Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis

In order to study the injection and diffusion process of the drug in the subcutaneous tissue of a needle-free jet injectors (NFJIs) in detail and understand the influence of different nozzle geometry on the diffusion process of the drug, in this paper, numerical simulations were performed to study t...

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Autores principales:	Yunfei Wang, Long Yue, Lechuan Hu, Jing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Biotechnology TP248.13-248.65 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/802263068d014e7680a1ec50d4eb6f2f
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spelling	oai:doaj.org-article:802263068d014e7680a1ec50d4eb6f2f2021-11-22T01:09:30ZNeedle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis1754-210310.1155/2021/5199278https://doaj.org/article/802263068d014e7680a1ec50d4eb6f2f2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5199278https://doaj.org/toc/1754-2103In order to study the injection and diffusion process of the drug in the subcutaneous tissue of a needle-free jet injectors (NFJIs) in detail and understand the influence of different nozzle geometry on the diffusion process of the drug, in this paper, numerical simulations were performed to study the diffusion process of the drug in the subcutaneous tissue of NFJIs with cylindrical nozzle. On this basis, the differences of the drug diffusion process with different nozzle geometries were analyzed. The results show that the drug diffused in the shape of ellipsoid in the subcutaneous tissue. The penetration of the drug into the subcutaneous tissue is deeper under the condition of conical nozzle and conical cylindrical nozzle at the same time. However, it takes longer to spread to the interface between skin and subcutaneous tissue in reverse.Yunfei WangLong YueLechuan HuJing WangHindawi LimitedarticleBiotechnologyTP248.13-248.65Biology (General)QH301-705.5ENApplied Bionics and Biomechanics, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Biology (General) QH301-705.5
spellingShingle	Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Yunfei Wang Long Yue Lechuan Hu Jing Wang Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis
description	In order to study the injection and diffusion process of the drug in the subcutaneous tissue of a needle-free jet injectors (NFJIs) in detail and understand the influence of different nozzle geometry on the diffusion process of the drug, in this paper, numerical simulations were performed to study the diffusion process of the drug in the subcutaneous tissue of NFJIs with cylindrical nozzle. On this basis, the differences of the drug diffusion process with different nozzle geometries were analyzed. The results show that the drug diffused in the shape of ellipsoid in the subcutaneous tissue. The penetration of the drug into the subcutaneous tissue is deeper under the condition of conical nozzle and conical cylindrical nozzle at the same time. However, it takes longer to spread to the interface between skin and subcutaneous tissue in reverse.
format	article
author	Yunfei Wang Long Yue Lechuan Hu Jing Wang
author_facet	Yunfei Wang Long Yue Lechuan Hu Jing Wang
author_sort	Yunfei Wang
title	Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis
title_short	Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis
title_full	Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis
title_fullStr	Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis
title_full_unstemmed	Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis
title_sort	needle-free jet injectors’ geometry design and drug diffusion process analysis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/802263068d014e7680a1ec50d4eb6f2f
work_keys_str_mv	AT yunfeiwang needlefreejetinjectorsgeometrydesignanddrugdiffusionprocessanalysis AT longyue needlefreejetinjectorsgeometrydesignanddrugdiffusionprocessanalysis AT lechuanhu needlefreejetinjectorsgeometrydesignanddrugdiffusionprocessanalysis AT jingwang needlefreejetinjectorsgeometrydesignanddrugdiffusionprocessanalysis
_version_	1718418409171976192

Needle-Free Jet Injectors’ Geometry Design and Drug Diffusion Process Analysis

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