Accuracy of standard clinical 3T prostate MRI for pelvic lymph node staging: Comparison to 68 Ga-PSMA PET-CT

Abstract The aim was to assess the performance of prostate 3T MRI for pelvic lymph node (LN) staging in prostate cancer (PCa), in comparison to 68Gallium-prostate specific membrane antigen PET-CT (68Ga-PSMA PET-CT) as reference standard for LN detection. 130 patients with PCa underwent non-contrast-...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sebastian Meißner, Jan-Carlo Janssen, Vikas Prasad, Gerd Diederichs, Bernd Hamm, Winfried Brenner, Marcus R. Makowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7ffc30d324854905820c7d9b3ee7eba7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7ffc30d324854905820c7d9b3ee7eba7
record_format	dspace
spelling	oai:doaj.org-article:7ffc30d324854905820c7d9b3ee7eba72021-12-02T15:09:15ZAccuracy of standard clinical 3T prostate MRI for pelvic lymph node staging: Comparison to 68 Ga-PSMA PET-CT10.1038/s41598-019-46386-32045-2322https://doaj.org/article/7ffc30d324854905820c7d9b3ee7eba72019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46386-3https://doaj.org/toc/2045-2322Abstract The aim was to assess the performance of prostate 3T MRI for pelvic lymph node (LN) staging in prostate cancer (PCa), in comparison to 68Gallium-prostate specific membrane antigen PET-CT (68Ga-PSMA PET-CT) as reference standard for LN detection. 130 patients with PCa underwent non-contrast-enhanced multiparametric prostate 3T MRI and 68Ga-PSMA-PET-CT within 180 days at our institution. Overall, 187 LN metastases (n = 43 patients) detected by 68Ga-PSMA-PET-CT were characterized by calculating maximum standardized uptake value (SUVmax), area, diameter and anatomical location including iliac, obturator, presacral and inguinal region. MRI achieved an overall sensitivity, specificity, positive and negative predictive value of 81.6% (CI 71.1–88.9%), 98.6% (CI 97.6–99.2%), 73.5% (CI 52.1–87.6%) and 99.5% (CI 98.8–99.8%), respectively. On a region-based analysis, detection rates differed non-significantly (ps > 0.12) in the anatomical regions. On a size-dependent analysis, detection of LN > 10 mm did not differ significantly (ps > 0.09) from LN ≤ 10 mm. In comparison to single T1 sequence evaluation, additional use of the T2 weighted sequences did not improve the overall performance significantly (p > 0.05). 3T prostate MRI represented an accurate tool for the detection of LN compared to 68Ga-PSMA-PET-CT. Especially for LN metastases smaller than 10 mm, MRI was less accurate compared to 68Ga-PSMA-PET-CT.Sebastian MeißnerJan-Carlo JanssenVikas PrasadGerd DiederichsBernd HammWinfried BrennerMarcus R. MakowskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sebastian Meißner Jan-Carlo Janssen Vikas Prasad Gerd Diederichs Bernd Hamm Winfried Brenner Marcus R. Makowski Accuracy of standard clinical 3T prostate MRI for pelvic lymph node staging: Comparison to 68 Ga-PSMA PET-CT
description	Abstract The aim was to assess the performance of prostate 3T MRI for pelvic lymph node (LN) staging in prostate cancer (PCa), in comparison to 68Gallium-prostate specific membrane antigen PET-CT (68Ga-PSMA PET-CT) as reference standard for LN detection. 130 patients with PCa underwent non-contrast-enhanced multiparametric prostate 3T MRI and 68Ga-PSMA-PET-CT within 180 days at our institution. Overall, 187 LN metastases (n = 43 patients) detected by 68Ga-PSMA-PET-CT were characterized by calculating maximum standardized uptake value (SUVmax), area, diameter and anatomical location including iliac, obturator, presacral and inguinal region. MRI achieved an overall sensitivity, specificity, positive and negative predictive value of 81.6% (CI 71.1–88.9%), 98.6% (CI 97.6–99.2%), 73.5% (CI 52.1–87.6%) and 99.5% (CI 98.8–99.8%), respectively. On a region-based analysis, detection rates differed non-significantly (ps > 0.12) in the anatomical regions. On a size-dependent analysis, detection of LN > 10 mm did not differ significantly (ps > 0.09) from LN ≤ 10 mm. In comparison to single T1 sequence evaluation, additional use of the T2 weighted sequences did not improve the overall performance significantly (p > 0.05). 3T prostate MRI represented an accurate tool for the detection of LN compared to 68Ga-PSMA-PET-CT. Especially for LN metastases smaller than 10 mm, MRI was less accurate compared to 68Ga-PSMA-PET-CT.
format	article
author	Sebastian Meißner Jan-Carlo Janssen Vikas Prasad Gerd Diederichs Bernd Hamm Winfried Brenner Marcus R. Makowski
author_facet	Sebastian Meißner Jan-Carlo Janssen Vikas Prasad Gerd Diederichs Bernd Hamm Winfried Brenner Marcus R. Makowski
author_sort	Sebastian Meißner
title	Accuracy of standard clinical 3T prostate MRI for pelvic lymph node staging: Comparison to 68 Ga-PSMA PET-CT
title_short	Accuracy of standard clinical 3T prostate MRI for pelvic lymph node staging: Comparison to 68 Ga-PSMA PET-CT
title_full	Accuracy of standard clinical 3T prostate MRI for pelvic lymph node staging: Comparison to 68 Ga-PSMA PET-CT
title_fullStr	Accuracy of standard clinical 3T prostate MRI for pelvic lymph node staging: Comparison to 68 Ga-PSMA PET-CT
title_full_unstemmed	Accuracy of standard clinical 3T prostate MRI for pelvic lymph node staging: Comparison to 68 Ga-PSMA PET-CT
title_sort	accuracy of standard clinical 3t prostate mri for pelvic lymph node staging: comparison to 68 ga-psma pet-ct
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7ffc30d324854905820c7d9b3ee7eba7
work_keys_str_mv	AT sebastianmeißner accuracyofstandardclinical3tprostatemriforpelviclymphnodestagingcomparisonto68gapsmapetct AT jancarlojanssen accuracyofstandardclinical3tprostatemriforpelviclymphnodestagingcomparisonto68gapsmapetct AT vikasprasad accuracyofstandardclinical3tprostatemriforpelviclymphnodestagingcomparisonto68gapsmapetct AT gerddiederichs accuracyofstandardclinical3tprostatemriforpelviclymphnodestagingcomparisonto68gapsmapetct AT berndhamm accuracyofstandardclinical3tprostatemriforpelviclymphnodestagingcomparisonto68gapsmapetct AT winfriedbrenner accuracyofstandardclinical3tprostatemriforpelviclymphnodestagingcomparisonto68gapsmapetct AT marcusrmakowski accuracyofstandardclinical3tprostatemriforpelviclymphnodestagingcomparisonto68gapsmapetct
_version_	1718387884063457280

Accuracy of standard clinical 3T prostate MRI for pelvic lymph node staging: Comparison to 68 Ga-PSMA PET-CT

Ejemplares similares