Fluid handling and blood flow patterns in neonatal respiratory distress syndrome versus transient tachypnea: a pilot study

Abstract Background Cardiovascular and renal adaptation in neonates with Respiratory Distress Syndrome (RDS) and Transient Tachypnea of the Newborn (TTN) may be different. Methods Neonates ≥32 weeks were diagnosed with RDS or TTN based on clinical, radiologic and lung sonographic criteria. Weight lo...

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Autores principales:	Ismail Rana, Murthy Prashanth, Abou Mehrem Ayman, Liang Zhiying, Stritzke Amelie
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Dopplers Transient tachypnea of the newborn Respiratory distress syndrome Renal transition Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/801c23c7d1104797a2814583f4f64fbd
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spelling	oai:doaj.org-article:801c23c7d1104797a2814583f4f64fbd2021-12-05T12:21:17ZFluid handling and blood flow patterns in neonatal respiratory distress syndrome versus transient tachypnea: a pilot study10.1186/s12887-021-03025-z1471-2431https://doaj.org/article/801c23c7d1104797a2814583f4f64fbd2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-03025-zhttps://doaj.org/toc/1471-2431Abstract Background Cardiovascular and renal adaptation in neonates with Respiratory Distress Syndrome (RDS) and Transient Tachypnea of the Newborn (TTN) may be different. Methods Neonates ≥32 weeks were diagnosed with RDS or TTN based on clinical, radiologic and lung sonographic criteria. Weight loss, feeding, urine output, and sodium levels were recorded for the first 3 days, and serial ultrasounds assessed central and organ Doppler blood flow. A linear mixed model was used to compare the two groups. Results Twenty-one neonates were included, 11 with TTN and 10 with RDS. Those with RDS showed less weight loss (− 2.8 +/− 2.7% versus − 5.6 +/− 3.4%), and less enteral feeds (79.2 vs 116 ml/kg/day) than those with TTN, despite similar fluid prescription. We found no difference in urine output, or serum sodium levels. Doppler parameters for any renal or central parameters were similar. However, Anterior Cerebral Artery maximum velocity was lower (p = 0.03), Superior Mesenteric Artery Resistance Index was higher in RDS, compared to TTN (p = 0.02). Conclusion In cohort of moderately preterm to term neonates, those with RDS retained more fluid and were fed less on day 3 than those with TTN. While there were no renal or central blood flow differences, there were some cerebral and mesenteric perfusion differences which may account for different pathophysiology and management.Ismail RanaMurthy PrashanthAbou Mehrem AymanLiang ZhiyingStritzke AmelieBMCarticleDopplersTransient tachypnea of the newbornRespiratory distress syndromeRenal transitionPediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dopplers Transient tachypnea of the newborn Respiratory distress syndrome Renal transition Pediatrics RJ1-570
spellingShingle	Dopplers Transient tachypnea of the newborn Respiratory distress syndrome Renal transition Pediatrics RJ1-570 Ismail Rana Murthy Prashanth Abou Mehrem Ayman Liang Zhiying Stritzke Amelie Fluid handling and blood flow patterns in neonatal respiratory distress syndrome versus transient tachypnea: a pilot study
description	Abstract Background Cardiovascular and renal adaptation in neonates with Respiratory Distress Syndrome (RDS) and Transient Tachypnea of the Newborn (TTN) may be different. Methods Neonates ≥32 weeks were diagnosed with RDS or TTN based on clinical, radiologic and lung sonographic criteria. Weight loss, feeding, urine output, and sodium levels were recorded for the first 3 days, and serial ultrasounds assessed central and organ Doppler blood flow. A linear mixed model was used to compare the two groups. Results Twenty-one neonates were included, 11 with TTN and 10 with RDS. Those with RDS showed less weight loss (− 2.8 +/− 2.7% versus − 5.6 +/− 3.4%), and less enteral feeds (79.2 vs 116 ml/kg/day) than those with TTN, despite similar fluid prescription. We found no difference in urine output, or serum sodium levels. Doppler parameters for any renal or central parameters were similar. However, Anterior Cerebral Artery maximum velocity was lower (p = 0.03), Superior Mesenteric Artery Resistance Index was higher in RDS, compared to TTN (p = 0.02). Conclusion In cohort of moderately preterm to term neonates, those with RDS retained more fluid and were fed less on day 3 than those with TTN. While there were no renal or central blood flow differences, there were some cerebral and mesenteric perfusion differences which may account for different pathophysiology and management.
format	article
author	Ismail Rana Murthy Prashanth Abou Mehrem Ayman Liang Zhiying Stritzke Amelie
author_facet	Ismail Rana Murthy Prashanth Abou Mehrem Ayman Liang Zhiying Stritzke Amelie
author_sort	Ismail Rana
title	Fluid handling and blood flow patterns in neonatal respiratory distress syndrome versus transient tachypnea: a pilot study
title_short	Fluid handling and blood flow patterns in neonatal respiratory distress syndrome versus transient tachypnea: a pilot study
title_full	Fluid handling and blood flow patterns in neonatal respiratory distress syndrome versus transient tachypnea: a pilot study
title_fullStr	Fluid handling and blood flow patterns in neonatal respiratory distress syndrome versus transient tachypnea: a pilot study
title_full_unstemmed	Fluid handling and blood flow patterns in neonatal respiratory distress syndrome versus transient tachypnea: a pilot study
title_sort	fluid handling and blood flow patterns in neonatal respiratory distress syndrome versus transient tachypnea: a pilot study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/801c23c7d1104797a2814583f4f64fbd
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Fluid handling and blood flow patterns in neonatal respiratory distress syndrome versus transient tachypnea: a pilot study

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