Computational quantification of global effects induced by mutations and drugs in signaling networks of colorectal cancer cells

Computational quantification of global effects induced by mutations and drugs in signaling networks of colorectal cancer cells

Abstract Colorectal cancer (CRC) is one of the most deadly and commonly diagnosed tumors worldwide. Several genes are involved in its development and progression. The most frequent mutations concern APC, KRAS, SMAD4, and TP53 genes, suggesting that CRC relies on the concomitant alteration of the rel...

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Autores principales: Sara Sommariva, Giacomo Caviglia, Silvia Ravera, Francesco Frassoni, Federico Benvenuto, Lorenzo Tortolina, Nicoletta Castagnino, Silvio Parodi, Michele Piana
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/802c1bfca65b4b31bfbc6dfdc6509270
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