Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy subjects, and show that osteoclast-derived DPP4 may...

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Autores principales:	Megan M. Weivoda, Chee Kian Chew, David G. Monroe, Joshua N. Farr, Elizabeth J. Atkinson, Jennifer R. Geske, Brittany Eckhardt, Brianne Thicke, Ming Ruan, Amanda J. Tweed, Louise K. McCready, Robert A. Rizza, Aleksey Matveyenko, Moustapha Kassem, Thomas Levin Andersen, Adrian Vella, Matthew T. Drake, Bart L. Clarke, Merry Jo Oursler, Sundeep Khosla
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/801d47b97fd94e109d4d6b51b08d8de3
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spelling	oai:doaj.org-article:801d47b97fd94e109d4d6b51b08d8de32021-12-02T15:39:09ZIdentification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism10.1038/s41467-019-14003-62041-1723https://doaj.org/article/801d47b97fd94e109d4d6b51b08d8de32020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14003-6https://doaj.org/toc/2041-1723Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy subjects, and show that osteoclast-derived DPP4 may be a factor coupling bone resorption to energy metabolism.Megan M. WeivodaChee Kian ChewDavid G. MonroeJoshua N. FarrElizabeth J. AtkinsonJennifer R. GeskeBrittany EckhardtBrianne ThickeMing RuanAmanda J. TweedLouise K. McCreadyRobert A. RizzaAleksey MatveyenkoMoustapha KassemThomas Levin AndersenAdrian VellaMatthew T. DrakeBart L. ClarkeMerry Jo OurslerSundeep KhoslaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Megan M. Weivoda Chee Kian Chew David G. Monroe Joshua N. Farr Elizabeth J. Atkinson Jennifer R. Geske Brittany Eckhardt Brianne Thicke Ming Ruan Amanda J. Tweed Louise K. McCready Robert A. Rizza Aleksey Matveyenko Moustapha Kassem Thomas Levin Andersen Adrian Vella Matthew T. Drake Bart L. Clarke Merry Jo Oursler Sundeep Khosla Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism
description	Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy subjects, and show that osteoclast-derived DPP4 may be a factor coupling bone resorption to energy metabolism.
format	article
author	Megan M. Weivoda Chee Kian Chew David G. Monroe Joshua N. Farr Elizabeth J. Atkinson Jennifer R. Geske Brittany Eckhardt Brianne Thicke Ming Ruan Amanda J. Tweed Louise K. McCready Robert A. Rizza Aleksey Matveyenko Moustapha Kassem Thomas Levin Andersen Adrian Vella Matthew T. Drake Bart L. Clarke Merry Jo Oursler Sundeep Khosla
author_facet	Megan M. Weivoda Chee Kian Chew David G. Monroe Joshua N. Farr Elizabeth J. Atkinson Jennifer R. Geske Brittany Eckhardt Brianne Thicke Ming Ruan Amanda J. Tweed Louise K. McCready Robert A. Rizza Aleksey Matveyenko Moustapha Kassem Thomas Levin Andersen Adrian Vella Matthew T. Drake Bart L. Clarke Merry Jo Oursler Sundeep Khosla
author_sort	Megan M. Weivoda
title	Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism
title_short	Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism
title_full	Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism
title_fullStr	Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism
title_full_unstemmed	Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism
title_sort	identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/801d47b97fd94e109d4d6b51b08d8de3
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Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

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