Digitalizing the Microbiome for Human Health

ABSTRACT The microbiome has recently joined the club of endocrine entities of the human body that are involved in homeostasis and disease. Microbiome characterizations are now typically included in longitudinal and cross-sectional population studies, associations with microbiome features have been m...

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Autores principales:	Kirti Nath, Christoph A. Thaiss
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	MWAS artificial intelligence disease health microbiome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/80072911a4c84239ae46d78545a41769
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spelling	oai:doaj.org-article:80072911a4c84239ae46d78545a417692021-12-02T19:46:18ZDigitalizing the Microbiome for Human Health10.1128/mSystems.00129-192379-5077https://doaj.org/article/80072911a4c84239ae46d78545a417692019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00129-19https://doaj.org/toc/2379-5077ABSTRACT The microbiome has recently joined the club of endocrine entities of the human body that are involved in homeostasis and disease. Microbiome characterizations are now typically included in longitudinal and cross-sectional population studies, associations with microbiome features have been made for almost any human disease, and the molecules by which the microbiome functionally contributes to host physiology are being elucidated. The leverage of these efforts for human health, however, is still rather modest. In this Perspective, we summarize some of the challenges that need to be overcome in order to make microbiome studies as informative for human health as genetic studies. Focusing on the role of the microbiome in host metabolism and inflammation, we also outline potential strategies that can be employed to achieve the next milestones in the journey toward microbiome-informed human health assessment and action.Kirti NathChristoph A. ThaissAmerican Society for MicrobiologyarticleMWASartificial intelligencediseasehealthmicrobiomeMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	MWAS artificial intelligence disease health microbiome Microbiology QR1-502
spellingShingle	MWAS artificial intelligence disease health microbiome Microbiology QR1-502 Kirti Nath Christoph A. Thaiss Digitalizing the Microbiome for Human Health
description	ABSTRACT The microbiome has recently joined the club of endocrine entities of the human body that are involved in homeostasis and disease. Microbiome characterizations are now typically included in longitudinal and cross-sectional population studies, associations with microbiome features have been made for almost any human disease, and the molecules by which the microbiome functionally contributes to host physiology are being elucidated. The leverage of these efforts for human health, however, is still rather modest. In this Perspective, we summarize some of the challenges that need to be overcome in order to make microbiome studies as informative for human health as genetic studies. Focusing on the role of the microbiome in host metabolism and inflammation, we also outline potential strategies that can be employed to achieve the next milestones in the journey toward microbiome-informed human health assessment and action.
format	article
author	Kirti Nath Christoph A. Thaiss
author_facet	Kirti Nath Christoph A. Thaiss
author_sort	Kirti Nath
title	Digitalizing the Microbiome for Human Health
title_short	Digitalizing the Microbiome for Human Health
title_full	Digitalizing the Microbiome for Human Health
title_fullStr	Digitalizing the Microbiome for Human Health
title_full_unstemmed	Digitalizing the Microbiome for Human Health
title_sort	digitalizing the microbiome for human health
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/80072911a4c84239ae46d78545a41769
work_keys_str_mv	AT kirtinath digitalizingthemicrobiomeforhumanhealth AT christophathaiss digitalizingthemicrobiomeforhumanhealth
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Digitalizing the Microbiome for Human Health

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