Treatable Traits in Chronic Respiratory Disease: A Comprehensive Review

Chronic respiratory diseases are major contributors to the global burden of disease. While understanding of these diseases has improved, treatment guidelines have continued to rely on severity and exacerbation-based approaches. A new personalised approach, termed the “treatable traits” approach, has...

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Autores principales:	Yong Qin Lee, Asvin Selvakumar, Kay Choong See
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	treatable trait chronic respiratory disease multidisciplinary personalised medicine Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8031a4b7d5a84214a22a758db2374139
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spelling	oai:doaj.org-article:8031a4b7d5a84214a22a758db23741392021-11-25T17:13:25ZTreatable Traits in Chronic Respiratory Disease: A Comprehensive Review10.3390/cells101132632073-4409https://doaj.org/article/8031a4b7d5a84214a22a758db23741392021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3263https://doaj.org/toc/2073-4409Chronic respiratory diseases are major contributors to the global burden of disease. While understanding of these diseases has improved, treatment guidelines have continued to rely on severity and exacerbation-based approaches. A new personalised approach, termed the “treatable traits” approach, has been suggested to address the limitations of the existing treatment strategies. We aim to systematically review the current evidence regarding treatable traits in chronic respiratory diseases and to identify gaps in the current literature. We searched the PubMed and Embase databases and included studies on treatable traits and chronic respiratory diseases. We then extracted information on prevalence, prognostic implications, treatment options and benefits from these studies. A total of 58 papers was included for review. The traits identified were grouped into five broad themes: physiological, biochemical, psychosocial, microbiological, and comorbidity traits. Studies have shown advantages of the treatable traits paradigm in the clinical setting. However, few randomised controlled trials have been conducted. Findings from our review suggest that multidisciplinary management with therapies targeted at treatable traits has the potential to be efficacious when added to the best practices currently implemented. This paradigm has the potential to improve the holistic care of chronic respiratory diseases.Yong Qin LeeAsvin SelvakumarKay Choong SeeMDPI AGarticletreatable traitchronic respiratory diseasemultidisciplinarypersonalised medicineBiology (General)QH301-705.5ENCells, Vol 10, Iss 3263, p 3263 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	treatable trait chronic respiratory disease multidisciplinary personalised medicine Biology (General) QH301-705.5
spellingShingle	treatable trait chronic respiratory disease multidisciplinary personalised medicine Biology (General) QH301-705.5 Yong Qin Lee Asvin Selvakumar Kay Choong See Treatable Traits in Chronic Respiratory Disease: A Comprehensive Review
description	Chronic respiratory diseases are major contributors to the global burden of disease. While understanding of these diseases has improved, treatment guidelines have continued to rely on severity and exacerbation-based approaches. A new personalised approach, termed the “treatable traits” approach, has been suggested to address the limitations of the existing treatment strategies. We aim to systematically review the current evidence regarding treatable traits in chronic respiratory diseases and to identify gaps in the current literature. We searched the PubMed and Embase databases and included studies on treatable traits and chronic respiratory diseases. We then extracted information on prevalence, prognostic implications, treatment options and benefits from these studies. A total of 58 papers was included for review. The traits identified were grouped into five broad themes: physiological, biochemical, psychosocial, microbiological, and comorbidity traits. Studies have shown advantages of the treatable traits paradigm in the clinical setting. However, few randomised controlled trials have been conducted. Findings from our review suggest that multidisciplinary management with therapies targeted at treatable traits has the potential to be efficacious when added to the best practices currently implemented. This paradigm has the potential to improve the holistic care of chronic respiratory diseases.
format	article
author	Yong Qin Lee Asvin Selvakumar Kay Choong See
author_facet	Yong Qin Lee Asvin Selvakumar Kay Choong See
author_sort	Yong Qin Lee
title	Treatable Traits in Chronic Respiratory Disease: A Comprehensive Review
title_short	Treatable Traits in Chronic Respiratory Disease: A Comprehensive Review
title_full	Treatable Traits in Chronic Respiratory Disease: A Comprehensive Review
title_fullStr	Treatable Traits in Chronic Respiratory Disease: A Comprehensive Review
title_full_unstemmed	Treatable Traits in Chronic Respiratory Disease: A Comprehensive Review
title_sort	treatable traits in chronic respiratory disease: a comprehensive review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8031a4b7d5a84214a22a758db2374139
work_keys_str_mv	AT yongqinlee treatabletraitsinchronicrespiratorydiseaseacomprehensivereview AT asvinselvakumar treatabletraitsinchronicrespiratorydiseaseacomprehensivereview AT kaychoongsee treatabletraitsinchronicrespiratorydiseaseacomprehensivereview
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Treatable Traits in Chronic Respiratory Disease: A Comprehensive Review

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