Preparation of nanoparticles of β-cyclodextrin-loaded scutellarein anti-tumor activity research by targeting integrin αvβ3

Abstract Background The problems associated with the poor water solubility of anticancer drugs are one of the most important challenges in achieving effective cancer therapy. The present study was designed to evaluate the effect of scutellarein on human colon cancer cells in vitro by using a target...

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Autores principales:	Jundong Wang, Tianhao Li, Chaochi Yue, Sen Zhong, Xiangdong Yang, Jun Li, Yuanzhi Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Scutellarein Nanoparticles Colon cancer β-Cyclodextrin αvβ3 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7fff91a7e8ee4fc388f0f12e2658176d
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spelling	oai:doaj.org-article:7fff91a7e8ee4fc388f0f12e2658176d2021-11-14T12:11:52ZPreparation of nanoparticles of β-cyclodextrin-loaded scutellarein anti-tumor activity research by targeting integrin αvβ310.1186/s12645-021-00102-x1868-69581868-6966https://doaj.org/article/7fff91a7e8ee4fc388f0f12e2658176d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12645-021-00102-xhttps://doaj.org/toc/1868-6958https://doaj.org/toc/1868-6966Abstract Background The problems associated with the poor water solubility of anticancer drugs are one of the most important challenges in achieving effective cancer therapy. The present study was designed to evaluate the effect of scutellarein on human colon cancer cells in vitro by using a target αvβ3 novel scutellarein (Scu)-loaded niosome nanoparticle (β-CD-CL-Scu-cRGD). Results β-CD-CL-Scu-cRGD has a diameter of 140.2 nm and zeta potential of − 11.3 mV with constant physicochemical stability. The MTT assay showed both Scu and β-CD-CL-Scu-cRGD caused a decrease in cell proliferation and viability of LoVo, but β-CD-CL-Scu-cRGD showed better activity in vitro. Colony formation assay and flow cytometry assay showed that β-CD-CL-Scu-cRGD has a better effect on cell proliferation and apoptosis. In vivo, animal experimental results showed that β-CD-CL-Scu-cRGD can significantly inhibit tumor growth, and the bodyweight of mice decreases during the treatment of scutellarein and its derivatives. β-CD-CL-Scu-cRGD could inhibit the protein levels of Ki67 and αvβ3, thereby inhibiting tumor growth. Conclusions Although further in vitro and in vivo studies are necessary, our results suggested that β-CD-CL-Scu-cRGD could be an outstanding carrier to deliver Scu for potential therapeutic approaches into colon cancer.Jundong WangTianhao LiChaochi YueSen ZhongXiangdong YangJun LiYuanzhi LiBMCarticleScutellareinNanoparticlesColon cancerβ-Cyclodextrinαvβ3Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Nanotechnology, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Scutellarein Nanoparticles Colon cancer β-Cyclodextrin αvβ3 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Scutellarein Nanoparticles Colon cancer β-Cyclodextrin αvβ3 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jundong Wang Tianhao Li Chaochi Yue Sen Zhong Xiangdong Yang Jun Li Yuanzhi Li Preparation of nanoparticles of β-cyclodextrin-loaded scutellarein anti-tumor activity research by targeting integrin αvβ3
description	Abstract Background The problems associated with the poor water solubility of anticancer drugs are one of the most important challenges in achieving effective cancer therapy. The present study was designed to evaluate the effect of scutellarein on human colon cancer cells in vitro by using a target αvβ3 novel scutellarein (Scu)-loaded niosome nanoparticle (β-CD-CL-Scu-cRGD). Results β-CD-CL-Scu-cRGD has a diameter of 140.2 nm and zeta potential of − 11.3 mV with constant physicochemical stability. The MTT assay showed both Scu and β-CD-CL-Scu-cRGD caused a decrease in cell proliferation and viability of LoVo, but β-CD-CL-Scu-cRGD showed better activity in vitro. Colony formation assay and flow cytometry assay showed that β-CD-CL-Scu-cRGD has a better effect on cell proliferation and apoptosis. In vivo, animal experimental results showed that β-CD-CL-Scu-cRGD can significantly inhibit tumor growth, and the bodyweight of mice decreases during the treatment of scutellarein and its derivatives. β-CD-CL-Scu-cRGD could inhibit the protein levels of Ki67 and αvβ3, thereby inhibiting tumor growth. Conclusions Although further in vitro and in vivo studies are necessary, our results suggested that β-CD-CL-Scu-cRGD could be an outstanding carrier to deliver Scu for potential therapeutic approaches into colon cancer.
format	article
author	Jundong Wang Tianhao Li Chaochi Yue Sen Zhong Xiangdong Yang Jun Li Yuanzhi Li
author_facet	Jundong Wang Tianhao Li Chaochi Yue Sen Zhong Xiangdong Yang Jun Li Yuanzhi Li
author_sort	Jundong Wang
title	Preparation of nanoparticles of β-cyclodextrin-loaded scutellarein anti-tumor activity research by targeting integrin αvβ3
title_short	Preparation of nanoparticles of β-cyclodextrin-loaded scutellarein anti-tumor activity research by targeting integrin αvβ3
title_full	Preparation of nanoparticles of β-cyclodextrin-loaded scutellarein anti-tumor activity research by targeting integrin αvβ3
title_fullStr	Preparation of nanoparticles of β-cyclodextrin-loaded scutellarein anti-tumor activity research by targeting integrin αvβ3
title_full_unstemmed	Preparation of nanoparticles of β-cyclodextrin-loaded scutellarein anti-tumor activity research by targeting integrin αvβ3
title_sort	preparation of nanoparticles of β-cyclodextrin-loaded scutellarein anti-tumor activity research by targeting integrin αvβ3
publisher	BMC
publishDate	2021
url	https://doaj.org/article/7fff91a7e8ee4fc388f0f12e2658176d
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_version_	1718429356569657344

Preparation of nanoparticles of β-cyclodextrin-loaded scutellarein anti-tumor activity research by targeting integrin αvβ3

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