Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer

Abstract There are a few biological functions or phenomenon which are universally associated with majority of the cancers and hypoxia and immune systems are among them. Hypoxia often occurs in most of the cancers which helps the cells in adapting different responses with respect to the normal cells...

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Autores principales:	Leena Hussein Bajrai, Sayed Sartaj Sohrab, Mohammad Mobashir, Mohammad Amjad Kamal, Moshahid Alam Rizvi, Esam Ibraheem Azhar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/800b5d5b62174f2386288a8c69de048c
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spelling	oai:doaj.org-article:800b5d5b62174f2386288a8c69de048c2021-12-02T17:37:34ZUnderstanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer10.1038/s41598-021-98031-72045-2322https://doaj.org/article/800b5d5b62174f2386288a8c69de048c2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98031-7https://doaj.org/toc/2045-2322Abstract There are a few biological functions or phenomenon which are universally associated with majority of the cancers and hypoxia and immune systems are among them. Hypoxia often occurs in most of the cancers which helps the cells in adapting different responses with respect to the normal cells which may be the activation of signaling pathways which regulate proliferation, angiogenesis, and cell death. Similar to it, immune signaling pathways are known to play critical roles in cancers. Moreover, there are a number of genes which are known to be associated with these hypoxia and immune system and appear to direct affect the tumor growth and propagations. Cancer is among the leading cause of death and oral cancer is the tenth-leading cause due to cancer death. In this study, we were mainly interested to understand the impact of alteration in the expression of hypoxia and immune system-related genes and their contribution to head and neck squamous cell carcinoma. Moreover, we have collected the genes associated with hypoxia and immune system from the literatures. In this work, we have performed meta-analysis of the gene and microRNA expression and mutational datasets obtained from public database for different grades of tumor in case of oral cancer. Based on our results, we conclude that the critical pathways which dominantly enriched are associated with metabolism, cell cycle, immune system and based on the survival analysis of the hypoxic genes, we observe that the potential genes associated with head and neck squamous cell carcinoma and its progression are STC2, PGK1, P4HA1, HK1, SPIB, ANXA5, SERPINE1, HGF, PFKM, TGFB1, L1CAM, ELK4, EHF, and CDK2.Leena Hussein BajraiSayed Sartaj SohrabMohammad MobashirMohammad Amjad KamalMoshahid Alam RizviEsam Ibraheem AzharNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leena Hussein Bajrai Sayed Sartaj Sohrab Mohammad Mobashir Mohammad Amjad Kamal Moshahid Alam Rizvi Esam Ibraheem Azhar Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer
description	Abstract There are a few biological functions or phenomenon which are universally associated with majority of the cancers and hypoxia and immune systems are among them. Hypoxia often occurs in most of the cancers which helps the cells in adapting different responses with respect to the normal cells which may be the activation of signaling pathways which regulate proliferation, angiogenesis, and cell death. Similar to it, immune signaling pathways are known to play critical roles in cancers. Moreover, there are a number of genes which are known to be associated with these hypoxia and immune system and appear to direct affect the tumor growth and propagations. Cancer is among the leading cause of death and oral cancer is the tenth-leading cause due to cancer death. In this study, we were mainly interested to understand the impact of alteration in the expression of hypoxia and immune system-related genes and their contribution to head and neck squamous cell carcinoma. Moreover, we have collected the genes associated with hypoxia and immune system from the literatures. In this work, we have performed meta-analysis of the gene and microRNA expression and mutational datasets obtained from public database for different grades of tumor in case of oral cancer. Based on our results, we conclude that the critical pathways which dominantly enriched are associated with metabolism, cell cycle, immune system and based on the survival analysis of the hypoxic genes, we observe that the potential genes associated with head and neck squamous cell carcinoma and its progression are STC2, PGK1, P4HA1, HK1, SPIB, ANXA5, SERPINE1, HGF, PFKM, TGFB1, L1CAM, ELK4, EHF, and CDK2.
format	article
author	Leena Hussein Bajrai Sayed Sartaj Sohrab Mohammad Mobashir Mohammad Amjad Kamal Moshahid Alam Rizvi Esam Ibraheem Azhar
author_facet	Leena Hussein Bajrai Sayed Sartaj Sohrab Mohammad Mobashir Mohammad Amjad Kamal Moshahid Alam Rizvi Esam Ibraheem Azhar
author_sort	Leena Hussein Bajrai
title	Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer
title_short	Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer
title_full	Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer
title_fullStr	Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer
title_full_unstemmed	Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer
title_sort	understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/800b5d5b62174f2386288a8c69de048c
work_keys_str_mv	AT leenahusseinbajrai understandingtheroleofpotentialpathwaysanditscomponentsincludinghypoxiaandimmunesystemincaseoforalcancer AT sayedsartajsohrab understandingtheroleofpotentialpathwaysanditscomponentsincludinghypoxiaandimmunesystemincaseoforalcancer AT mohammadmobashir understandingtheroleofpotentialpathwaysanditscomponentsincludinghypoxiaandimmunesystemincaseoforalcancer AT mohammadamjadkamal understandingtheroleofpotentialpathwaysanditscomponentsincludinghypoxiaandimmunesystemincaseoforalcancer AT moshahidalamrizvi understandingtheroleofpotentialpathwaysanditscomponentsincludinghypoxiaandimmunesystemincaseoforalcancer AT esamibraheemazhar understandingtheroleofpotentialpathwaysanditscomponentsincludinghypoxiaandimmunesystemincaseoforalcancer
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Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer

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