Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia

Debilitating anemias in chronic diseases can result from deficient iron delivery to red cell precursors. Here, the authors show how this deficiency damages the cytoskeletal framework of progenitor cells and identify a targeted strategy for cytoskeletal repair, leading to anemia correction.

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Autores principales:	Adam N. Goldfarb, Katie C. Freeman, Ranjit K. Sahu, Kamaleldin E. Elagib, Maja Holy, Abhinav Arneja, Renata Polanowska-Grabowska, Alejandro A. Gru, Zollie White, Shadi Khalil, Michael J. Kerins, Aikseng Ooi, Norbert Leitinger, Chance John Luckey, Lorrie L. Delehanty
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/800cc6d5dbd045848f159db5971f182f
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spelling	oai:doaj.org-article:800cc6d5dbd045848f159db5971f182f2021-12-02T13:31:14ZIron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia10.1038/s41467-021-21938-22041-1723https://doaj.org/article/800cc6d5dbd045848f159db5971f182f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21938-2https://doaj.org/toc/2041-1723Debilitating anemias in chronic diseases can result from deficient iron delivery to red cell precursors. Here, the authors show how this deficiency damages the cytoskeletal framework of progenitor cells and identify a targeted strategy for cytoskeletal repair, leading to anemia correction.Adam N. GoldfarbKatie C. FreemanRanjit K. SahuKamaleldin E. ElagibMaja HolyAbhinav ArnejaRenata Polanowska-GrabowskaAlejandro A. GruZollie WhiteShadi KhalilMichael J. KerinsAikseng OoiNorbert LeitingerChance John LuckeyLorrie L. DelehantyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adam N. Goldfarb Katie C. Freeman Ranjit K. Sahu Kamaleldin E. Elagib Maja Holy Abhinav Arneja Renata Polanowska-Grabowska Alejandro A. Gru Zollie White Shadi Khalil Michael J. Kerins Aikseng Ooi Norbert Leitinger Chance John Luckey Lorrie L. Delehanty Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia
description	Debilitating anemias in chronic diseases can result from deficient iron delivery to red cell precursors. Here, the authors show how this deficiency damages the cytoskeletal framework of progenitor cells and identify a targeted strategy for cytoskeletal repair, leading to anemia correction.
format	article
author	Adam N. Goldfarb Katie C. Freeman Ranjit K. Sahu Kamaleldin E. Elagib Maja Holy Abhinav Arneja Renata Polanowska-Grabowska Alejandro A. Gru Zollie White Shadi Khalil Michael J. Kerins Aikseng Ooi Norbert Leitinger Chance John Luckey Lorrie L. Delehanty
author_facet	Adam N. Goldfarb Katie C. Freeman Ranjit K. Sahu Kamaleldin E. Elagib Maja Holy Abhinav Arneja Renata Polanowska-Grabowska Alejandro A. Gru Zollie White Shadi Khalil Michael J. Kerins Aikseng Ooi Norbert Leitinger Chance John Luckey Lorrie L. Delehanty
author_sort	Adam N. Goldfarb
title	Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia
title_short	Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia
title_full	Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia
title_fullStr	Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia
title_full_unstemmed	Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia
title_sort	iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/800cc6d5dbd045848f159db5971f182f
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Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia

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