Near-infrared spectroscopy of blood plasma with chemometrics towards HIV discrimination during pregnancy

Abstract Prevention of mother-to-child transmission programs have been one of the hallmarks of success in the fight against HIV/AIDS. In Brazil, access to antiretroviral therapy (ART) during pregnancy has increased, leading to a reduction in new infections among children. Currently, lifelong ART is...

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Autores principales:	Daniel L. D. Freitas, Ana F. S. Peres, Lidiane G. Silva, João V. M. Mariz, Marcos G. Santos, Rayanne S. P. Morais, Camilo L. M. Morais, Francis L. Martin, Daniel A. V. Pascoal, Juliana D. de A. S. Camargo, Janaina C. O. Crispim, Kassio M. G. Lima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/802702dc14a34eddb8684fc9b046f10a
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spelling	oai:doaj.org-article:802702dc14a34eddb8684fc9b046f10a2021-11-21T12:25:23ZNear-infrared spectroscopy of blood plasma with chemometrics towards HIV discrimination during pregnancy10.1038/s41598-021-02105-52045-2322https://doaj.org/article/802702dc14a34eddb8684fc9b046f10a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02105-5https://doaj.org/toc/2045-2322Abstract Prevention of mother-to-child transmission programs have been one of the hallmarks of success in the fight against HIV/AIDS. In Brazil, access to antiretroviral therapy (ART) during pregnancy has increased, leading to a reduction in new infections among children. Currently, lifelong ART is available to all pregnant, however yet challenges remain in eliminating mother-to-child transmission. In this paper, we focus on the role of near-infrared (NIR) spectroscopy to analyse blood plasma samples of pregnant women with HIV infection to differentiate pregnant women without HIV infection. Seventy-seven samples (39 HIV-infected patient and 38 healthy control samples) were analysed. Multivariate classification of resultant NIR spectra facilitated diagnostic segregation of both sample categories in a fast and non-destructive fashion, generating good accuracy, sensitivity and specificity. This method is simple and low-cost, and can be easily adapted to point-of-care screening, which can be essential to monitor pregnancy risks in remote locations or in the developing world. Therefore, it opens a new perspective to investigate vertical transmission (VT). The approach described here, can be useful for the identification and exploration of VT under various pathophysiological conditions of maternal HIV. These findings demonstrate, for the first time, the potential of NIR spectroscopy combined with multivariate analysis as a screening tool for fast and low-cost HIV detection.Daniel L. D. FreitasAna F. S. PeresLidiane G. SilvaJoão V. M. MarizMarcos G. SantosRayanne S. P. MoraisCamilo L. M. MoraisFrancis L. MartinDaniel A. V. PascoalJuliana D. de A. S. CamargoJanaina C. O. CrispimKassio M. G. LimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel L. D. Freitas Ana F. S. Peres Lidiane G. Silva João V. M. Mariz Marcos G. Santos Rayanne S. P. Morais Camilo L. M. Morais Francis L. Martin Daniel A. V. Pascoal Juliana D. de A. S. Camargo Janaina C. O. Crispim Kassio M. G. Lima Near-infrared spectroscopy of blood plasma with chemometrics towards HIV discrimination during pregnancy
description	Abstract Prevention of mother-to-child transmission programs have been one of the hallmarks of success in the fight against HIV/AIDS. In Brazil, access to antiretroviral therapy (ART) during pregnancy has increased, leading to a reduction in new infections among children. Currently, lifelong ART is available to all pregnant, however yet challenges remain in eliminating mother-to-child transmission. In this paper, we focus on the role of near-infrared (NIR) spectroscopy to analyse blood plasma samples of pregnant women with HIV infection to differentiate pregnant women without HIV infection. Seventy-seven samples (39 HIV-infected patient and 38 healthy control samples) were analysed. Multivariate classification of resultant NIR spectra facilitated diagnostic segregation of both sample categories in a fast and non-destructive fashion, generating good accuracy, sensitivity and specificity. This method is simple and low-cost, and can be easily adapted to point-of-care screening, which can be essential to monitor pregnancy risks in remote locations or in the developing world. Therefore, it opens a new perspective to investigate vertical transmission (VT). The approach described here, can be useful for the identification and exploration of VT under various pathophysiological conditions of maternal HIV. These findings demonstrate, for the first time, the potential of NIR spectroscopy combined with multivariate analysis as a screening tool for fast and low-cost HIV detection.
format	article
author	Daniel L. D. Freitas Ana F. S. Peres Lidiane G. Silva João V. M. Mariz Marcos G. Santos Rayanne S. P. Morais Camilo L. M. Morais Francis L. Martin Daniel A. V. Pascoal Juliana D. de A. S. Camargo Janaina C. O. Crispim Kassio M. G. Lima
author_facet	Daniel L. D. Freitas Ana F. S. Peres Lidiane G. Silva João V. M. Mariz Marcos G. Santos Rayanne S. P. Morais Camilo L. M. Morais Francis L. Martin Daniel A. V. Pascoal Juliana D. de A. S. Camargo Janaina C. O. Crispim Kassio M. G. Lima
author_sort	Daniel L. D. Freitas
title	Near-infrared spectroscopy of blood plasma with chemometrics towards HIV discrimination during pregnancy
title_short	Near-infrared spectroscopy of blood plasma with chemometrics towards HIV discrimination during pregnancy
title_full	Near-infrared spectroscopy of blood plasma with chemometrics towards HIV discrimination during pregnancy
title_fullStr	Near-infrared spectroscopy of blood plasma with chemometrics towards HIV discrimination during pregnancy
title_full_unstemmed	Near-infrared spectroscopy of blood plasma with chemometrics towards HIV discrimination during pregnancy
title_sort	near-infrared spectroscopy of blood plasma with chemometrics towards hiv discrimination during pregnancy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/802702dc14a34eddb8684fc9b046f10a
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Near-infrared spectroscopy of blood plasma with chemometrics towards HIV discrimination during pregnancy

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