Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

Questioning what regulates left-right asymmetry breaking in the mouse node: the authors identify a 200 bp stretch of the Dand5 3’UTR where Bicc1 binds, and Cnot proteins downstream of calcium flow regulate the post-transcriptional regulation of Dand5 by Bicc1.

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Autores principales: Katsura Minegishi, Benjamin Rothé, Kaoru R. Komatsu, Hiroki Ono, Yayoi Ikawa, Hiromi Nishimura, Takanobu A. Katoh, Eriko Kajikawa, Xiaorei Sai, Emi Miyashita, Katsuyoshi Takaoka, Kana Bando, Hiroshi Kiyonari, Tadashi Yamamoto, Hirohide Saito, Daniel B. Constam, Hiroshi Hamada
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7ffc6f067d6c41829dd863e590035f76
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spelling oai:doaj.org-article:7ffc6f067d6c41829dd863e590035f762021-12-02T16:32:13ZFluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex10.1038/s41467-021-24295-22041-1723https://doaj.org/article/7ffc6f067d6c41829dd863e590035f762021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24295-2https://doaj.org/toc/2041-1723Questioning what regulates left-right asymmetry breaking in the mouse node: the authors identify a 200 bp stretch of the Dand5 3’UTR where Bicc1 binds, and Cnot proteins downstream of calcium flow regulate the post-transcriptional regulation of Dand5 by Bicc1.Katsura MinegishiBenjamin RothéKaoru R. KomatsuHiroki OnoYayoi IkawaHiromi NishimuraTakanobu A. KatohEriko KajikawaXiaorei SaiEmi MiyashitaKatsuyoshi TakaokaKana BandoHiroshi KiyonariTadashi YamamotoHirohide SaitoDaniel B. ConstamHiroshi HamadaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Katsura Minegishi
Benjamin Rothé
Kaoru R. Komatsu
Hiroki Ono
Yayoi Ikawa
Hiromi Nishimura
Takanobu A. Katoh
Eriko Kajikawa
Xiaorei Sai
Emi Miyashita
Katsuyoshi Takaoka
Kana Bando
Hiroshi Kiyonari
Tadashi Yamamoto
Hirohide Saito
Daniel B. Constam
Hiroshi Hamada
Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex
description Questioning what regulates left-right asymmetry breaking in the mouse node: the authors identify a 200 bp stretch of the Dand5 3’UTR where Bicc1 binds, and Cnot proteins downstream of calcium flow regulate the post-transcriptional regulation of Dand5 by Bicc1.
format article
author Katsura Minegishi
Benjamin Rothé
Kaoru R. Komatsu
Hiroki Ono
Yayoi Ikawa
Hiromi Nishimura
Takanobu A. Katoh
Eriko Kajikawa
Xiaorei Sai
Emi Miyashita
Katsuyoshi Takaoka
Kana Bando
Hiroshi Kiyonari
Tadashi Yamamoto
Hirohide Saito
Daniel B. Constam
Hiroshi Hamada
author_facet Katsura Minegishi
Benjamin Rothé
Kaoru R. Komatsu
Hiroki Ono
Yayoi Ikawa
Hiromi Nishimura
Takanobu A. Katoh
Eriko Kajikawa
Xiaorei Sai
Emi Miyashita
Katsuyoshi Takaoka
Kana Bando
Hiroshi Kiyonari
Tadashi Yamamoto
Hirohide Saito
Daniel B. Constam
Hiroshi Hamada
author_sort Katsura Minegishi
title Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex
title_short Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex
title_full Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex
title_fullStr Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex
title_full_unstemmed Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex
title_sort fluid flow-induced left-right asymmetric decay of dand5 mrna in the mouse embryo requires a bicc1-ccr4 rna degradation complex
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7ffc6f067d6c41829dd863e590035f76
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