Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution

2-(hetero)aryl N-heteroarenes are ubiquitously applied in numerous fields of science and useful for the development of bioactive molecules and drugs, but there is a lack of general methods for their synthesis. Here, the authors report an iridium(III)-catalyzed method for direct α-arylation of N-hete...

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Autores principales:	Liang Cao, He Zhao, Rongqing Guan, Huanfeng Jiang, Pierre. H. Dixneuf, Min Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ffd9171f899468d8f041c1e93376755
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spelling	oai:doaj.org-article:7ffd9171f899468d8f041c1e933767552021-12-02T16:14:57ZPractical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution10.1038/s41467-021-24468-z2041-1723https://doaj.org/article/7ffd9171f899468d8f041c1e933767552021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24468-zhttps://doaj.org/toc/2041-17232-(hetero)aryl N-heteroarenes are ubiquitously applied in numerous fields of science and useful for the development of bioactive molecules and drugs, but there is a lack of general methods for their synthesis. Here, the authors report an iridium(III)-catalyzed method for direct α-arylation of N-heteroarenes with aryl and heteroaryl boronic acids, by a H2O-mediated H2-evolution cross-coupling strategy.Liang CaoHe ZhaoRongqing GuanHuanfeng JiangPierre. H. DixneufMin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liang Cao He Zhao Rongqing Guan Huanfeng Jiang Pierre. H. Dixneuf Min Zhang Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution
description	2-(hetero)aryl N-heteroarenes are ubiquitously applied in numerous fields of science and useful for the development of bioactive molecules and drugs, but there is a lack of general methods for their synthesis. Here, the authors report an iridium(III)-catalyzed method for direct α-arylation of N-heteroarenes with aryl and heteroaryl boronic acids, by a H2O-mediated H2-evolution cross-coupling strategy.
format	article
author	Liang Cao He Zhao Rongqing Guan Huanfeng Jiang Pierre. H. Dixneuf Min Zhang
author_facet	Liang Cao He Zhao Rongqing Guan Huanfeng Jiang Pierre. H. Dixneuf Min Zhang
author_sort	Liang Cao
title	Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution
title_short	Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution
title_full	Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution
title_fullStr	Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution
title_full_unstemmed	Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution
title_sort	practical iridium-catalyzed direct α-arylation of n-heteroarenes with (hetero)arylboronic acids by h2o-mediated h2 evolution
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7ffd9171f899468d8f041c1e93376755
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Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution

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