Why Are Some <named-content content-type="genus-species">Listeria monocytogenes</named-content> Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?

ABSTRACT Although all isolates of the foodborne pathogen Listeria monocytogenes are considered to be pathogenic, epidemiological evidence indicates that certain serovar 4b lineages are more likely to cause severe invasive (neuromeningeal, maternal-fetal) listeriosis. Recently described as L. monocyt...

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Autores principales:	José A. Vázquez-Boland, Martin Wagner, Mariela Scortti
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Listeria monocytogenes virulence heterogeneity hypervirulent strains prolonged in vivo survival invasive listeriosis in vivo survival Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/80196cb4ce5b4d8ba8ecdb36b9f22eed
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spelling	oai:doaj.org-article:80196cb4ce5b4d8ba8ecdb36b9f22eed2021-11-15T15:55:43ZWhy Are Some <named-content content-type="genus-species">Listeria monocytogenes</named-content> Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?10.1128/mBio.03126-202150-7511https://doaj.org/article/80196cb4ce5b4d8ba8ecdb36b9f22eed2020-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03126-20https://doaj.org/toc/2150-7511ABSTRACT Although all isolates of the foodborne pathogen Listeria monocytogenes are considered to be pathogenic, epidemiological evidence indicates that certain serovar 4b lineages are more likely to cause severe invasive (neuromeningeal, maternal-fetal) listeriosis. Recently described as L. monocytogenes “hypervirulent” clones, no distinctive bacterial trait has been identified so far that could account for the differential pathogenicity of these strains. Here, we discuss some preliminary observations in experimentally infected mice suggesting that serovar 4b hypervirulent strains may have a hitherto unrecognized capacity for prolonged in vivo survival. We propose the hypothesis that protracted survivability in primary infection foci in liver and spleen—the first target organs after intestinal translocation—may cause L. monocytogenes serovar 4b hypervirulent clones to have a higher probability of secondary dissemination to brain and placenta.José A. Vázquez-BolandMartin WagnerMariela ScorttiAmerican Society for MicrobiologyarticleListeria monocytogenesvirulence heterogeneityhypervirulent strainsprolonged in vivo survivalinvasive listeriosisin vivo survivalMicrobiologyQR1-502ENmBio, Vol 11, Iss 6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Listeria monocytogenes virulence heterogeneity hypervirulent strains prolonged in vivo survival invasive listeriosis in vivo survival Microbiology QR1-502
spellingShingle	Listeria monocytogenes virulence heterogeneity hypervirulent strains prolonged in vivo survival invasive listeriosis in vivo survival Microbiology QR1-502 José A. Vázquez-Boland Martin Wagner Mariela Scortti Why Are Some <named-content content-type="genus-species">Listeria monocytogenes</named-content> Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?
description	ABSTRACT Although all isolates of the foodborne pathogen Listeria monocytogenes are considered to be pathogenic, epidemiological evidence indicates that certain serovar 4b lineages are more likely to cause severe invasive (neuromeningeal, maternal-fetal) listeriosis. Recently described as L. monocytogenes “hypervirulent” clones, no distinctive bacterial trait has been identified so far that could account for the differential pathogenicity of these strains. Here, we discuss some preliminary observations in experimentally infected mice suggesting that serovar 4b hypervirulent strains may have a hitherto unrecognized capacity for prolonged in vivo survival. We propose the hypothesis that protracted survivability in primary infection foci in liver and spleen—the first target organs after intestinal translocation—may cause L. monocytogenes serovar 4b hypervirulent clones to have a higher probability of secondary dissemination to brain and placenta.
format	article
author	José A. Vázquez-Boland Martin Wagner Mariela Scortti
author_facet	José A. Vázquez-Boland Martin Wagner Mariela Scortti
author_sort	José A. Vázquez-Boland
title	Why Are Some <named-content content-type="genus-species">Listeria monocytogenes</named-content> Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?
title_short	Why Are Some <named-content content-type="genus-species">Listeria monocytogenes</named-content> Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?
title_full	Why Are Some <named-content content-type="genus-species">Listeria monocytogenes</named-content> Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?
title_fullStr	Why Are Some <named-content content-type="genus-species">Listeria monocytogenes</named-content> Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?
title_full_unstemmed	Why Are Some <named-content content-type="genus-species">Listeria monocytogenes</named-content> Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?
title_sort	why are some <named-content content-type="genus-species">listeria monocytogenes</named-content> genotypes more likely to cause invasive (brain, placental) infection?
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/80196cb4ce5b4d8ba8ecdb36b9f22eed
work_keys_str_mv	AT joseavazquezboland whyaresomenamedcontentcontenttypegenusspecieslisteriamonocytogenesnamedcontentgenotypesmorelikelytocauseinvasivebrainplacentalinfection AT martinwagner whyaresomenamedcontentcontenttypegenusspecieslisteriamonocytogenesnamedcontentgenotypesmorelikelytocauseinvasivebrainplacentalinfection AT marielascortti whyaresomenamedcontentcontenttypegenusspecieslisteriamonocytogenesnamedcontentgenotypesmorelikelytocauseinvasivebrainplacentalinfection
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Why Are Some <named-content content-type="genus-species">Listeria monocytogenes</named-content> Genotypes More Likely To Cause Invasive (Brain, Placental) Infection?

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