Adult human mesenchymal stromal cells and the treatment of graft versus host disease

Richard P Herrmann, Marian J Sturm Cell and Tissue Therapies, Western Australia, Royal Perth Hospital, Wellington Street, Perth, WA, Australia Abstract: Graft versus host disease is a difficult and potentially lethal complication of hematopoietic stem cell transplantation. It occurs with minor hum...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Herrmann RP, Sturm MJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/8009406fc0f44d53917fb549c9e75609
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8009406fc0f44d53917fb549c9e75609
record_format	dspace
spelling	oai:doaj.org-article:8009406fc0f44d53917fb549c9e756092021-12-02T03:36:18ZAdult human mesenchymal stromal cells and the treatment of graft versus host disease1178-6957https://doaj.org/article/8009406fc0f44d53917fb549c9e756092014-02-01T00:00:00Zhttp://www.dovepress.com/adult-human-mesenchymal-stromal-cells-and-the-treatment-of-graft-versu-a15988https://doaj.org/toc/1178-6957 Richard P Herrmann, Marian J Sturm Cell and Tissue Therapies, Western Australia, Royal Perth Hospital, Wellington Street, Perth, WA, Australia Abstract: Graft versus host disease is a difficult and potentially lethal complication of hematopoietic stem cell transplantation. It occurs with minor human leucocyte antigen (HLA) mismatch and is normally treated with corticosteroid and other immunosuppressive therapy. When it is refractory to steroid therapy, mortality approaches 80%. Mesenchymal stromal cells are rare cells found in bone marrow and other tissues. They can be expanded in culture and possess complex and diverse immunomodulatory activity. Moreover, human mesenchymal stromal cells carry low levels of class 1 and no class 2 HLA antigens, making them immunoprivileged and able to be used without HLA matching. Their use in steroid-refractory graft versus host disease was first described in 2004. Subsequently, they have been used in a number of Phase I and II trials in acute and chronic graft versus host disease trials with success. We discuss their mode of action, the results, their production, and potential dangers with a view to future application. Keywords: mesenchymal stromal cells, graft versus host disease, acute, chronicHerrmann RPSturm MJDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2014, Iss default, Pp 45-52 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Herrmann RP Sturm MJ Adult human mesenchymal stromal cells and the treatment of graft versus host disease
description	Richard P Herrmann, Marian J Sturm Cell and Tissue Therapies, Western Australia, Royal Perth Hospital, Wellington Street, Perth, WA, Australia Abstract: Graft versus host disease is a difficult and potentially lethal complication of hematopoietic stem cell transplantation. It occurs with minor human leucocyte antigen (HLA) mismatch and is normally treated with corticosteroid and other immunosuppressive therapy. When it is refractory to steroid therapy, mortality approaches 80%. Mesenchymal stromal cells are rare cells found in bone marrow and other tissues. They can be expanded in culture and possess complex and diverse immunomodulatory activity. Moreover, human mesenchymal stromal cells carry low levels of class 1 and no class 2 HLA antigens, making them immunoprivileged and able to be used without HLA matching. Their use in steroid-refractory graft versus host disease was first described in 2004. Subsequently, they have been used in a number of Phase I and II trials in acute and chronic graft versus host disease trials with success. We discuss their mode of action, the results, their production, and potential dangers with a view to future application. Keywords: mesenchymal stromal cells, graft versus host disease, acute, chronic
format	article
author	Herrmann RP Sturm MJ
author_facet	Herrmann RP Sturm MJ
author_sort	Herrmann RP
title	Adult human mesenchymal stromal cells and the treatment of graft versus host disease
title_short	Adult human mesenchymal stromal cells and the treatment of graft versus host disease
title_full	Adult human mesenchymal stromal cells and the treatment of graft versus host disease
title_fullStr	Adult human mesenchymal stromal cells and the treatment of graft versus host disease
title_full_unstemmed	Adult human mesenchymal stromal cells and the treatment of graft versus host disease
title_sort	adult human mesenchymal stromal cells and the treatment of graft versus host disease
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/8009406fc0f44d53917fb549c9e75609
work_keys_str_mv	AT herrmannrp adulthumanmesenchymalstromalcellsandthetreatmentofgraftversushostdisease AT sturmmj adulthumanmesenchymalstromalcellsandthetreatmentofgraftversushostdisease
_version_	1718401675234902016

Adult human mesenchymal stromal cells and the treatment of graft versus host disease

Ejemplares similares