HPV Prevalence and Genotype Distribution Among Women From Hengyang District of Hunan Province, China

Most cervical cancers were closely associated with human papillomavirus (HPV) infections. Therefore, understanding the ecological diversity of HPV prevalence and genotype distribution among various populations in different geographical regions was essential for optimizing HPV vaccination and maximiz...

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Autores principales:	Shuang-yang Tang, Ya-qi Liao, Yu Hu, Hai-yan Shen, Yan-ping Wan, Yi-mou Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	human papillomavirus prevalence genotype distribution cervical cancer Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/80122c4e27f54c52aabced9e367d21fd
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spelling	oai:doaj.org-article:80122c4e27f54c52aabced9e367d21fd2021-11-05T07:13:36ZHPV Prevalence and Genotype Distribution Among Women From Hengyang District of Hunan Province, China2296-256510.3389/fpubh.2021.710209https://doaj.org/article/80122c4e27f54c52aabced9e367d21fd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.710209/fullhttps://doaj.org/toc/2296-2565Most cervical cancers were closely associated with human papillomavirus (HPV) infections. Therefore, understanding the ecological diversity of HPV prevalence and genotype distribution among various populations in different geographical regions was essential for optimizing HPV vaccination and maximizing the vaccination effects. A total of 12,053 patient data from the three-level hospitals in Hengyang city were retrospectively analyzed. In this study, the HPV prevalence was 10.16% overall, and the multiple-type infection rate was 1.83%. The HR-HPV infection rate was 8.52%. The top six HPV genotypes were as follows in descending order: HPV16, HPV58, HPV52, HPV39, HPV51, and HPV53. The HPV prevalence in the group above 60 years old was the most, and their HR-HPV infection rate corresponded to the most too. The infection rates of HPV and HR-HPV among outpatients were both lower than those among the hospitalized-patients, respectively. Among the hospitalized-patients, the infection rates of HPV and HR-HPV among the 50–60 years group were the most in both. The HR-HPV ratio-in-positive among HPV-positive patients with the histopathologic examination was higher than that among those patients without. Among 52 HPV-positive patients with cervical squamous carcinoma, the ratio-in-positive of HPV16 was 61.54%. This study demonstrated that the HPV prevalence varied with age among women from Hengyang district of Hunan province in China and showed that HPV16, HPV58, HPV52, HPV39, HPV51, and HPV53 genotypes were more popularly distributed in this region, which could provide the experimental basis for Chinese public health measures on cervical cancer prevention.Shuang-yang TangYa-qi LiaoYu HuHai-yan ShenYan-ping WanYi-mou WuFrontiers Media S.A.articlehuman papillomavirusprevalencegenotypedistributioncervical cancerPublic aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human papillomavirus prevalence genotype distribution cervical cancer Public aspects of medicine RA1-1270
spellingShingle	human papillomavirus prevalence genotype distribution cervical cancer Public aspects of medicine RA1-1270 Shuang-yang Tang Ya-qi Liao Yu Hu Hai-yan Shen Yan-ping Wan Yi-mou Wu HPV Prevalence and Genotype Distribution Among Women From Hengyang District of Hunan Province, China
description	Most cervical cancers were closely associated with human papillomavirus (HPV) infections. Therefore, understanding the ecological diversity of HPV prevalence and genotype distribution among various populations in different geographical regions was essential for optimizing HPV vaccination and maximizing the vaccination effects. A total of 12,053 patient data from the three-level hospitals in Hengyang city were retrospectively analyzed. In this study, the HPV prevalence was 10.16% overall, and the multiple-type infection rate was 1.83%. The HR-HPV infection rate was 8.52%. The top six HPV genotypes were as follows in descending order: HPV16, HPV58, HPV52, HPV39, HPV51, and HPV53. The HPV prevalence in the group above 60 years old was the most, and their HR-HPV infection rate corresponded to the most too. The infection rates of HPV and HR-HPV among outpatients were both lower than those among the hospitalized-patients, respectively. Among the hospitalized-patients, the infection rates of HPV and HR-HPV among the 50–60 years group were the most in both. The HR-HPV ratio-in-positive among HPV-positive patients with the histopathologic examination was higher than that among those patients without. Among 52 HPV-positive patients with cervical squamous carcinoma, the ratio-in-positive of HPV16 was 61.54%. This study demonstrated that the HPV prevalence varied with age among women from Hengyang district of Hunan province in China and showed that HPV16, HPV58, HPV52, HPV39, HPV51, and HPV53 genotypes were more popularly distributed in this region, which could provide the experimental basis for Chinese public health measures on cervical cancer prevention.
format	article
author	Shuang-yang Tang Ya-qi Liao Yu Hu Hai-yan Shen Yan-ping Wan Yi-mou Wu
author_facet	Shuang-yang Tang Ya-qi Liao Yu Hu Hai-yan Shen Yan-ping Wan Yi-mou Wu
author_sort	Shuang-yang Tang
title	HPV Prevalence and Genotype Distribution Among Women From Hengyang District of Hunan Province, China
title_short	HPV Prevalence and Genotype Distribution Among Women From Hengyang District of Hunan Province, China
title_full	HPV Prevalence and Genotype Distribution Among Women From Hengyang District of Hunan Province, China
title_fullStr	HPV Prevalence and Genotype Distribution Among Women From Hengyang District of Hunan Province, China
title_full_unstemmed	HPV Prevalence and Genotype Distribution Among Women From Hengyang District of Hunan Province, China
title_sort	hpv prevalence and genotype distribution among women from hengyang district of hunan province, china
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/80122c4e27f54c52aabced9e367d21fd
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HPV Prevalence and Genotype Distribution Among Women From Hengyang District of Hunan Province, China

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