Low HDL and high triglycerides predict COVID-19 severity

Abstract Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cros...

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Autores principales:	Lluís Masana, Eudald Correig, Daiana Ibarretxe, Eva Anoro, Juan Antonio Arroyo, Carlos Jericó, Carolina Guerrero, Marcel·la Miret, Silvia Näf, Anna Pardo, Verónica Perea, Rosa Pérez-Bernalte, Núria Plana, Rafael Ramírez-Montesinos, Meritxell Royuela, Cristina Soler, Maria Urquizu-Padilla, Alberto Zamora, Juan Pedro-Botet, the STACOV-XULA research group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8030e0fcdba8492eaace76abc5a9b5b5
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spelling	oai:doaj.org-article:8030e0fcdba8492eaace76abc5a9b5b52021-12-02T14:25:09ZLow HDL and high triglycerides predict COVID-19 severity10.1038/s41598-021-86747-52045-2322https://doaj.org/article/8030e0fcdba8492eaace76abc5a9b5b52021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86747-5https://doaj.org/toc/2045-2322Abstract Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.Lluís MasanaEudald CorreigDaiana IbarretxeEva AnoroJuan Antonio ArroyoCarlos JericóCarolina GuerreroMarcel·la MiretSilvia NäfAnna PardoVerónica PereaRosa Pérez-BernalteNúria PlanaRafael Ramírez-MontesinosMeritxell RoyuelaCristina SolerMaria Urquizu-PadillaAlberto ZamoraJuan Pedro-Botetthe STACOV-XULA research groupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lluís Masana Eudald Correig Daiana Ibarretxe Eva Anoro Juan Antonio Arroyo Carlos Jericó Carolina Guerrero Marcel·la Miret Silvia Näf Anna Pardo Verónica Perea Rosa Pérez-Bernalte Núria Plana Rafael Ramírez-Montesinos Meritxell Royuela Cristina Soler Maria Urquizu-Padilla Alberto Zamora Juan Pedro-Botet the STACOV-XULA research group Low HDL and high triglycerides predict COVID-19 severity
description	Abstract Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.
format	article
author	Lluís Masana Eudald Correig Daiana Ibarretxe Eva Anoro Juan Antonio Arroyo Carlos Jericó Carolina Guerrero Marcel·la Miret Silvia Näf Anna Pardo Verónica Perea Rosa Pérez-Bernalte Núria Plana Rafael Ramírez-Montesinos Meritxell Royuela Cristina Soler Maria Urquizu-Padilla Alberto Zamora Juan Pedro-Botet the STACOV-XULA research group
author_facet	Lluís Masana Eudald Correig Daiana Ibarretxe Eva Anoro Juan Antonio Arroyo Carlos Jericó Carolina Guerrero Marcel·la Miret Silvia Näf Anna Pardo Verónica Perea Rosa Pérez-Bernalte Núria Plana Rafael Ramírez-Montesinos Meritxell Royuela Cristina Soler Maria Urquizu-Padilla Alberto Zamora Juan Pedro-Botet the STACOV-XULA research group
author_sort	Lluís Masana
title	Low HDL and high triglycerides predict COVID-19 severity
title_short	Low HDL and high triglycerides predict COVID-19 severity
title_full	Low HDL and high triglycerides predict COVID-19 severity
title_fullStr	Low HDL and high triglycerides predict COVID-19 severity
title_full_unstemmed	Low HDL and high triglycerides predict COVID-19 severity
title_sort	low hdl and high triglycerides predict covid-19 severity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8030e0fcdba8492eaace76abc5a9b5b5
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Low HDL and high triglycerides predict COVID-19 severity

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