Effect of intravitreal dexamethasone solution on the reduction of macular thickness in pseudophakic diabetic patients in a public hospital in Brazil: a randomized clinical trial

Andre Luis A Fonseca, Heitor Panetta, Mauricio A Nascimento, Rodrigo Pessoa C Lira, Carlos Eduardo L ArietaDepartment of Ophthalmology, State University of Campinas, Campinas, São Paulo, BrazilPurpose: To determine the effect of short-term 4 mg/mL dexamethasone solution treatment in diabe...

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Autores principales:	Fonseca ALA, Panetta H, Nascimento MA, Lira RPC, Arieta CEL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	dexamethasone solution short-term treatment diabetic macular edema pseudophakic patients. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/80013f68f9474151855e17ba103e7731
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spelling	oai:doaj.org-article:80013f68f9474151855e17ba103e77312021-12-02T05:44:10ZEffect of intravitreal dexamethasone solution on the reduction of macular thickness in pseudophakic diabetic patients in a public hospital in Brazil: a randomized clinical trial1177-5483https://doaj.org/article/80013f68f9474151855e17ba103e77312019-08-01T00:00:00Zhttps://www.dovepress.com/effect-of-intravitreal-dexamethasone-solution-on-the-reduction-of-macu-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Andre Luis A Fonseca, Heitor Panetta, Mauricio A Nascimento, Rodrigo Pessoa C Lira, Carlos Eduardo L ArietaDepartment of Ophthalmology, State University of Campinas, Campinas, São Paulo, BrazilPurpose: To determine the effect of short-term 4 mg/mL dexamethasone solution treatment in diabetic macular edema (DME).Patients and methods: Twenty-seven pseudophakic diabetic patients with visual impairment caused by DME were randomized to receive 0.01 mL (40 μg), 0.03 mL (120 μg) or 0.05 mL (200 μg) intravitreal dexamethasone solution. Eyes were evaluated in terms of macular thickness, best-corrected visual acuity (BCVA) and intraocular pressure (IOP) at 3, 7 and 28 days after injection (D).Results: There was a significant reduction in macular thickness between D0 and D3 for all groups (0.01 mL – P=0.008, 0.03 mL – P=0.038, and 0.05 mL – P=0.008). Between D0 and D7, a significant reduction in macular thickness was observed in 0.01 mL and 0.05 mL groups (0.01 mL – P=0.013 and 0.05 mL – P=0.021). Between D0 and D28, no significant reduction of macular thickness was observed for any group. Between D0 and D3, a significant improvement in BCVA in the 0.03 mL group (P=0.028) was observed. Between D0 and D7, a significant improvement in BCVA was observed in 0.01 mL and 0.03 mL groups (0.01 mL – P=0.018 and 0.03 mL – P=0.027). Between D0 and D28, a significant improvement in BCVA was observed for the 0.01 mL group (P=0.017). No significant differences in IOP measurements were observed for any group. Safety analysis revealed no serious ocular or systemic events.Conclusion and relevance: Intravitreal dexamethasone solution is effective in reducing macular thickness secondary to DME in the short-term. Improvement in short-term visual acuity was observed. Although DME requires long-term treatment, it may be a low cost therapeutic option used in specific short-term situations.Trial registration: NCT03608839 (http://www.clinicaltrials.gov).Keywords: intravitreal dexamethasone solution, short-term treatment, diabetic macular edema, pseudophakic patientsFonseca ALAPanetta HNascimento MALira RPCArieta CELDove Medical Pressarticledexamethasone solutionshort-term treatmentdiabetic macular edemapseudophakic patients.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1523-1531 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	dexamethasone solution short-term treatment diabetic macular edema pseudophakic patients. Ophthalmology RE1-994
spellingShingle	dexamethasone solution short-term treatment diabetic macular edema pseudophakic patients. Ophthalmology RE1-994 Fonseca ALA Panetta H Nascimento MA Lira RPC Arieta CEL Effect of intravitreal dexamethasone solution on the reduction of macular thickness in pseudophakic diabetic patients in a public hospital in Brazil: a randomized clinical trial
description	Andre Luis A Fonseca, Heitor Panetta, Mauricio A Nascimento, Rodrigo Pessoa C Lira, Carlos Eduardo L ArietaDepartment of Ophthalmology, State University of Campinas, Campinas, São Paulo, BrazilPurpose: To determine the effect of short-term 4 mg/mL dexamethasone solution treatment in diabetic macular edema (DME).Patients and methods: Twenty-seven pseudophakic diabetic patients with visual impairment caused by DME were randomized to receive 0.01 mL (40 μg), 0.03 mL (120 μg) or 0.05 mL (200 μg) intravitreal dexamethasone solution. Eyes were evaluated in terms of macular thickness, best-corrected visual acuity (BCVA) and intraocular pressure (IOP) at 3, 7 and 28 days after injection (D).Results: There was a significant reduction in macular thickness between D0 and D3 for all groups (0.01 mL – P=0.008, 0.03 mL – P=0.038, and 0.05 mL – P=0.008). Between D0 and D7, a significant reduction in macular thickness was observed in 0.01 mL and 0.05 mL groups (0.01 mL – P=0.013 and 0.05 mL – P=0.021). Between D0 and D28, no significant reduction of macular thickness was observed for any group. Between D0 and D3, a significant improvement in BCVA in the 0.03 mL group (P=0.028) was observed. Between D0 and D7, a significant improvement in BCVA was observed in 0.01 mL and 0.03 mL groups (0.01 mL – P=0.018 and 0.03 mL – P=0.027). Between D0 and D28, a significant improvement in BCVA was observed for the 0.01 mL group (P=0.017). No significant differences in IOP measurements were observed for any group. Safety analysis revealed no serious ocular or systemic events.Conclusion and relevance: Intravitreal dexamethasone solution is effective in reducing macular thickness secondary to DME in the short-term. Improvement in short-term visual acuity was observed. Although DME requires long-term treatment, it may be a low cost therapeutic option used in specific short-term situations.Trial registration: NCT03608839 (http://www.clinicaltrials.gov).Keywords: intravitreal dexamethasone solution, short-term treatment, diabetic macular edema, pseudophakic patients
format	article
author	Fonseca ALA Panetta H Nascimento MA Lira RPC Arieta CEL
author_facet	Fonseca ALA Panetta H Nascimento MA Lira RPC Arieta CEL
author_sort	Fonseca ALA
title	Effect of intravitreal dexamethasone solution on the reduction of macular thickness in pseudophakic diabetic patients in a public hospital in Brazil: a randomized clinical trial
title_short	Effect of intravitreal dexamethasone solution on the reduction of macular thickness in pseudophakic diabetic patients in a public hospital in Brazil: a randomized clinical trial
title_full	Effect of intravitreal dexamethasone solution on the reduction of macular thickness in pseudophakic diabetic patients in a public hospital in Brazil: a randomized clinical trial
title_fullStr	Effect of intravitreal dexamethasone solution on the reduction of macular thickness in pseudophakic diabetic patients in a public hospital in Brazil: a randomized clinical trial
title_full_unstemmed	Effect of intravitreal dexamethasone solution on the reduction of macular thickness in pseudophakic diabetic patients in a public hospital in Brazil: a randomized clinical trial
title_sort	effect of intravitreal dexamethasone solution on the reduction of macular thickness in pseudophakic diabetic patients in a public hospital in brazil: a randomized clinical trial
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/80013f68f9474151855e17ba103e7731
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Effect of intravitreal dexamethasone solution on the reduction of macular thickness in pseudophakic diabetic patients in a public hospital in Brazil: a randomized clinical trial

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