Malikhova Farruh M. Juraev Ivan N. Peregorodiev Elena N. Zaharova Dmitriy V. Tabakov
author_facet	Gulnoz G. Khakimova Alexey A. Tryakin Tatyana N. Zabotina Anna A. Borunova Olga A. Malikhova Farruh M. Juraev Ivan N. Peregorodiev Elena N. Zaharova Dmitriy V. Tabakov
author_sort	Gulnoz G. Khakimova
title	The effect of local immunity on gastric cancer prognosis
title_short	The effect of local immunity on gastric cancer prognosis
title_full	The effect of local immunity on gastric cancer prognosis
title_fullStr	The effect of local immunity on gastric cancer prognosis
title_full_unstemmed	The effect of local immunity on gastric cancer prognosis
title_sort	effect of local immunity on gastric cancer prognosis
publisher	IP Habib O.N.
publishDate	2020
url	https://doaj.org/article/7ffbdcd2936c4c7a845bd8bd1400fcf8
work_keys_str_mv	AT gulnozgkhakimova theeffectoflocalimmunityongastriccancerprognosis AT alexeyatryakin theeffectoflocalimmunityongastriccancerprognosis AT tatyananzabotina theeffectoflocalimmunityongastriccancerprognosis AT annaaborunova theeffectoflocalimmunityongastriccancerprognosis AT olgaamalikhova theeffectoflocalimmunityongastriccancerprognosis AT farruhmjuraev theeffectoflocalimmunityongastriccancerprognosis AT ivannperegorodiev theeffectoflocalimmunityongastriccancerprognosis AT elenanzaharova theeffectoflocalimmunityongastriccancerprognosis AT dmitriyvtabakov theeffectoflocalimmunityongastriccancerprognosis AT gulnozgkhakimova effectoflocalimmunityongastriccancerprognosis AT alexeyatryakin effectoflocalimmunityongastriccancerprognosis AT tatyananzabotina effectoflocalimmunityongastriccancerprognosis AT annaaborunova effectoflocalimmunityongastriccancerprognosis AT olgaamalikhova effectoflocalimmunityongastriccancerprognosis AT farruhmjuraev effectoflocalimmunityongastriccancerprognosis AT ivannperegorodiev effectoflocalimmunityongastriccancerprognosis AT elenanzaharova effectoflocalimmunityongastriccancerprognosis AT dmitriyvtabakov effectoflocalimmunityongastriccancerprognosis
_version_	1718406389413445632

The effect of local immunity on gastric cancer prognosis

Ejemplares similares