Dietary soy, pork and chicken proteins induce distinct nitrogen metabolism in rat liver

Diets have been shown to alter metabolism and gene expression. However, few data are available about changes in gene expression in liver after intake of different meat protein diets. This work aimed to explore the long-term effects of protein source on liver metabolic enzymes. Rats were fed protein...

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Auteurs principaux:	Zixin Huang, Xuebin Shi, Guanghong Zhou, Chunbao Li
Format:	article
Langue:	EN
Publié:	Elsevier 2021
Sujets:	Dietary protein Proteome Rat liver Amino acid Nitrogen metabolism Nutrition. Foods and food supply TX341-641
Accès en ligne:	https://doaj.org/article/800e1b4a52aa4a54b28be583fd06d3e2
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spelling	oai:doaj.org-article:800e1b4a52aa4a54b28be583fd06d3e22021-11-12T04:48:30ZDietary soy, pork and chicken proteins induce distinct nitrogen metabolism in rat liver2666-566210.1016/j.fochms.2021.100050https://doaj.org/article/800e1b4a52aa4a54b28be583fd06d3e22021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666566221000411https://doaj.org/toc/2666-5662Diets have been shown to alter metabolism and gene expression. However, few data are available about changes in gene expression in liver after intake of different meat protein diets. This work aimed to explore the long-term effects of protein source on liver metabolic enzymes. Rats were fed protein diets for 90 days to study whether intake of chicken and pork protein diets promoted gene expression involved in hepatic metabolism. Liver proteome profiles were measured by iTRAQ labeling and LC–ESI–MS/MS. Chicken protein diet induced higher level of serum amino acids in rats than soy protein. Amino acid metabolizing enzymes were downregulated by pork and chicken protein diets compared with soy protein diet. Intake of meat protein diets downregulated enzymes involved in protein synthesis, disulfide bond formation, signal peptide addition, transport, localization, degradation and glycosylation modification, but upregulated enzymes involved in prolyl cis–trans isomerization for protein synthesis. Protein diets from different sources affected the amino acid supply, and further influenced ribosome assembly and protein synthesis through mTOR signaling pathway.Zixin HuangXuebin ShiGuanghong ZhouChunbao LiElsevierarticleDietary proteinProteomeRat liverAmino acidNitrogen metabolismNutrition. Foods and food supplyTX341-641ENFood Chemistry: Molecular Sciences, Vol 3, Iss , Pp 100050- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dietary protein Proteome Rat liver Amino acid Nitrogen metabolism Nutrition. Foods and food supply TX341-641
spellingShingle	Dietary protein Proteome Rat liver Amino acid Nitrogen metabolism Nutrition. Foods and food supply TX341-641 Zixin Huang Xuebin Shi Guanghong Zhou Chunbao Li Dietary soy, pork and chicken proteins induce distinct nitrogen metabolism in rat liver
description	Diets have been shown to alter metabolism and gene expression. However, few data are available about changes in gene expression in liver after intake of different meat protein diets. This work aimed to explore the long-term effects of protein source on liver metabolic enzymes. Rats were fed protein diets for 90 days to study whether intake of chicken and pork protein diets promoted gene expression involved in hepatic metabolism. Liver proteome profiles were measured by iTRAQ labeling and LC–ESI–MS/MS. Chicken protein diet induced higher level of serum amino acids in rats than soy protein. Amino acid metabolizing enzymes were downregulated by pork and chicken protein diets compared with soy protein diet. Intake of meat protein diets downregulated enzymes involved in protein synthesis, disulfide bond formation, signal peptide addition, transport, localization, degradation and glycosylation modification, but upregulated enzymes involved in prolyl cis–trans isomerization for protein synthesis. Protein diets from different sources affected the amino acid supply, and further influenced ribosome assembly and protein synthesis through mTOR signaling pathway.
format	article
author	Zixin Huang Xuebin Shi Guanghong Zhou Chunbao Li
author_facet	Zixin Huang Xuebin Shi Guanghong Zhou Chunbao Li
author_sort	Zixin Huang
title	Dietary soy, pork and chicken proteins induce distinct nitrogen metabolism in rat liver
title_short	Dietary soy, pork and chicken proteins induce distinct nitrogen metabolism in rat liver
title_full	Dietary soy, pork and chicken proteins induce distinct nitrogen metabolism in rat liver
title_fullStr	Dietary soy, pork and chicken proteins induce distinct nitrogen metabolism in rat liver
title_full_unstemmed	Dietary soy, pork and chicken proteins induce distinct nitrogen metabolism in rat liver
title_sort	dietary soy, pork and chicken proteins induce distinct nitrogen metabolism in rat liver
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/800e1b4a52aa4a54b28be583fd06d3e2
work_keys_str_mv	AT zixinhuang dietarysoyporkandchickenproteinsinducedistinctnitrogenmetabolisminratliver AT xuebinshi dietarysoyporkandchickenproteinsinducedistinctnitrogenmetabolisminratliver AT guanghongzhou dietarysoyporkandchickenproteinsinducedistinctnitrogenmetabolisminratliver AT chunbaoli dietarysoyporkandchickenproteinsinducedistinctnitrogenmetabolisminratliver
_version_	1718431239040401408

Dietary soy, pork and chicken proteins induce distinct nitrogen metabolism in rat liver

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