Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation

Some anesthetics despite being generally associated with sedation, can also increase brain activity—a phenomenon called paradoxical excitation. The authors identified dozens of compounds that generally decrease neuronal activity, but increase activity in the caudal hindbrain of zebrafish.

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Autores principales:	Matthew N. McCarroll, Leo Gendelev, Reid Kinser, Jack Taylor, Giancarlo Bruni, Douglas Myers-Turnbull, Cole Helsell, Amanda Carbajal, Capria Rinaldi, Hye Jin Kang, Jung Ho Gong, Jason K. Sello, Susumu Tomita, Randall T. Peterson, Michael J. Keiser, David Kokel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/800557a8a9ec49a7a80e98ddf53a8be2
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spelling	oai:doaj.org-article:800557a8a9ec49a7a80e98ddf53a8be22021-12-02T17:02:15ZZebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation10.1038/s41467-019-11936-w2041-1723https://doaj.org/article/800557a8a9ec49a7a80e98ddf53a8be22019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11936-whttps://doaj.org/toc/2041-1723Some anesthetics despite being generally associated with sedation, can also increase brain activity—a phenomenon called paradoxical excitation. The authors identified dozens of compounds that generally decrease neuronal activity, but increase activity in the caudal hindbrain of zebrafish.Matthew N. McCarrollLeo GendelevReid KinserJack TaylorGiancarlo BruniDouglas Myers-TurnbullCole HelsellAmanda CarbajalCapria RinaldiHye Jin KangJung Ho GongJason K. SelloSusumu TomitaRandall T. PetersonMichael J. KeiserDavid KokelNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew N. McCarroll Leo Gendelev Reid Kinser Jack Taylor Giancarlo Bruni Douglas Myers-Turnbull Cole Helsell Amanda Carbajal Capria Rinaldi Hye Jin Kang Jung Ho Gong Jason K. Sello Susumu Tomita Randall T. Peterson Michael J. Keiser David Kokel Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
description	Some anesthetics despite being generally associated with sedation, can also increase brain activity—a phenomenon called paradoxical excitation. The authors identified dozens of compounds that generally decrease neuronal activity, but increase activity in the caudal hindbrain of zebrafish.
format	article
author	Matthew N. McCarroll Leo Gendelev Reid Kinser Jack Taylor Giancarlo Bruni Douglas Myers-Turnbull Cole Helsell Amanda Carbajal Capria Rinaldi Hye Jin Kang Jung Ho Gong Jason K. Sello Susumu Tomita Randall T. Peterson Michael J. Keiser David Kokel
author_facet	Matthew N. McCarroll Leo Gendelev Reid Kinser Jack Taylor Giancarlo Bruni Douglas Myers-Turnbull Cole Helsell Amanda Carbajal Capria Rinaldi Hye Jin Kang Jung Ho Gong Jason K. Sello Susumu Tomita Randall T. Peterson Michael J. Keiser David Kokel
author_sort	Matthew N. McCarroll
title	Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
title_short	Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
title_full	Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
title_fullStr	Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
title_full_unstemmed	Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
title_sort	zebrafish behavioural profiling identifies gaba and serotonin receptor ligands related to sedation and paradoxical excitation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/800557a8a9ec49a7a80e98ddf53a8be2
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Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation

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