Subcutaneous interferon β-1a may protect against cognitive impairment in patients with relapsing-remitting multiple sclerosis: 5-year follow-up of the COGIMUS study.

<h4>Objective</h4>To assess the effects of subcutaneous (sc) interferon (IFN) -1a on cognition over 5 years in mildly disabled patients with relapsing-remitting multiple sclerosis (RRMS).<h4>Methods</h4>Patients aged 18-50 years with RRMS (Expanded Disability Status Scale sco...

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Autores principales: Francesco Patti, Vincenzo Brescia Morra, Maria Pia Amato, Maria Trojano, Stefano Bastianello, Maria Rosalia Tola, Salvatore Cottone, Andrea Plant, Orietta Picconi, COGIMUS Study Group
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Publicado: Public Library of Science (PLoS) 2013
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spelling oai:doaj.org-article:800e43a06cb94062af19133380974aa32021-11-18T08:57:30ZSubcutaneous interferon β-1a may protect against cognitive impairment in patients with relapsing-remitting multiple sclerosis: 5-year follow-up of the COGIMUS study.1932-620310.1371/journal.pone.0074111https://doaj.org/article/800e43a06cb94062af19133380974aa32013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24137499/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To assess the effects of subcutaneous (sc) interferon (IFN) -1a on cognition over 5 years in mildly disabled patients with relapsing-remitting multiple sclerosis (RRMS).<h4>Methods</h4>Patients aged 18-50 years with RRMS (Expanded Disability Status Scale score ≤4.0) who had completed the 3-year COGIMUS study underwent standardized magnetic resonance imaging, neurological examination, and neuropsychological testing at years 4 and 5. Predictors of cognitive impairment at year 5 were identified using multivariate analysis.<h4>Results</h4>Of 331 patients who completed the 3-year COGIMUS study, 265 participated in the 2-year extension study, 201 of whom (75.8%; sc IFN β-1a three times weekly: 44 µg, n = 108; 22 µg, n = 93) completed 5 years' follow-up. The proportion of patients with cognitive impairment in the study population overall remained stable between baseline (18.0%) and year 5 (22.6%). The proportion of patients with cognitive impairment also remained stable in both treatment groups between baseline and year 5, and between year 3 and year 5. However, a significantly higher proportion of men than women had cognitive impairment at year 5 (26.5% vs 14.4%, p = 0.046). Treatment with the 22 versus 44 µg dose was predictive of cognitive impairment at year 5 (hazard ratio 0.68; 95% confidence interval 0.48-0.97).<h4>Conclusions</h4>This study suggests that sc IFN β-1a dose-dependently stabilizes or delays cognitive impairment over a 5-year period in most patients with mild RRMS. Women seem to be more protected against developing cognitive impairment, which may indicate greater response to therapy or the inherently better prognosis associated with female sex in MS.Francesco PattiVincenzo Brescia MorraMaria Pia AmatoMaria TrojanoStefano BastianelloMaria Rosalia TolaSalvatore CottoneAndrea PlantOrietta PicconiCOGIMUS Study GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e74111 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Francesco Patti
Vincenzo Brescia Morra
Maria Pia Amato
Maria Trojano
Stefano Bastianello
Maria Rosalia Tola
Salvatore Cottone
Andrea Plant
Orietta Picconi
COGIMUS Study Group
Subcutaneous interferon β-1a may protect against cognitive impairment in patients with relapsing-remitting multiple sclerosis: 5-year follow-up of the COGIMUS study.
description <h4>Objective</h4>To assess the effects of subcutaneous (sc) interferon (IFN) -1a on cognition over 5 years in mildly disabled patients with relapsing-remitting multiple sclerosis (RRMS).<h4>Methods</h4>Patients aged 18-50 years with RRMS (Expanded Disability Status Scale score ≤4.0) who had completed the 3-year COGIMUS study underwent standardized magnetic resonance imaging, neurological examination, and neuropsychological testing at years 4 and 5. Predictors of cognitive impairment at year 5 were identified using multivariate analysis.<h4>Results</h4>Of 331 patients who completed the 3-year COGIMUS study, 265 participated in the 2-year extension study, 201 of whom (75.8%; sc IFN β-1a three times weekly: 44 µg, n = 108; 22 µg, n = 93) completed 5 years' follow-up. The proportion of patients with cognitive impairment in the study population overall remained stable between baseline (18.0%) and year 5 (22.6%). The proportion of patients with cognitive impairment also remained stable in both treatment groups between baseline and year 5, and between year 3 and year 5. However, a significantly higher proportion of men than women had cognitive impairment at year 5 (26.5% vs 14.4%, p = 0.046). Treatment with the 22 versus 44 µg dose was predictive of cognitive impairment at year 5 (hazard ratio 0.68; 95% confidence interval 0.48-0.97).<h4>Conclusions</h4>This study suggests that sc IFN β-1a dose-dependently stabilizes or delays cognitive impairment over a 5-year period in most patients with mild RRMS. Women seem to be more protected against developing cognitive impairment, which may indicate greater response to therapy or the inherently better prognosis associated with female sex in MS.
format article
author Francesco Patti
Vincenzo Brescia Morra
Maria Pia Amato
Maria Trojano
Stefano Bastianello
Maria Rosalia Tola
Salvatore Cottone
Andrea Plant
Orietta Picconi
COGIMUS Study Group
author_facet Francesco Patti
Vincenzo Brescia Morra
Maria Pia Amato
Maria Trojano
Stefano Bastianello
Maria Rosalia Tola
Salvatore Cottone
Andrea Plant
Orietta Picconi
COGIMUS Study Group
author_sort Francesco Patti
title Subcutaneous interferon β-1a may protect against cognitive impairment in patients with relapsing-remitting multiple sclerosis: 5-year follow-up of the COGIMUS study.
title_short Subcutaneous interferon β-1a may protect against cognitive impairment in patients with relapsing-remitting multiple sclerosis: 5-year follow-up of the COGIMUS study.
title_full Subcutaneous interferon β-1a may protect against cognitive impairment in patients with relapsing-remitting multiple sclerosis: 5-year follow-up of the COGIMUS study.
title_fullStr Subcutaneous interferon β-1a may protect against cognitive impairment in patients with relapsing-remitting multiple sclerosis: 5-year follow-up of the COGIMUS study.
title_full_unstemmed Subcutaneous interferon β-1a may protect against cognitive impairment in patients with relapsing-remitting multiple sclerosis: 5-year follow-up of the COGIMUS study.
title_sort subcutaneous interferon β-1a may protect against cognitive impairment in patients with relapsing-remitting multiple sclerosis: 5-year follow-up of the cogimus study.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/800e43a06cb94062af19133380974aa3
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