Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

How NALP7 inflammasome formation is regulated is unclear. Here the authors show that STAMBP prevents lysosomal degradation of NALP7 and present BC-1471 as a potential therapeutic STAMBP inhibitor, showing it can reduce TLR-induced IL-1β production.

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Autores principales:	Joseph S. Bednash, Nathaniel Weathington, James Londino, Mauricio Rojas, Dexter L. Gulick, Robert Fort, SeungHye Han, Alison C. McKelvey, Bill B. Chen, Rama K. Mallampalli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8027cc56a6434dbba494ef06f489040c
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spelling	oai:doaj.org-article:8027cc56a6434dbba494ef06f489040c2021-12-02T14:41:08ZTargeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity10.1038/ncomms152032041-1723https://doaj.org/article/8027cc56a6434dbba494ef06f489040c2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15203https://doaj.org/toc/2041-1723How NALP7 inflammasome formation is regulated is unclear. Here the authors show that STAMBP prevents lysosomal degradation of NALP7 and present BC-1471 as a potential therapeutic STAMBP inhibitor, showing it can reduce TLR-induced IL-1β production.Joseph S. BednashNathaniel WeathingtonJames LondinoMauricio RojasDexter L. GulickRobert FortSeungHye HanAlison C. McKelveyBill B. ChenRama K. MallampalliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph S. Bednash Nathaniel Weathington James Londino Mauricio Rojas Dexter L. Gulick Robert Fort SeungHye Han Alison C. McKelvey Bill B. Chen Rama K. Mallampalli Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity
description	How NALP7 inflammasome formation is regulated is unclear. Here the authors show that STAMBP prevents lysosomal degradation of NALP7 and present BC-1471 as a potential therapeutic STAMBP inhibitor, showing it can reduce TLR-induced IL-1β production.
format	article
author	Joseph S. Bednash Nathaniel Weathington James Londino Mauricio Rojas Dexter L. Gulick Robert Fort SeungHye Han Alison C. McKelvey Bill B. Chen Rama K. Mallampalli
author_facet	Joseph S. Bednash Nathaniel Weathington James Londino Mauricio Rojas Dexter L. Gulick Robert Fort SeungHye Han Alison C. McKelvey Bill B. Chen Rama K. Mallampalli
author_sort	Joseph S. Bednash
title	Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity
title_short	Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity
title_full	Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity
title_fullStr	Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity
title_full_unstemmed	Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity
title_sort	targeting the deubiquitinase stambp inhibits nalp7 inflammasome activity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8027cc56a6434dbba494ef06f489040c
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Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

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